A5049410743- Comparative Animal Anatomy Studies
- Tissue Engineering and Regenerative Medicine
- Reproductive Physiology in Livestock
- Animal Genetics and Reproduction
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Electrospun Nanofibers in Biomedical Applications
- Fish biology, ecology, and behavior
- Muscle Physiology and Disorders
- Meat and Animal Product Quality
- Evolution and Paleontology Studies
- Sperm and Testicular Function
- Animal Nutrition and Physiology
- Birth, Development, and Health
- Veterinary Equine Medical Research
- Congenital Anomalies and Fetal Surgery
- Genetic and phenotypic traits in livestock
- Renal and related cancers
- Ichthyology and Marine Biology
- Reproductive System and Pregnancy
- Aquaculture Nutrition and Growth
- Congenital heart defects research
- Rabbits: Nutrition, Reproduction, Health
- Marine animal studies overview
Universidade de São Paulo
2016-2025
Universidade Brasil
2007-2025
Universidade de Marília
2023-2025
Universidade Cidade de São Paulo
1995-2023
Universidad San Pablo
2019-2023
Hospital Universitário da Universidade de São Paulo
2003-2022
Ospedale Policlinico San Martino
2001-2022
University of Genoa
1993-2022
Fundação Armando Alvares Penteado
2003-2022
Colciencias
2021
Abstract Background The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at future treatment of human Duchenne (DMD). We have obtained a rare litter six GRMD (3 males and 3 females) born from an affected male carrier female which were submitted to trial with adult stem cells investigate their capacity engraft into muscles by local as compared systemic injection without any immunosuppression. Methods Human Immature Dental...
Isolation of mesenchymal stem cells (MSCs) in equines, has been reported for different tissues including bone marrow, adipose, umbilical cord, peripheral blood, and yolk sac. In regard to the MSCs derived from synovial fluid (SF) or membrane (SM), there is data available humans, dogs, pigs, goats horses. Especially these have being considered promising candidates articular regeneration. Herein, we established characterized obtained equine SF SM. Samples were during arthroscopy cultured using...
Induced pluripotent stem cells (iPSCs) can be created by forcing expression of certain genes in fibroblasts or other somatic cell types, reversing them to a state similar that embryonic (ESC). Here, we used human immature dental pulp (hIDPSCs) as an alternative source for creating iPSC. hIDPSCs easily isolated from accessible tissue young and adult patients. possess fibroblast-like morphology, retaining characteristics multipotent cells. Reprogramming was fast, producing primary hIDPSC-iPSC...
Background Imatinib mesylate is the first line treatment for chronic myeloid leukemia. In patients with advanced phase of disease, advent imatinib significantly increased survival. However, few long-term data, based on large, prospective and controlled trials are available outcome these patients.Design Methods We conducted a II trial 600 mg daily in leukemia blast crisis. The return to was defined as
During fetal development, mesenchymal progenitor (MP) cells are co-localized in major hematopoietic territories, such as yolk sac (YS), bone marrow (BM), liver (LV), and others. Studies using mouse human MP isolated from fetus have shown that these very similar but not identical to adult stem (MSC). Their differentiation potential is usually restricted production of highly committed osteogenic chondrogenic precursors. Such properties can be useful for tissue regeneration, when a great number...
Maternal immunity is the main early defense against infectious agents in newborns. Immunoglobulin G (IgG) indispensable for immune agents. IgG transported through either colostrum or placenta. Immunoglobulins are antibodies, and five different classes of these antibodies IgG, IgA, IgM, IgD IgE. Through their biological function binding antigens, facilitate removal antigens from body. The placenta a temporary maternal-fetal organ, whose principal to allow controlled exchange metabolites...
Placentas of guinea pig-related rodents are appropriate animal models for human placentation because their striking similarities to those humans. To optimize the pool potential in this context, it is essential identify occurrence characters close relatives.In study we first analyzed chorioallantoic prea, Galea spixii, as one pig's closest relatives. Material was collected from a breeding group at University Mossoró, Brazil, including 18 individuals covering an ontogenetic sequence initial...
