A5062452837- Head and Neck Surgical Oncology
- Single-cell and spatial transcriptomics
- Ear and Head Tumors
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Underwater Vehicles and Communication Systems
- Bladder and Urothelial Cancer Treatments
- Tumors and Oncological Cases
- Privacy, Security, and Data Protection
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
Eye & ENT Hospital of Fudan University
2023-2024
China Electronics Standardization Institute
2024
Anhui Medical University
2024
University of South China
2024
Currently, only 20-40% of cancer patients benefit from immune checkpoint inhibitors. Understanding the mechanisms underlying immunosuppressive tumor microenvironment (TME) and characterizing dynamic changes in immunological landscape during treatment are critical for improving responsiveness to immunotherapy. Here, we identified JNK signaling cancer-associated fibroblasts (CAFs) as a regulator microenvironment. Single-cell RNA sequencing bladder treated with inhibitor revealed enhanced...
Summary Olfactory neuroblastoma (ONB) is an uncommon malignant tumor known to originate from the olfactory epithelial. The complex ecosystem of this pathology remained unclear. Here, we explored cellular components with ONB tumors based on scRNA profiles 96,325 single-cells derived 10 and 1 mucosa sample. We discovered 11 major cell types, including 6 immune cell, 3 stromal subtypes epithelial cluster in microenvironment (TME), identified 5 common expression programs cells. analyzed...