A5089509692- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Drug Transport and Resistance Mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Immune Cell Function and Interaction
- Heat Transfer and Optimization
- Pharmacological Effects and Toxicity Studies
- T-cell and B-cell Immunology
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Geothermal Energy Systems and Applications
- Ion Transport and Channel Regulation
- Fungal and yeast genetics research
- vaccines and immunoinformatics approaches
Kyushu University Hospital
2024
Saga University
2024
Kyushu University
1993-2022
Saiseikai Fukuoka General Hospital
2019-2021
Kumamoto Orthopedic Surgery Hospital
2018
Osaka City University
2017
Kumamoto University
2008
Kumamoto University Hospital
2007
Kyoto Bunkyo University
1998
Kyoto University
1998
The hedgehog (Hh) signaling pathway is activated in various types of cancer including pancreatic ductal adenocarcinoma. It has been shown that extremely low oxygen tension (below 1% O 2 ) found tumor tissue adenocarcinoma cells (PDAC) and increases the invasiveness PDAC. To investigate contribution Hh to hypoxia‐induced invasiveness, we examined how hypoxia affects activation In present study, three human PDAC lines were cultured under normoxic (20% or hypoxic (1% conditions. Hypoxia...
Dendritic cell (DC) maturation induced by Toll-like receptor agonists requires activation of downstream signal transduction and metabolic changes. The endogenous metabolite citrate has recently emerged as a modulator DC activation. However, the requirements that support production remain poorly defined. Here, we demonstrate p32/C1qbp, which functions multifunctional chaperone protein in mitochondria, supports mitochondrial metabolism maturation. Metabolic analysis revealed increase...
Precise biomarkers for predicting the therapeutic efficacy of molecularly targeted drugs are limited at protein level; thus, it has been important to broadly scrutinize individual cancer driver gene mutations effective treatments. Multiplex genome profiling can comprehensively identify that targets using next-generation sequencing (NGS). In addition, circulating tumor DNA (ctDNA) is a fragment released into blood by cell-derived cell death or apoptosis. Liquid biopsy with ctDNA novel...
In the proximal tubules of rat (r) kidney, polyspecific organic cation transporters (OCTs), rOCT1 and rOCT2, mediate baso-lateral uptake various cations, including many drugs, toxins, endogenous compounds, apical type H<sup>+</sup>/ antiporter, multidrug toxin extrusion 1 (rMATE1), efflux cations. Renal clearances H<sub>2</sub> receptor antagonists, famotidine, were reported to be decreased in patients with kidney disease. Therefore, acute injury (AKI) could influence renal excretion...
Chemorefractory ovarian cancer has limited therapeutic options. Hence, new types of treatment including neoantigen-specific immunotherapy need to be investigated. Neoantigens represent promising targets for personalized immunotherapy. We here describe the clinical and immunological effects a neoantigen peptide-loaded DC-based in patient with recurrent chemoresistant cancer. A 71-year-old female chemorefractory malignant ascites received intranodal vaccination DCs loaded four peptides that...
Abstract Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses the microenvironment remains unclear breast cancer. We performed whole exome and RNA sequencing of 31 fresh cancer tissues neoantigen prediction single nucleotide variants (nsSNVs) among exonic mutations. Neoantigen profiles were determined by predictive HLA binding affinity (IC 50 < 500 nM) mRNA expression with a read count ≥ 1. evaluated...
Multistage refrigeration systems are investigated to /enhance the performance of vapor compression cycles based on our previous work multistage low-grade thermal energy conversion. A double-stage heat pump and (D-S) is expected reduce irreversible loss in exchange process. However, certain characteristics independently configured systems, namely, compressor power coefficients (COPs), have not been sufficiently clarified. This study aims elucidate highly advanced by comparing D-S, a basic...
An in vitro organotypic culture model is needed to understand the complexities of carcinoma tissue consisting cells, stromal and extracellular matrices. We developed a new using rotary cell system with four disposable vessels (RCCS-4D) that provides simulated microgravity condition. Solid collagen gels containing human pancreatic NOR-P1 cells fibroblasts or minced were cultured under condition static Ig for seven days. cultures subjected showed greater numbers mitotic, cycling...
