A5100335740- Autophagy in Disease and Therapy
- Microstructure and mechanical properties
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Fusion materials and technologies
- Chemotherapy-induced cardiotoxicity and mitigation
- Erythrocyte Function and Pathophysiology
- Metal Forming Simulation Techniques
- Phagocytosis and Immune Regulation
- Macrophage Migration Inhibitory Factor
- High-Velocity Impact and Material Behavior
- Ubiquitin and proteasome pathways
- Inflammatory mediators and NSAID effects
- Advanced materials and composites
- Cancer Mechanisms and Therapy
- Calcium signaling and nucleotide metabolism
- Mechanisms of cancer metastasis
- ATP Synthase and ATPases Research
- Lysosomal Storage Disorders Research
- Nuclear Materials and Properties
- Epigenetics and DNA Methylation
- Microstructure and Mechanical Properties of Steels
Hebei Medical University
2023-2025
Second Hospital of Hebei Medical University
2025
Peking University
2016-2024
Fourth Hospital of Hebei Medical University
2023-2024
State Key Laboratory of Turbulence and Complex Systems
2023
Central South University
2020
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
<title>Abstract</title> Acute myeloid leukemia (AML) as the second most common hematological malignancy remains currently incurable. In this study, we found protein disulphide isomerase family (PDIs) was expressed in primary cells, with particular emphasis on ERP5 and ERP57. The compound PACMA31 demonstrated ability to inhibit proliferation, enhance differentiation, exacerbate oxidative stress, induce apoptosis AML cells. RNA sequencing analysis revealed that impeded proliferation of cells...
Recent studies have shown that anti-ERp5 antibodies inhibit platelet activation and thrombus formation; Moreover, ERp5-deficient platelets exhibit enhanced reactivity via regulation of endoplasmic reticulum (ER) stress. In this study, we used a new ERp5-knockout mouse model as well recombinant ERp5 (rERp5) protein, to examine the role in function thrombosis. Although platelet-specific mice had decreased count, shortened tail-bleeding times accumulation FeCl3-induced mesenteric artery injury,...
Abstract Autophagy is a highly inducible system of intracellular degradation that occurs in lysosomes or vacuoles. Transmembrane 74 (TMEM74) has been shown to induce autophagy. However, the mechanism by which TMEM74 stimulates autophagy and impacts TMEM74-induced on tumor cell survival remain unclear. In this study, was increase autophagic flux process different lines. Further investigations revealed interacts with ATG16L1 ATG9A. Moreover, distinctive from common models, it found...
Deformation-induced martensitic transformation (DIMT) is commonly reported to be easily activated in irradiated materials, but the existing kinetics models of DIMT hardly capture irradiation effect. In this work, we develop a model considering effect hardening, shear band evolution and role irradiation-induced voids. A crystal plasticity framework incorporating newly developed established. We show that capable capturing accelerated martensite volume fraction both cases with without Moreover,...
Objective Researches have identified ATPase H+ transporting V0 subunit d2 (ATP6V0D2) as a significant factor in various cancers. However, its prognostic value breast cancer (BRCA) and biological role BRCA cells remain unclear. Methods In this research, we examined the varying expression levels of ATP6V0D2 both normal tissue by utilizing information derived from databases including Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), along with clinical samples. Survival studies were...
Abstract Triple‐negative breast cancer (TNBC) has an aggressive clinical course, and paclitaxel (PTX)‐based chemotherapy remains the main therapeutic drug. Metadherin (MTDH) acts as oncogene that regulates proliferation, invasion, metastasis, chemoresistance. This study aimed to investigate whether TNBC chemosensitivity PTX was related MTDH/AKT/glycogen synthase kinase‐3beta (GSK‐3β) pathway. Clinical baseline characteristics immunohistochemistry (IHC) were used evaluate expression prognosis...
To theoretically analyse how void swelling and spatial heterogeneity impact the fracture behaviour of metallic materials, a coupled porous crystal plasticity framework has been developed. The proposed is then applied to materials under different conditions types heterogeneity. It revealed that at low porosity, voids will have limited influence on material. However, high owing swelling, concentrated distribution near grain boundaries can lead strong deformation localization, which be seen as...