A5001003414- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Neuroscience and Neuropharmacology Research
- Cardiovascular and exercise physiology
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
- Photochromic and Fluorescence Chemistry
- Neurotransmitter Receptor Influence on Behavior
- Antioxidant Activity and Oxidative Stress
- Photoreceptor and optogenetics research
- Endoplasmic Reticulum Stress and Disease
- Cardiac pacing and defibrillation studies
- Sphingolipid Metabolism and Signaling
- Pharmacology and Obesity Treatment
- Protein Hydrolysis and Bioactive Peptides
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Phytochemicals and Antioxidant Activities
- Kruppel-like factors research
- Lipid Membrane Structure and Behavior
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
University of Salerno
2018-2025
Istituto Neurologico Mediterraneo
2012-2023
University of Siena
2021
Chronic kidney disease (CKD) is a global health issue with rising prevalence, affecting 697.5 million people worldwide. It imposes substantial burden, contributing to 35.8 disability-adjusted life years (DALYs) and 1.2 deaths in 2017. The mortality rate for CKD has increased by 41.5% between 1990 2017, positioning it as significant cause of mortality. associated diverse complications, impacting cardiovascular, neurological, nutritional, endocrine aspects. One prominent complication...
In recent decades, as a result of rising mortality rates due to cardiovascular diseases (CVDs), there has been growing urgency find alternative approaches conventional pharmaceutical treatment prevent the onset chronic diseases.
Heart Failure (HF) is a syndrome, which implies the existence of different phenotypes. The new categorization includes patients with preserved ejection fraction (HFpEF), mid-range EF (HFmrEF), and reduced (HFrEF) but molecular mechanisms involved in these HF phenotypes have not yet been exhaustively investigated. Sirt1 plays crucial role biological processes strongly related to HF. This study aimed evaluate whether activity was correlated other parameters HFpEF, HFmrEF, HFrEF. Seventy...
Sortilin has been positively correlated with vascular disorders in humans. No study yet evaluated the possible direct effect of sortilin on function. We used pharmacological and genetic approaches coupled murine human samples to unravel mechanisms recruited by system. induced endothelial dysfunction mesenteric arteries through NADPH oxidase 2 (NOX2) isoform activation, that was prevented knockdown acid sphingomyelinase (ASMase) or sphingosine kinase 1. In vivo, recombinant administration...
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator raseglurant. Violet light illumination induces photochemical reaction prompting active-drug’s release, which effectively controls mGlu5 activity both ectopic expressing systems and striatal primary...
PARK20, an early onset autosomal recessive parkinsonism is due to mutations in the phosphatidylinositol-phosphatase Synaptojanin 1 (Synj1). We have recently shown that endosomal compartments are profoundly altered PARK20 fibroblasts as well trafficking. Here, we report also display a drastic alteration of architecture and function secretory compartments. Our results show exit machinery from Endoplasmic Reticulum (ER) ER-to-Golgi trafficking markedly compromised patient cells. As consequence,...
Abstract Recent findings indicate that fingolimod, the first oral drug approved for treatment of multiple sclerosis ( MS ), acts as a direct inhibitor histone deacetylases HDAC s) and enhances production brain‐derived neurotrophic factor BDNF ) in CNS . Both mechanisms are relevant to pathophysiology major depression. We examined antidepressant activity fingolimod mice subjected chronic unpredictable stress CUS model reactive depression endowed with face pharmacological validity. Chronic (3...
ß-amyloid (Aß1-42) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß1-42self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, are considered culprit Alzheimer's disease (AD). However, Aß1-42 mainly monomeric at physiological concentrations, precise role in function largely unknown. We report that monomer activates insulin-like growth factor receptors enhances glucose uptake...
The angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan (Sac/Val) demonstrated to be superior enalapril in reducing hospitalizations, cardiovascular and all-cause mortality patients with ambulatory heart failure reduced ejection fraction (HFrEF), particular when it is maximally up-titrated. Unfortunately, the target dose achieved less than 50% of HFrEF patients, thus undermining beneficial effects on outcomes. In this study, we aimed evaluate role Sac/Val its titration...
Omega-3 fatty acids have been shown to exert several beneficial effects in the prevention of cardiovascular and cerebrovascular diseases. The objective present study was analyze a novel high-load omega-3 lysine complex, AvailOm®, its related constituents mixture AvailOm® with specific vasoactive anthocyanins on vascular function mice resistance artery. Pressure myograph used perform reactivity studies. Nitric oxide oxidative stress were assessed by difluorofluorescein diacetate...
Phosphatidylcholine (PC) vesicles loaded with Triiodothyronine (T3) were fabricated using different manufacturing methods: thin layer hydration plus sonication (TF-UF), supercritical liposome formation (SC), and microfluidic technology (MF). Vesicles obtained by MF had the lowest mean diameter (88.61 ± 44.48 nm) a Zeta Potential of -20.1 5.90 mV loading 10 mg/g (encapsulation efficiency: 57%). In contrast, SC showed extremely low encapsulation efficiency (<10%) probably due to T3 solubility...
Abstract Beyond well-assessed risk factors, cardiovascular events could be also associated with the presence of epigenetic and genetic alterations, such as methylenetetrahydrofolate-reductase ( MTHFR ) C677T polymorphism. This gene variant is related to increased circulating levels homocysteine (Hcy) risk. However, heterozygous carriers have an augmented accidents independently from normal Hcy levels, suggesting additional deregulated processes in carriers. Here, we hypothesize that...
Abstract Aims We report the results of a real‐world study based on heart failure (HF) patients' continuous remote monitoring strategy using CardioMEMS system to assess impact this device healthcare outcomes, costs, and management quality life. Methods enrolled seven patients (69.00 ± 4.88 years; 71.43% men) with HF, implanted CardioMEMS, daily monitored optimize both tailored adjustments home therapy and/or hospital infusions levosimendan. recorded clinical, pharmacological, biochemical,...
Catecholamine nuclei within the brainstem reticular formation (RF) play a pivotal role in variety of brain functions.However, systematic characterization these very same experimental conditions is missing so far.Tyrosine hydroxylase (TH) immunepositive cells correspond to dopamine (DA)-, norepinephrine (NE)-, and epinephrine (E)-containing cells.Here, we report count TH-positive neurons RF mouse by using stereological morphometry.All were analyzed for anatomical localization, rostro-caudal...
Purpose . Exercise training induces beneficial effects also by increasing levels of Sirtuin 1 (Sirt1) and β -hydroxybutyrate ( OHB). Up to date, no studies investigated the role exercise training-based cardiac rehabilitation (ET-CR) programs on OHB levels. Therefore, present study is aimed at investigating whether a supervised 4-week ET-CR program was able induce changes in Sirt1 activity evaluate possible relationship between such parameters, Heart Failure with preserved Ejection Fraction...