In spite of numerous, substantial advances in equine reproduction, many stages embryonic and fetal morphological development are poorly understood, with no apparent single source comprehensive information. Hence, the objective present study was to provide a complete macroscopic microscopic description embryo/fetus at various gestational ages. Thirty-four embryos/fetuses were aged based on their crown rump length (CRL), submitted description, biometry, light scanning microscopy, as well...
PURPOSE: To evaluate different protocols to isolate stem cells from ovine umbilical cord blood and adipose tissue. METHODS: There were used 5 samples of perirenal tissue 10 female sheep. All the obtained through surgery, harvest aseptic samples. 3 for obtainment culture 4 cells. RESULTS: It was possible observe only one successful protocol When analyzing techniques obtain cells, methods effective as well. Through colony forming unit assay, there 58 colonies after seven days in culture. Flow...
Abstract Background The repair of large bone defects is a major orthopedic challenge because autologous grafts are not available in amounts and harvesting often associated with donor-site morbidity. Considering that marrow stromal cells (BMSC) responsible for the maintenance turnover throughout life, we investigated at site critically sized segmental defect sheep tibia treated BMSCs loaded onto allografts. was created mid-portion tibial diaphysis eight adult sheep, were ex-vivo expanded...
Abstract: Amnion-derived mesenchymal stem cells (AMSCs) are multipotent with an enhanced ability to differentiate into multiple lineages. AMSCs can be acquired through noninvasive methods, and therefore exempt from the typical ethical issues surrounding cell use. The objective of this study was isolate characterize a cat amniotic membrane for future application in regenerative medicine. were harvested after mechanical enzymatic digestion amnion. In culture medium, adhered plastic dish...
Mesenchymal stem cells (MSCs) due to their self-renewal potential and differentiation capacity are useful for tissue regeneration. Immunomodulatory trophic properties of MSCs were demonstrated suggesting use as medicinal signaling able positively change local environment in injured tissue. Equine endometrosis is a progressive degenerative disease responsible glandular alterations endometrial fibrosis which causes infertility mares. More precisely, this characterized by phenotypic changes the...
There are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective this pre-clinical protocol was to evaluate grafting hydroxyapatite/tricalcium phosphate (BCP) ceramic biomaterial (B; QualyBone BCP®, QualyLive, Amadora, Portugal) together with heterologous fibrin biopolymer (FB; CEVAP/UNESP Botucatu, Brazil) and photobiomodulation (PBM; Laserpulse®, Ibramed, Amparo, repair process Fifty-six rats were randomly...
The application of decellularized scaffolds for artificial tissue reconstruction has been an approach with great therapeutic potential in regenerative medicine. Recently, biomimetic ovarian was proposed to reestablish endocrine functions. Despite many decellularization methods proposed, there is no established protocol whole ovaries by detergent perfusion that able preserve macro and microstructure higher efficiency. This generated biomaterial may have the be applied other purposes beyond...
The shortage of tissues and damaged organs led to the development tissue engineering. Biological scaffolds, created from extracellular matrix (ECM) tissues, have emerged as a promising solution for transplants. ECM decellularized auricular cartilage is potential tool producing ideal scaffolds recellularization implantation new in areas. In order be classified an scaffold, it must acellular, preserving its proteins physical characteristics necessary cell adhesion. This study aimed develop...
South American camelids inhabit high-altitude environments characterized by hypoxia, influencing embryonic, fetal, and placental development. This study examined the term placenta morphology of alpacas (Vicugna pacos, N = 12) immunoexpression antioxidant selenoproteins (SP). We hypothesize that alpacas, adapted to high altitudes, has characteristics with other species also altitude. Placentas were paraffin-embedded, sectioned (3–5 µm), stained hematoxylin–eosin (H&E), Masson’s trichrome,...