A5032067791- Cannabis and Cannabinoid Research
- Hypothalamic control of reproductive hormones
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Effects and risks of endocrine disrupting chemicals
- Pancreatic function and diabetes
- Plant Reproductive Biology
- Reproductive Biology and Fertility
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Heat shock proteins research
- Reproductive biology and impacts on aquatic species
- Ovarian function and disorders
- Prenatal Substance Exposure Effects
- Dietary Effects on Health
- Microplastics and Plastic Pollution
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Diet and metabolism studies
- Polyamine Metabolism and Applications
- Toxic Organic Pollutants Impact
- Endoplasmic Reticulum Stress and Disease
- Sleep and Wakefulness Research
Parthenope University of Naples
2016-2025
University of Campania "Luigi Vanvitelli"
2005-2009
University of Naples Federico II
1999-2005
Institute of Genetics and Biophysics
1999
Marijuana smokers and animals treated with Δ9-tetrahydrocannabinol, the principal component of marijuana, show alterations sperm morphology suggesting a role for cannabinoids in differentiation and/or maturation. Because cannabinoid receptor 1 (CNR1) activation appears to play pivotal spermiogenesis, developmental stage where DNA is remodeled, we hypothesized that CNR1 receptors might also influence chromatin quality sperm. We used Cnr1 null mutant (Cnr1−/−) mice study possible...
Abstract Spermatogenesis depends on endocrine, autocrine and paracrine communications along the hypothalamus-pituitary-gonad axis. Bisphenol A (BPA), an estrogen-mimic endocrine disrupting chemical, is environmental contaminant used to manufacture polycarbonate plastics epoxy resins with toxic effects for male reproduction. Here we investigated whether chronic exposure low BPA doses affects spermatogenesis through modulation of SIRT1, a NAD + -dependent deacetylase involved in progression...
Over the last few decades, emerging evidence suggests that non-coding RNAs (ncRNAs) including long-non-coding RNA (lncRNA), microRNA (miRNA) and circular-RNA (circRNA) contribute to molecular events underlying progressive neuronal degeneration, a plethora of ncRNAs have been identified significantly misregulated in many neurodegenerative diseases, Parkinson’s disease synucleinopathy. Although direct link between neuropathology causative candidates has not clearly established cases,...
N-arachidonoylethanolamide (anandamide [AEA]) is the main endocannabinoid described to date in testis. It exerts its effects through activation of G-protein coupled cannabinoid receptors (CNR). However, activity AEA controlling male reproduction still poorly known. Here we provide direct evidence on presence "endocannabinoid system," constituted by type-1 receptor (CNR1) and fatty acid amide hydrolase (FAAH), frog Rana esculenta testis demonstrating expression tubular compartment. In fact,...
The goal of our study was to molecularly dissect mesothelioma tumour pathways by mean microarray technologies in order identify new biomarkers that could be used as early diagnostic markers and possibly specific molecular therapeutic targets.
During transit through the epididymis, spermatozoa are normally kept immotile and do not attain ability to become motile until they reach caudal epididymis. This study was undertaken determine whether endocannabinoids play a role in epididymis particular suppressing of motile. We show that levels endocannabinoid 2-arachidonoylglycerol (2-AG) high mouse isolated from caput (head) where these cells move (or possess sluggish irregular motility) decrease dramatically cauda (tail). The subsequent...
The control of male fertility requires accurate endocrine, paracrine and autocrine communications along the hypothalamus-pituitary-gonad (HPG) axis. In this respect, possible interplay between upcoming/classical modulators reproductive functions deserves attention in that may be a successful tool for future exploitation new potential therapeutic targets treatment disorders.In review we will discuss upcoming data concerning role kisspeptins, products Kiss1 gene, estrogens - classically...