A5039999589- Pediatric Hepatobiliary Diseases and Treatments
- Neutropenia and Cancer Infections
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Lesions and Carcinomas
- Vascular Tumors and Angiosarcomas
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Oral health in cancer treatment
- Genetic Syndromes and Imprinting
- Bladder and Urothelial Cancer Treatments
- Prenatal Screening and Diagnostics
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- DNA Repair Mechanisms
- Cancer and Skin Lesions
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
Kyushu University
2023-2024
Kyushu University Hospital
2024
Breast Center
2022
Hamanomachi Hospital
2019-2022
St Mary's Hospital
2019-2021
Precise biomarkers for predicting the therapeutic efficacy of molecularly targeted drugs are limited at protein level; thus, it has been important to broadly scrutinize individual cancer driver gene mutations effective treatments. Multiplex genome profiling can comprehensively identify that targets using next-generation sequencing (NGS). In addition, circulating tumor DNA (ctDNA) is a fragment released into blood by cell-derived cell death or apoptosis. Liquid biopsy with ctDNA novel...
Tumor-infiltrating lymphocytes in the tumor microenvironment are important treatment of triple-negative breast cancer (TNBC). Cytotoxic T cells produce cytokines and cytotoxic factors, such as perforin granzyme, which induce apoptosis by damaging target cells. To identify biomarkers these cells, we investigated granzyme B (GZMB) a biomarker response prognosis 230 patients with primary TNBC who underwent surgery without preoperative chemotherapy between January 2004 December 2014. Programmed...
Intracholecystic papillary neoplasm (ICPN) of the gallbladder is a rare tumor and relatively new concept. Therefore, natural history imaging characteristics ICPN have not yet been fully documented. Moreover, cases who underwent curative resection for remnant cancer, including with associated invasive carcinoma, rarely reported. We report resected case carcinoma which we could observe temporal change in findings until malignant transformation.A 79-year-old female patient surgical subtotal...
Beckwith-Wiedemann syndrome (BWS) is a genomic imprinting disorder caused by diverse genetic and/or epigenetic disorders of chromosome 11p15.5. BWS presents with variety clinical features, including overgrowth and an increased risk embryonal tumors. Notably however, reports patients breast tumors are rare, the association between these conditions still unclear. Insulin-like growth factor-2 (IGF2) expression known to be associated development various cancers, cancer, specific subtypes...
Abstract [Background] The effects of gut microbiome on various diseases have become widely known, and many studies reported that there was a correlation between the change microbiota, is dysbiosis, progression digestive tract cancer. In addition, it well-known microbiota correlated to efficacy immune checkpoint inhibitors for multiple types However, significance in patients with breast cancer still remains unclear. aim this study analyze cancer, compared healthy women. [Subjects Methods] We...
Abstract Background Biliary intraepithelial neoplasia (BilIN) is often distinguished by what it not: the precancerous lesions are not mass-forming, cause of bile duct obstruction, and small enough (less than 5 mm long) to evade detection naked eye. Here, we describe an atypical case BilIN resembling cholangiocarcinoma (CC) that was large be identified diagnostic imaging presented with obstructive jaundice caused a hematoma in common (CBD). Case presentation A 64-year-old man our hospital...
Abstract Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing have been reported in various organs such as the lung, esophagus, and stomach but rarely breast. We report a case malignant phyllodes tumor Case presentation An 84-year-old woman visited our hospital complaining lump her left breast without fever pain. Laboratory tests revealed elevated white blood cell (WBC) count G-CSF levels. A was...
Abstract Background: Many analyzes on tumor microenvironment has made it clear that infiltrating lymphocytes (TILs) plays an important role in treating cancers with high mutation burden such as triple-negative breast cancer (TNBC). We reported the relationship between TILs and PD-L1 expression (Oncotarget 2017) revealed high-TILs/positive-PD-L1 population TNBC was associated better prognosis. However, its molecular mechanism is still unclear. Meanwhile, well-known activated T-cells work...
急性胆石性膵炎は胆石が十二指腸乳頭部に嵌頓し膵管を閉塞することで引き起こされるが，胆石が主膵管内に迷入する例は非常に稀である．今回われわれは，総胆管結石が主膵管へ迷入し急性膵炎を発症した1例を経験した．症例は61歳の男性で心窩部痛を主訴に当院を紹介受診し，胆嚢・総胆管結石症の診断で後日内視鏡的切石予定であった．4日後再度心窩部痛が出現し当院へ救急搬送され，急性胆石性膵炎の診断で入院となった．CTで総胆管結石が膵管内へ移動している所見が疑われた．内視鏡的逆行性胆管膵管造影を施行したところ，胆管内に明らかな陰影欠損像は認めず，膵頭部主膵管内に陰影欠損を認め，胆管結石の膵管内迷入と診断した．膵管ステント留置により徐々に膵炎所見は改善し，腹腔鏡下胆嚢摘出術後に内視鏡的切石を行った．自然経過での膵管内迷入胆石は非常に稀でありこれまでに報告例はないが，急性膵炎の原因の一つとして常に念頭に置く必要がある．
血管脂肪腫は四肢や体幹の皮下組織に好発し,稀に乳房内にも発生する.他の腫瘤と鑑別を要することもある.今回,乳房内に発生した血管脂肪腫について報告する.症例は50歳,女性.前医の乳房エコーで左乳房内に腫瘤を指摘され,精査目的に当科紹介受診となった.左乳房C区域2時方向に圧痛を伴う1cm大の腫瘤を触知し,その他全身に腫瘤を認めなかった.マンモグラフィで左乳房MO領域に境界明瞭な高濃度腫瘤を認め,乳房エコーで左乳房C区域2時方向の皮下脂肪内に17×12×9mm大の境界不明瞭な低エコー腫瘤を認めた.針生検を施行し血管脂肪腫の診断であったため,腫瘤摘出術を施行した.病理結果は非浸潤型血管脂肪腫であった.血管脂肪腫の術前診断は各種画像検査を用いても困難とされている.乳房内に高エコー腫瘤を認めた場合は,血管脂肪腫を鑑別に挙げるべきであり,診断と治療を兼ねて外科的切除を行う必要があると考えられる.また,術後も慎重な経過観察が必要である.