The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 1.0% levels significantly decreased the liver cholesterol level compared with that control (AP-free diet-fed) group. also lowered serum However, HDL was higher AP-fed group than...

We examined the effects of intake Korean foxtail millet protein (FMP) on plasma levels lipid, glucose, insulin, and adiponectin in genetically type 2 diabetic KK-Ay mice. When mice were fed a normal FMP diet or high-fat-high-sucrose containing for 3 weeks, both experiments concentrations high-density lipoprotein cholesterol (HDL-cholesterol) increased remarkably comparison with casein group, whereas insulin decreased greatly that glucose was comparable to group. Considering role adiponectin,...

The absorption of cholesterol and oxidation products (oxidized cholesterols) was compared in lymph-cannulated rats. We found that the lymphatic an intragastrically administered, emulsified lipid meal containing 25 mg or oxidized cholesterols, within 24 h, approximately 67 30%, respectively. rate individual cholesterols differed considerably 30% for 7 alpha-hydroxycholesterol, 42% beta-hydroxycholesterol, 32% 5 beta-epoxycholesterol, 28% alpha-epoxycholesterol, 15% cholestanetriol 12%...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of cholesterol by heatingKyoichi. Osada, Takehiro. Kodama, Koji. Yamada, and Michihiro. SuganoCite this: J. Agric. Food Chem. 1993, 41, 8, 1198–1202Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/jf00032a006https://doi.org/10.1021/jf00032a006research-articleACS PublicationsRequest reuse permissionsArticle Views875Altmetric-Citations59LEARN...

The levels of cholesterol oxidation derivatives (OxChol) in eight commercial species meat products were examined. These contained more than 1 mg/100 g OxChol, and 7β-hydroxycholesterol + 5β-epoxycholesterol (111−1092 μg/100 g), 5α-epoxycholesterol (80−712 cholestanetriol (0−368 7-ketocholesterol (708−1204 g) detected. To know the interaction sodium nitrite supplementation against products, sausage was produced with or without varying stored refrigerator for 15 days. As a result, inhibited by...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLevels and formation of oxidized cholesterols in processed marine foodsKyoichi. Osada, Takehiro. Kodama, Li. Cui, Koji. Yamada, Michihiro. SuganoCite this: J. Agric. Food Chem. 1993, 41, 11, 1893–1898Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jf00035a016https://doi.org/10.1021/jf00035a016research-articleACS PublicationsRequest reuse...

Aim: No prior studies have investigated the effects of dietary cholesterol oxidation products (oxysterols) on atherosclerotic plaque destabilization and rupture. We used an mouse model with histological features similar to those seen in ruptured human plaques test hypothesis that (1) oxysterols accelerate rupture (2) a NPC1L1 inhibitor, ezetimibe, has therapeutic these processes.Methods Results: Advanced were examined innominate arteries ApoE-/- mice fed either regular high-fat diet (HFD) or...

Xanthohumol is the major prenylated flavonoid of female inflorescences hop plant (Humulus lupulus L.) and a hydrophobic flavonoid. We examined effects dietary xanthohumol-rich extract in obese rats that was induced by feeding high-fat diet. Dietary significantly lowered body weight gain these compared to fed diet without extract. The increase weight, liver triacylglycerol levels plasma ameliorated tended reduce hepatic fatty acid synthesis through reduction SREBP1c mRNA expression excreted...

Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined exogenous (PS) and growth parameters lipid rats. Rats were provided with AIN‐76 basal diet, diet +0.5% PS, or OPS. We found level cholesterol triacylglycerols liver was significantly lower OPS‐fed rats than diet‐fed The ratio Δ6 desaturation index (20:3(n‐6) +...

Exogenous and endogenous cholesterol oxidation products (COPs) perturb various metabolic processes, thereby they may induce homeostasis-related disorders. Here, we observed that procyanidin-rich dietary apple polyphenol (APP) from unripe apples alleviates the perturbation of lipid metabolism by decreasing exogenous COP levels in rats. Dietary COPs be greatest source found human body. Rats (4 weeks age) were fed AIN-purified diets containing 0.3% supplemented with 0.5 or 2.5% APP for 3 weeks....

