A5053724714- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Genetic and Kidney Cyst Diseases
- vaccines and immunoinformatics approaches
- Genetic Syndromes and Imprinting
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Retinal Development and Disorders
- RNA Interference and Gene Delivery
- Blood disorders and treatments
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Infective Endocarditis Diagnosis and Management
- Retinal Diseases and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Autoimmune and Inflammatory Disorders Research
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- Digestive system and related health
- Connective tissue disorders research
- Magnesium in Health and Disease
Tehran University of Medical Sciences
2016-2025
Marymount University
2016
Recurrent abnormalities in immune surveillance-related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate response to therapeutic interventions. CD58 interacts with CD2 receptor on T cells NK is recurrently mutated deleted DLBCL, suggesting that it may play a role regulating antitumor immunity. In this study, we comprehensively analyzed genomic characteristics through targeted next-generation sequencing, RNA sequencing (RNA-seq), whole-exome single-cell...
Follicular lymphoma (FL), the most common indolent lymphoma, is a clinically and genetically heterogeneous disease. However, prognostic value of driver gene mutations copy number alterations has not been systematically assessed. Here, we analysed clinical-biological features 415 FL patients to identify variables associated with disease progression within 24 months first-line therapy (POD24). Patients B symptoms, elevated lactate dehydrogenase β2-microglobulin levels, unfavourable baseline...
Caspase-8 is a molecule in the FAS pathway that initiates apoptosis. One of rarest autoimmune lymphoproliferative syndromes caspase-8 deficiency. Immunodeficiency, splenomegaly, and lymphadenopathy are common symptoms this condition.A two-year-old boy entered study with fever unknown origin (FUO) dysentery. Moreover, he suffered from failure to thrive was allergic cow's milk protein. His dysentery did not respond antibiotic therapy. The colonoscopy revealed diffuse ulcerations regions...
Adenosine deaminase deficiency 2 (DADA2) is an autoinflammatory disorder, caused by the
CD27 is a costimulatory receptor involved in the maturation of innate and adaptive immunity. CD27, through interaction with CD70, plays role control Epstein-Barr virus (EBV) infection. deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients primary immunodeficiency at risk for adverse outcomes. Chromogenic situ hybridization (CISH) study was performed detect lymphoma tissue....
Prostate cancer is one of the most common cancers which develops by mutations and/or other genetic alterations in specific genes. Regarding previous studies literature predominant take place KRAS, BRAF, and EGFR genes special types cancers. In this research, we attempt to identify prevalence significant role possible exons 18-21, KRAS codon 12, 13, 61, BRAF 600 tumoral tissue specimens from patients with prostatic adenocarcinoma. Furthermore, it has been attempted investigate molecular...
Summary Primary gastrointestinal follicular lymphoma (PGI‐FL) is a rare extra‐nodal lymphoma. Its epidemiology and prognosis remain unclear. We performed retrospective analysis of eligible patients with 1648 PGI‐FL 34 892 nodal FL (N‐FL) in the Surveillance, Epidemiology End Results (SEER) database. The age‐adjusted average annual incidence was 0.111/100000. median overall survival (OS) for N‐FL 207 165 months respectively. 5‐year diffuse large B‐cell (DLBCL) transformation rates were 2.1%...
Succinyl-CoA:3-oxoacid CoA-transferase (SCOT) deficiency is an inborn error of ketone body utilization characterized by intermittent ketoacidosis crises. This study reports the first Iranian patient with SCOT who presented seizure and hypotonia at birth. Accordingly, she was consequently re-hospitalized due to respiratory distress. Laboratory tests revealed hyperammonemia, ketonuria, metabolic acidosis. Besides, plasma glucose level normal without any other abnormality. Despite treatment...
Bardet-Biedl syndrome (BBS) is an autosomal recessive pleiotropic ciliopathy, which includes multi-organ clinical manifestations. The known genes involved in the development of disease account for causality about 80% examined cases.We investigated two Iranian unrelated clinically diagnosed BBS patients, using a targeted next-generation sequencing panel consisting 18 genes. detected variants were pedigree and studied silico tools their pathogenicity. Patients' phenotypes also assessed.Novel...
<div>Abstract<p>Recurrent abnormalities in immune surveillance–related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate response to therapeutic interventions. CD58 interacts with CD2 receptor on T cells NK is recurrently mutated deleted DLBCL, suggesting that it may play a role regulating antitumor immunity. In this study, we comprehensively analyzed genomic characteristics <i>CD58</i> through targeted next-generation sequencing, RNA...
<div>Abstract<p>Recurrent abnormalities in immune surveillance–related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate response to therapeutic interventions. CD58 interacts with CD2 receptor on T cells NK is recurrently mutated deleted DLBCL, suggesting that it may play a role regulating antitumor immunity. In this study, we comprehensively analyzed genomic characteristics <i>CD58</i> through targeted next-generation sequencing, RNA...
<p>Supplementary Figures and Tables</p>
<p>Supplementary Figures and Tables</p>
Dilated cardiomyopathy (DCM) is a progressive heart condition characterized by left ventricular chamber enlargement associated with systolic failure and prolonged action potential duration. Genetic variations in genes that encode cytoskeleton, sarcomere, nuclear envelope proteins are responsible for 45% of cases. In our study, we focused on pedigree familial DCM to decipher the genetic cause(s) affected members developing arrhythmia, end-stage failure, sudden death.Whole-exome sequencing...
Background: The human leukocyte antigen-DRB1 (HLA-DRB1) locus is one of the most polymorphic loci and has a crucial role in immune system. Assessing allelic frequencies HLA-DRB1 would be fundamental factor defining origin populations, relationships with other disease association studies constitution unrelated bone marrow donor registries. In current study alleles their are determined family-based by DNA sequencing-based typing high-resolution (2 field) level typing. Materials Methods:...