A5101534915- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Veterinary Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Glycosylation and Glycoproteins Research
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Reproductive Biology and Fertility
- Liver Disease and Transplantation
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Environmental Impact and Sustainability
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- COVID-19 epidemiological studies
Himeji Red Cross Hospital
2017-2025
Azabu University
2025
Nagoya University
2020-2024
Japan Clinical Cancer Research Organization
2009-2023
Kanagawa Cancer Center
2021
Kanagawa Prefectural Hospital Organization
2021
Shiga University of Medical Science
2008-2019
Okayama University
1994-2018
Okayama University Hospital
2014-2017
National Cancer Center Hospital East
2015
A Phase III study was started in Japan to evaluate the non-inferiority overall survival of segmentectomy compared with lobectomy patients small-sized (diameter ≤2 cm) peripheral non-small cell lung cancer, excluding radiologically determined non-invasive cancer. This began August 2009, and a total 1100 will be accrued from 71 institutions within 3 years. The primary endpoint is survival. secondary endpoints are post-operative respiratory function, relapse-free survival, proportion local...
Purpose This phase III trial aimed to confirm the superiority of weekly docetaxel and cisplatin over monotherapy in elderly patients with advanced non–small-cell lung cancer (NSCLC). Patients Methods Chemotherapy-naïve stage III, IV, or recurrent NSCLC age ≥ 70 years a performance status 0 1 who were considered unsuitable for bolus administration randomly assigned receive 60 mg/m 2 on day 1, every 3 weeks, 20 plus 25 days 8, 15, 4 weeks. The primary end point was overall survival (OS)....
This study aimed to evaluate the long-term prognosis of patients with peripheral small ground-glass opacity-dominant lung cancer after sublobar resection. We have already reported 5-year safety and efficacy resection report outcomes a 10-year follow-up period.Between May 2009 April 2011, 333 radiologically noninvasive were enrolled from 51 institutions (median age, 62 years at registration) followed up until 6, 2021. Of these patients, resections wedge as first choice performed in 314 (258...
During the large epidemic of serogroups A and C meningococcal disease in Brazil, we studied immunologic response to polysaccharide vaccine infants born women vaccinated during pregnancy. Radioimmunoassay serum levels against were more than threefold higher unvaccinated at delivery. Cord blood also or whose mothers while pregnant compared mothers. Within 3 mo, infants' antibody declined by approximately 80%. When about 6 mo age, had responses vaccines indistinguishable from those The did not...
The social-distancing measures implemented as a result of the COVID-19 pandemic have changed socio-economic activities in urban areas. This study analyzes these behavioral changes four Japanese metropolitan areas based on mobility data provided by Google and Apple. results show that regular patterns behavior been significantly disrupted COVID-19, inhibition manifests differently depending upon structure climatic factors.
Rodents are widely used to study the toxicity of chemicals; however, differences between species indicate that results from rodents not always directly transferable humans. The health workers exposed various chemicals and particulates at high doses or for long periods is risk. Respiratory bronchioles lobular structures, which demarcated by interlobular septa, key sites occupational lung diseases such as pneumoconiosis; these structures vary among animal species. Understanding crucial...
ABSTRACT Aim We investigated the impact of proteinuria on therapeutic effect before lenvatinib administration as second‐line treatment after atezolizumab‐bevacizumab. Methods examined 64 patients who were administered discontinuation atezolizumab and bevacizumab. Proteinuria assessed was considered severe if qualitative value test (QV) 3+ or urine protein/creatinine ratio (UPCR) ≥ 2.0 (group A, n = 13) non‐severe UPCR < QV ≤ 2+ B, 51). Results In entire cohort, modified albumin–bilirubin...
H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against broad spectrum of viruses is preferable for pandemic preparedness. We established second candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), our library examined the efficacy inactivated whole particles this strain two clades HPAIV strains caused severe morbidity cynomolgus macaques. Virus propagation...
A c‐Met inhibitor tivantinib is a candidate anticancer agent for patients with hepatocellular carcinoma (HCC), and CYP2C19 the key metabolic enzyme tivantinib. Previous Japanese phase I studies in solid tumors (except HCC) recommend 360 mg twice daily (BID) 240 BID extensive metabolizers (EM) poor (PM), respectively. In this study, HCC whom sorafenib treatment has failed were enrolled to evaluate safety, tolerability pharmacokinetics of oral as single agent. The dose was escalated separately...
GH release decreases with aging in primates. However, it is unclear whether the age-related decrease due to a stimulatory GHRH or an increase inhibitory somatostatin (SS) from hypothalamus. In present study, we measured of and SS stalk-median eminence conscious aged (n = 7, 27.0 ± 0.7 yr old) young adult female monkeys 12, 5.0 0.3 using push-pull perfusion method. Mean levels during morning (0600–1200 h) evening (1800–2400 were 3- 4-fold lower than monkeys. Pulse analysis indicated that...
This trial report describes the background and design for Japan Intergroup Trial of Pemetrexed Adjuvant Chemotherapy Completely Resected Nonsquamous Non–Small-Cell Lung Cancer (JIPANG) study (University Hospital Medical Information Network database: UMIN000006737). Various randomized trials have shown efficacy postoperative adjuvant chemotherapy regimens that include cisplatin resected non–small-cell lung cancer (NSCLC), but optimal regimen is not known. The JIPANG a comparing (75 mg/m2, day...
This case report documents clinical and molecular findings in two littermate kittens of the Japanese domestic cat with GM2 gangliosidosis variant 0. Analysis included detailed physical, magnetic resonance imaging, biochemical, pathological genetic examinations. At first, these showed typical cerebellar signs at approximately 2 months age. About later, they progressively other neurological subsequently died about 7 Magnetic imaging just before death an enlarged ventricular system, T1...
A 17-year-old spayed female domestic shorthair cat was referred for evaluation of severe skin lesions, including ulceration, nodule formation, erythema, and alopecia. Cutaneous nonepitheliotropic lymphoma diagnosed histologically. There no evidence visceral organ involvement, but renal function decreased. The treated with lomustine (45.5 mg/m2, PO, q 21 d), lesions resolved after administration the third dose. No toxicoses were identified. Results suggest that may be useful treatment...
9598 Background: Superiority of palonosetron to granisetron is uncertain, for patients with breast cancer receiving both steroid and NK1 inhibitor against CINV caused by AC regimen. Methods: We conducted a randomized double-blind active-controlled study. 341 chemo-naïve treated regimen were 1:1 either (1) 0.75 mg + dexamethasone fosaprepitant or (2) 1mg fosaprepitant. Stratification factor was age ( < / > 55 yrs) type anthracycline (epirubicin doxorubicin). Patients recorded episodes emesis,...