We previously reported that ingestion of apple polyphenols reduced the weight visceral adipose tissue and triglyceride content blood liver in rats fed a high-fat diet (1). To further elucidate mechanism improvement lipid metabolism by dietary polyphenols, effects feeding apple- tea-derived catechins on hepatic gene expression profile was investigated using GeneChip DNA microarray system. Male Sprague-Dawley were normal diet, supplemented with 1.0% or tea for 9 weeks. Both liver. Tea...

Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) is the most common organic germanium compound. This compound has many physiological effects, which are mediated via modulation of immune-system activation. The intake dietary Ge-132 causes fecal color changes in humans, and we studied mechanism this a rodent model. Male Wistar rats were given diet containing 0.05% for two weeks compared with free diet. their feces cecal contents changed from grayish-green to yellow fed Ge-132....

We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high-fat diet through regulation of fatty acid metabolism. In this study, we examined the dietary purified xanthohumol from XRHE (PX, ~91.9% KK-Ay mice order to understand alone because contains 82% unknown compounds. Dietary consumption PX significantly inhibited an increase visceral fat weight compared those control without PX. Plasma leptin level was lower PX-fed group...

Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of hop plant (Humulus lupulus L.). In this study, we examined effects xanthohumol-rich extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on differentiation adipogenesis 3T3L1 cells. We observed that inhibited cells intracellular fat droplets via regulation adipogenic factors such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, adipocyte fatty...

Large amounts of procyanidins, made up catechin oligomers, are consumed on a daily basis via various plant-based diets. Recent studies show that tea polyphenol (TP) exerts anti-obesity effect; however, the biological functions procyanidins have not yet been established. In this study, we examined high dose effects from apple (AP), hop (HP), and obesity using normal Sprague-Dawley rats fat (HF) diet. We measured adipose tissue mass lipid parameters in polyphenol-free low (LF) (7%) or HF...

Male Sprague-Dawley rats, 4 weeks of age, were fed purified diets either with or without 0.2% soy isoflavones rich powder for 5 to elucidate their direct functions such as antioxidative action and regulation lipid metabolism. Dietary decreased serum peroxide level in rats. Levels liver alpha-tocopherol higher the rats isoflavone than those isoflavones-free diet. Thus, dietary exhibited mild function this animal experiment. Isoflavone metabolites from diet may act scavengers reactive oxygen...

Abstract The interactive effect of high dietary levels oxidized cholesterol on exogenous cholerterol and linoleic acid metabolism was examined in male 4‐wk‐old Sprague‐Dawley rats given high‐cholesterol diets. were pair‐fed purified diets free or containing either 0.5% alone both mixture (containing 93% cholesterol) for 3 wk. Hepatic 3‐hydroxy‐3‐methylglutaryl CoA reductase activity reduced cholesterol. However, hepatic 7α‐hydroxylase lowered only when cholesterol, although increased this...

Abstract For three weeks, male Sprague‐Dawley rats at either four weeks (young) or eight months (adult) of age were pairfed one the purified diets free containing 0.2% oxidized cholesterol mixture (cholesterol oxidation products) cholesterol. Although food intake was similar, dietary lowered body weight gain in young rats, but did not increase relative liver weight, contrast to enlargement seen with Oxidized cholesterol, compared tended reduce activity hepatic 3‐hydroxy‐3‐methylglutaryl CoA...

The degree of glyceride syntheses by lipase TOYO ( Chromobacterium viscosum ) and OF Candida cylindracea using individual free fatty acids C 18∶1 , 18∶2 18∶3 18∶4 20∶4 20∶5 22∶6 were compared. Lipase incorporated each the into glycerol at levels greater than 89%. most above 70% (docosahexaenoic acid incorporation was 63%). It concluded that these two lipases are feasible for producing glycerides from unsaturated acids.

The effects of fish oil for improving mental health have been reported. present study was undertaken to compare the eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) on anxiety-like behavior using a rat model. Experimental diets enriched in EPA or DHA as glycerides were prepared. Rats exposed social isolation stress fed experimental diet 14 days. results behavioral tests revealed that rats EPA-enriched exhibited less than control DHA-enriched diets. Furthermore, suppressed only socially...