A5027028725- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Renal and related cancers
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Genomic variations and chromosomal abnormalities
- Corneal Surgery and Treatments
- Machine Learning in Bioinformatics
- Gene expression and cancer classification
- Congenital Anomalies and Fetal Surgery
- Reproductive Health and Technologies
- Banana Cultivation and Research
- Genetics, Bioinformatics, and Biomedical Research
- Muscle Physiology and Disorders
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Cancer and Skin Lesions
- Corneal surgery and disorders
- Birth, Development, and Health
- Forensic and Genetic Research
- Head and Neck Anomalies
Universidade de Mogi das Cruzes
2019-2021
Instituto Butantan
2006-2021
Universidade de São Paulo
2012-2016
Centro de Reprodução Humana Prof. Franco Junior
2006-2009
Universidade Federal de São Paulo
2007
Centro de Epilepsia y Neurocirugía Funcional
2007
Abstract Background The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at future treatment of human Duchenne (DMD). We have obtained a rare litter six GRMD (3 males and 3 females) born from an affected male carrier female which were submitted to trial with adult stem cells investigate their capacity engraft into muscles by local as compared systemic injection without any immunosuppression. Methods Human Immature Dental...
Pioneer work in male mouse embryonic stem (ES) cells differentiation into germ (GC) showed generations of or female gametes separate experiments, using genetically manipulated preselected ES cells. In an attempt to produce both types from without any genetic manipulation preselection, we induce the by retinoic acid (RA) within nonadherent embryoid bodies (EB). It seems that gamete-like cell formation occurs correct manner based on expression early and late GC-specific genes such as Oct-4,...
In this study, we aimed at determining whether human immature dental pulp stem cells (hIDPSC) would be able to contribute different cell types in mouse blastocysts without damaging them. Also, analysed these progress further into embryogenesis when implanted the uterus of foster mice, and develop human/mouse chimaera with retention hIDPSC derivates their differentiation.
Abstract Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and testing toxicity. Furthermore, these be used to address issue differential response, a phenomenon greatly influenced by genetic factors. This application depends on availability hPSC lines from populations with diverse ancestries. So far, it has been reported that most hPSCs derived worldwide are European or East Asian We...
About 7 % of karyotypically balanced chromosomal rearrangements (BCRs) are associated with congenital anomalies due to gene or regulatory element disruption, and cryptic imbalances on rearranged chromosomes. Rare familial BCRs segregating clinical features a powerful source for the identifying causative genes presence several affected carriers. We report translocation t(2;22)(p13;q12.2) variable learning disabilities, craniofacial hand dysmorphisms, detected in six individuals...
Aneuploid embryos diagnosed by FISH-based preimplantation genetic screening (PGS) have been shown to yield euploid lines of human embryonic stem cells (hESCs) with a relatively high frequency. Given that the diagnostic procedure is usually based on analysis 1–2 blastomeres 5 10-cell cleavage-stage embryos, mosaicism has likely explanation for phenomena. However, PGS can significant rate misdiagnosis, and therefore some those may derived from misdiagnosed as aneuploid. More recently, coupling...
The study of genetic changes is regarded as being paramount importance, since it can yield a greater understanding the expression and its consequences, such as: anticipated forecast certain types diseases. task identifying in DNA sequence (deoxyribonucleic acid), hitherto not described after next generation sequencing analysis has become one main activities bioinformatics due to capacity analyze interpret wide range data. Numerous software applications were designed for purposes aligning,...