In 2018, BRACAnalysis® was covered by medical insurance in Japan as a companion diagnostic test for the poly ADP-ribose polymerase inhibitor olaparib. April 2020, eligibility BRCA1/2 genetic testing expanded to diagnosis of hereditary breast and ovarian cancer syndrome, management including prophylactic surgery surveillance were public mutation carriers who developed or cancer. The amount has been increasing recently, but number subjects impact patients' outcomes remain unclear.This study...
Abstract Introduction PREDICT is a prognostication tool that calculates the potential benefit of various postsurgical treatments on overall survival (OS) patients with nonmetastatic invasive breast cancer. Once patient, tumor, and treatment details have been entered, will show estimated 5‐, 10‐, 15‐year OS outcomes, both without adjuvant therapies. This study aimed to conduct an external validation version 2.2 by evaluating its predictive accuracy 5‐ 10‐year outcomes among female cancer in...
<i>Background:</i> Peritoneal defects lead to serious postoperative problems. Thus the development of physiological material cover peritoneal is very desirable. <i>Aim:</i> The aim this study was develop a transplantable artificial peritoneum. <i>Method:</i> peritoneum consisted collagen gel, fibroblasts, and mesothelial cells, histological features were analyzed. at site defect in rat transplanted abdominal wall. <i>Results:</i> Histological...
<h3>Abstract</h3> Background/Aim: Neoantigens are tumor-specific antigens that emerge due to gene mutations in tumor cells, and highly antigenic epitopes escape central immune tolerance the thymus, making cancer vaccine therapy a desirable option. Patients Methods: Tumor neoantigens were predicted 17 patients with advanced cancer. They resistant standard treatment regime, their synthetic peptides pulsed patient's monocyte-derived dendritic cells (DCs), administered lymph nodes via...
Beckwith-Wiedemann syndrome (BWS) is a genomic imprinting disorder caused by diverse genetic and/or epigenetic disorders of chromosome 11p15.5. BWS presents with variety clinical features, including overgrowth and an increased risk embryonal tumors. Notably however, reports patients breast tumors are rare, the association between these conditions still unclear. Insulin-like growth factor-2 (IGF2) expression known to be associated development various cancers, cancer, specific subtypes...
Abstract Introduction. The American Joint Committee on Cancer (AJCC) 8th edition of breast cancer classification introduced the concept "prognostic stage," which is based anatomic (TNM classification) plus four biomarkers: estrogen receptor (ER), progesterone (PR), human epidermal growth factor (HER2), and histological grading (HG). In Japan, however, introduction has been passive slow, nuclear (NG) used so far. Objective. Our aim to compare prognostic staging in AJCC, substitutes NG for HG...
2567 Background: We have already indicated that regulatory T cells (Treg) negatively control the antitumor immune response in colon cancer (Suzuki H et al: Cancer Immunol Immunother, press). also shown exosomes (Ex) secreted by monocyte-derived dendritic support naïve CD4+ T-cell survival via NF-κB activation (Matsumoto K Cell Immunol, 2004). Interestingly, our recent preliminary data suggest a possible contribution of malignant effusion-derived Ex (Eff-Ex) to increased number Treg...
Hereditary tumors are estimated to account for approximately 5-10% of all tumors. In Europe and the United States, multi-gene panel testing (MGPT) is standard method used identifying potential causative genes. However, MGPT it still not widely in Japan. The aim this study was assess risk hereditary Japanese cancer patients using germline provide an overview medical system.We myRiskTM, a 35-gene that determines eight cancers: breast, ovarian, gastric, colorectal, prostate, pancreatic,...
Incretin-based therapy consists of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists. Whether switching from DPP-4 to one the GLP-1 agonists, dulaglutide, has greater beneficial effects remains unknown. Therefore, this study aimed investigate effectiveness dulaglutide in four patients with type 2 diabetes. All hyperglycemia who switched demonstrated noticeable decreased plasma glucose levels on next day after switching. Two observed maintained a...
The DNA-breaking and DNA-breakage-inhibiting activities of 23 steroids (bile acids, steroid hormones, neutral sterols, oxidized cholesterols) were measured in vitro. No compounds examined broke DNA, but some bile acids such as taurocholic, lithocholic, ursodeoxycholic, chenodeoxycholic, hyocholic. inhibited DNA breakage by ascorbic acid. Taurocholic acid had the highest inhibiting activity at concentrations above 10mmol, its constituents, taurine cholic acid, no activity. On contrary,...