A5027977580- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Long-Term Effects of COVID-19
- Heart Failure Treatment and Management
- Pharmacological Effects and Toxicity Studies
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Cardiac pacing and defibrillation studies
- Trace Elements in Health
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Risk Factors
- Vitamin C and Antioxidants Research
- Gout, Hyperuricemia, Uric Acid
- Nutrition, Genetics, and Disease
- Lipid metabolism and disorders
- COVID-19 and Mental Health
- Medication Adherence and Compliance
- Alcohol Consumption and Health Effects
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2013-2024
University of Salerno
2015-2022
Federico II University Hospital
2017-2018
Chronic kidney disease (CKD) is a global health issue with rising prevalence, affecting 697.5 million people worldwide. It imposes substantial burden, contributing to 35.8 disability-adjusted life years (DALYs) and 1.2 deaths in 2017. The mortality rate for CKD has increased by 41.5% between 1990 2017, positioning it as significant cause of mortality. associated diverse complications, impacting cardiovascular, neurological, nutritional, endocrine aspects. One prominent complication...
Abstract Background Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes often accompanied by cardiovascular comorbidities such hypertension, elevating the risk of pre-frailty frailty. Albuminuria hallmark organ damage in hypertension amplifying pre-frailty, frailty, cognitive decline older adults. We explored association between albuminuria impairment...
Sortilin has been positively correlated with vascular disorders in humans. No study yet evaluated the possible direct effect of sortilin on function. We used pharmacological and genetic approaches coupled murine human samples to unravel mechanisms recruited by system. induced endothelial dysfunction mesenteric arteries through NADPH oxidase 2 (NOX2) isoform activation, that was prevented knockdown acid sphingomyelinase (ASMase) or sphingosine kinase 1. In vivo, recombinant administration...
Abstract Aims We report the results of a real‐world study based on heart failure (HF) patients' continuous remote monitoring strategy using CardioMEMS system to assess impact this device healthcare outcomes, costs, and management quality life. Methods enrolled seven patients (69.00 ± 4.88 years; 71.43% men) with HF, implanted CardioMEMS, daily monitored optimize both tailored adjustments home therapy and/or hospital infusions levosimendan. recorded clinical, pharmacological, biochemical,...
Background High blood pressure (BP) has long been recognized as a major health threat and, particularly, risk factor for stroke, cardiovascular disease, and end-organ damage. However, the identification of novel, alternative, integrative approach control BP protection is still needed. Methods Results Sixty-nine uncontrolled hypertension patients, aged 40 to 68 years, on antihypertensive medication were enrolled in 2 double-blind studies. Forty-five randomized placebo or new nutraceutical...
Serum uric acid (sUA) has been associated with cardiovascular risk. Although the recent mechanistic hypothesis poses basis for association between sUA and left ventricular mass index (LVMi), issue remains poorly investigated in a clinical setup. Through retrospective analysis of database departmental Hypertension Clinic University Hospital Salerno Medical School, we identified 177 essential hypertensives (age 60.3 ± 13.3 years; 85 men), free from acid-modulating medications severe chronic...
Sacubitril/valsartan (Sac/Val) reduces mortality in patients with heart failure reduced ejection fraction (HFrEF) compared to enalapril. However, its effects on functional capacity remain uncertain; consequently, we sought compare Sac/Val vs. standard medical therapy, terms of prognostically significant CPET parameters, HFrEF during a long follow-up period. We conducted single-center, observational study an HF clinic; specifically, retrospectively identified that 12 switched and 13 managed...
Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i) represent a deep revolution of the therapeutic approach to heart failure (HF), preventing its insurgence but also improving management disease and slowing natural progression. To date, few studies have explored effectiveness SGLT2i and, in particular, Dapagliflozin real-world population. Therefore, this observational prospective study, we evaluated Dapagliflozin's HF population categorized different hemodynamic profiles. From January 2022...
Chronic kidney disease (CKD) and cardiovascular (CVD) are highly prevalent conditions, each significantly contributing to the global burden of morbidity mortality. CVD CKD share a great number common risk factor, such as hypertension, diabetes, obesity, smoking among others. Their relationship extends beyond these factors, encompassing intricate interplay between two systems. Within this complex network pathophysiological processes, vitamin D has emerged potential linchpin, exerting...
Chronic kidney disease (CKD) and cardiovascular (CVD) are highly prevalent conditions, each significantly contributing to the global burden of morbidity mortality. CVD CKD share a great number common risk factors, such as hypertension, diabetes, obesity, smoking, among others. Their relationship extends beyond these encompassing intricate interplay between two systems. Within this complex network pathophysiological processes, vitamin D has emerged potential linchpin, exerting influence over...
Severe obesity is closely associated with an increased risk of comorbidities and alterations in cardiac structure function. The primary objective this study was to investigate cardiovascular (CV) factors ventricular remodeling individuals from obese population eligible for bariatric surgery. secondary evaluate changes anthropometric, clinical laboratory, echocardiographic measurements 12 weeks after surgery compared baseline values. This retrospective observational cohort involved patients a...
Background: Cardiovascular diseases (CVD) are the leading causes of death worldwide. Keywords: Nutraceuticals, resveratrol, exercise training, physical activity, cardiovascular risk, non-pharmacological.
Abstract Background Heart failure (HF) alternates phases of stability and exacerbation, with a progressive decline in the patient's functional capacity quality life; need to anticipate improve effectiveness management HF exacerbation has led development several remote monitoring tools. We report our experience CardioMEMS system (implantable device monitor changes pulmonary artery diastolic pressure (PAPd) as early indicator onset worsening HF) order optimize pharmaceutical treatments...