A5047779583- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Functional Brain Connectivity Studies
- Hereditary Neurological Disorders
- RNA regulation and disease
- AI in cancer detection
- Barrier Structure and Function Studies
- COVID-19 and Mental Health
- Advanced Optical Sensing Technologies
- Sleep and related disorders
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Cerebral Palsy and Movement Disorders
- Seismic Imaging and Inversion Techniques
- Ultrasound Imaging and Elastography
- Connexins and lens biology
- Herpesvirus Infections and Treatments
- Image Processing Techniques and Applications
Second Xiangya Hospital of Central South University
2017-2024
Central South University
2017-2024
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
Herpes simplex encephalitis (HSE) caused by herpes virus 1 (HSV-1) infection can lead to a high mortality rate and severe neurological sequelae. The destruction of the blood-brain barrier (BBB) is an important pathological mechanism for development HSE. However, specific underlying BBB remains unclear. Our previous study found that Golgi apparatus (GA) plays crucial role in maintaining integrity BBB. Therefore, this present aimed investigate GA its mechanisms. Mouse brain endothelial cells...
White matter (WM) disruption is an important determinant of cognitive impairment after mild traumatic brain injury (mTBI), but traditional diffusion tensor imaging (DTI) shows some limitations in assessing WM damage. Diffusion kurtosis (DKI) and neurite orientation dispersion density (NODDI) show advantages over DTI this respect. Therefore, we used these three models to investigate complex changes the acute stage mTBI. From 32 mTBI patients 31 age-, sex-, education-matched healthy controls,...
Differential tractography and correlation are new modalities to study neuronal changes in brain diseases, but their performances detecting injuries yet be investigated patients with mild traumatic injury (mTBI). Here we the white matter mTBI using differential tractography. The diffusion MRI was acquired at 33 31 health controls. 7 of had one-year follow-up scans, used evaluate injured fiber bundles on these patients. All subjects were evaluated digital symbol substitution test (DSST) trail...
A chronic phase following repetitive mild traumatic brain injury can present as encephalopathy in some cases, which requires a neuropathological examination to make definitive diagnosis. Positron emission tomography (PET) is molecular imaging modality that has high sensitivity for detecting even very small changes, and be used quantitatively measure range of biological processes the using different radioactive tracers. Functional changes have also been reported patients with forms injury,...
Differential diagnosis of demyelinating diseases the central nervous system is a challenging task that prone to errors and inconsistent reading, requiring expertise additional examination approaches. Advancements in deep-learning-based image interpretations allow for prompt automated analyses conventional magnetic resonance imaging (MRI), which can be utilized classifying multi-sequence MRI, thus may help subsequent treatment referral.Imaging clinical data from 290 patients diagnosed with...
We evaluated the fiber bundles in mild traumatic brain injury (mTBI) patients using differential and correlational tractography a longitudinal analysis. Diffusion MRI data were acquired 34 mTBI at 7 days (acute stage) 3 months or longer (chronic after mTBI. Trail Making Test A (TMT-A) Digital Symbol Substitution changes used to evaluate cognitive performance. Longitudinal showed decreased anisotropy corpus callosum during chronic stage. The significantly correlated with TMT-A (false...
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system. However, whether and how cortical changes occur in NMOSD with normal-appearing brain tissue, or any correlate clinical characteristics, not completely clear. The current study recruited 43 patients who had tissue 45 healthy controls matched for age, sex, educational background from December 2020 to February 2022. A surface-based morphological analysis high-resolution...
The clinical manifestations and effects on the brain of SARS-CoV-2 Omicron variant in acute postinfection phase remain unclear.To investigate pathophysiological mechanisms underlying symptoms changes to gray matter subcortical nuclei among male patients after infection provide an imaging basis for early detection intervention.In this cohort study, a total 207 men underwent health screening magnetic resonance scans between August 28 September 18, 2022; them, 98 provided complete...
Mild traumatic brain injury (mTBI) is a known risk factor for neurodegenerative diseases, yet the precise pathophysiological mechanisms remain poorly understand, often obscured by group-level analysis in non-invasive neuroimaging studies. Individual-based method critical to exploring heterogeneity mTBI. We recruited 80 mTBI patients and 40 matched healthy controls, obtaining high-resolution structural MRI constructing Individual Differential Structural Covariance Networks (IDSCN)....
Morphometric changes in cortical thickness (CT), surface area (CSA), and volume (CV) can reflect pathological after acute mild traumatic brain injury (mTBI). Most previous studies focused on CT, CSA, CV subacute or chronic mTBI, few have examined mTBI. Furthermore, mTBI patients typically show transient cognitive impairment, reported the relationship between cerebral morphological function with This prospective cohort study included 30 (15 males, 15 females, mean age 33.7 years) 27 matched...
We aim to leverage deep learning develop a computer aided diagnosis (CAD) system toward helping radiologists in the of follicular thyroid carcinoma (FTC) on ultrasonography.A dataset 1159 images, consisting 351 images from 138 FTC patients and 808 274 benign follicular-pattern nodule patients, was divided into balanced unbalanced dataset, used train test CAD based transfer residual network. Six participated experiments verify whether how much proposed helps improve their performance.On...
To analyze clinical associations between Guillain-Barré syndrome (GBS) and trauma.We retrospectively reviewed the data of eight patients with post-traumatic GBS July 2011 December 2018 at Second Xiangya Hospital, China, analyzed triggers, manifestation, examination results, treatment, prognosis, potential mechanism related to GBS.The included had preceded by no risk factors other than trauma. Their age ranged from 15 60 years (the median was 52 years), six were males. The traumatic triggers...
Abstract JOURNAL/nrgr/04.03/01300535-202407000-00035/figure1/v/2023-11-20T171125Z/r/image-tiff Patients with mild traumatic brain injury have a diverse clinical presentation, and the underlying pathophysiology remains poorly understood. Magnetic resonance imaging is non-invasive technique that has been widely utilized to investigate neurobiological markers after injury. This approach emerged as promising tool for investigating pathogenesis of Graph theory quantitative method analyzing...
Parkinson's disease (PD) is a neurodegenerative movement disorder mainly due to degeneration of dopaminergic neurons in the substantia nigra. Most PD cases are sporadic and only 5%-10% patients carry mutations with inheritance. Among them, mutation DJ-1 related autosomal recessive early-onset parkinsonism. DJ-1, disease-related protein, plays important roles different physiopathological processes, including oxidative stress, cell translocation regulation transcription translation. known be...