A5022042146- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Long-Term Effects of COVID-19
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Eosinophilic Disorders and Syndromes
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis B Virus Studies
- Transportation Planning and Optimization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- RNA and protein synthesis mechanisms
- PARP inhibition in cancer therapy
- Biosimilars and Bioanalytical Methods
- Sepsis Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
Hokkaido University
2013-2025
Sapporo City General Hospital
2023-2025
Hokkaido University of Science
2024
Asahikawa City Hospital
2021-2022
Nagoya University
2018
Background Clinical characteristics, including laboratory parameters, of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant have been limited. Methods This retrospective case-control study was conducted in a single hospital. Patients with disease 2019 (COVID-19) who visited Asahikawa City Hospital outpatient department as new patients and underwent blood tests were included this study. We analyzed data from January 2022 to April during phase 2021 October Delta...
ABSTRACT Influenza A viruses with fewer amino acids in the neuraminidase (NA) stalk domain are primarily isolated from chickens rather than wild ducks, indicating that a shortened NA is considered an adaptation marker of avian influenza (AIVs) to chickens. Experimental passages H7N7 nonpathogenic AIV (rgVac2-P0) resulted highly pathogenic variant (Vac2-P3L4) 34-amino-acid deletion stalk, encompassing five potential N -glycosylation sites. To investigate how acid truncation and...
Patients with hematologic diseases have experienced coronavirus disease 2019 (COVID-19) a prolonged, progressive course. Here, we present clinical, pathological, and virological analyses of three cases prolonged COVID-19 among patients undergoing treatment for B-cell lymphoma. These had all been treated anti-CD20 antibody bendamustine. Despite various antiviral treatments, high severe acute respiratory syndrome 2 (SARS-CoV-2) levels persisted >4 weeks, two them succumbed to COVID-19. The...
The life cycle of EBV is regulated by epigenetic modifications, such as CpG methylation and histone modifications. Here, we found that the expression EZH2, which encodes a H3K27 methyltransferase, was induced infection; therefore, generated EZH2-KO cells to investigate role EZH2 in EBV-infected Akata B cells. Disruption resulted increased genes during lytic phase and, efficient viral replication progeny production. Our results shed light on mechanisms underlying reactivation from an point...
H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against broad spectrum of viruses is preferable for pandemic preparedness. We established second candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), our library examined the efficacy inactivated whole particles this strain two clades HPAIV strains caused severe morbidity cynomolgus macaques. Virus propagation...
Recent data from clinical trials suggest that antibody cocktail therapy, which combined casirivimab and imdevimab, is linked to the reduction of risk hospitalization or death among high-risk patients with COVID-19. However, it remains unclear how effective therapy in a real-life practice.We retrospectively analyzed COVID-19 factors who underwent compared those were not given while being isolated nonmedical facilities during same period.Data 55 received 53 initial isolation analyzed. A total...
BackgroundFrom late March through April 2021, we experienced a cluster of patients with COVID-19, named "Cluster K", rapid severe illness compared those who were infected before.MethodsPatients COVID-19 enrolled in this study divided into two groups: 66 from November 2020 to 2021 (group A) and 37 whose infection links traced Cluster K B). The primary outcome was mortality rate, the secondary maximal oxygen flow rate as severity disease. Viral genome sequences between groups.ResultsMortality...
Summary Prolonged SARS‐CoV‐2 infection in immunocompromised individuals has been scattered, but the details remain unclear. We conducted a prospective study with 26 COVID‐19 patients haematological malignancies to determine viral shedding kinetics and characteristics. obtained nasopharyngeal swabs from 21–28 days post‐onset for PCR test performed virus isolation PCR‐positive samples. A viable was detected five (19.2%), all of whom had malignant lymphoma. Those significantly lower CD4 +...
Primary haematological neoplasms of the larynx are uncommon; therefore, information regarding their epidemiology is limited and diagnosis histological types requires careful consideration. The current study describes case a 72‑year‑old male patient with primary laryngeal lymphoplasmacytic lymphoma (LPL) that was difficult to distinguish from plasmacytoma. Imaging examinations neck revealed mass in right folds, 25x12x25 mm size, which surgically resected by direct laryngoscopy....
Abstract Polybasic amino acid residues at the hemagglutinin (HA) cleavage site are insufficient to induce highly pathogenic phenotype of avian influenza viruses in chickens. In our previous study, an H7N7 virus named Vac2sub-P0, which is non-pathogenic despite carrying polybasic acids HA site, was passaged chick air sacs and a with high intravenous pathogenicity, namely, Vac2sub-P3, obtained. Intranasal infection Vac2sub-P3 only partially lethal chickens; therefore, this further chicken...
ABSTRACT Background Recent data from clinical trial suggest that antibody cocktail therapy, a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to rapidly reduce viral load markedly decrease risk hospitalization or death among high-risk patients with coronavirus disease 2019 (Covid-19). However, it remains unclear how effective in real-life setting therapy is. Methods We retrospectively analyzed mild moderate Covid-19 one more factors for severe who...
Previous research has suggested that some autoimmune diseases develop after the occurrence of coronavirus disease 2019. Hypereosinophilic syndrome is a rare presenting with idiopathic eosinophilia and multiple organ involvement, including skin, lungs, gastrointestinal tract, heart, nervous system. The diagnosis hypereosinophilic poses dilemma because clinical manifestation serum biomarkers are similar to those eosinophilic granulomatosis polyangiitis. Only few cases have been reported where...
Rapid characterization of the causative agent(s) during a disease outbreak can aid in implementation effective control measures. However, isolation from crude clinical samples be challenging and time-consuming, hindering establishment countermeasures. In present study, we used saliva specimens collected for diagnosis SARS-CoV-2-a good example practical target-and attempted to characterize virus within without isolation. Thirty-four coronavirus 2019 patients were extract RNA synthesize DNA...
Background: The incidence of non-B non-C hepatocellular carcinoma (NBNC-HCC), which is negative for hepatitis B surface antigen and C virus antibodies, on the rise. Relatively high numbers NBNC-HCC patients are core antibody (HBcAb) positive, suggesting that previous HBV infection may play a role in development, though exact mechanisms unclear. This study aimed to investigate whether genomes integrated into host genome HBcAb-positive cases how these integrations contribute cancer development...
In this paper we analyzed several traffic surveys and two types of questionnaires for execution park bus ride system in a big sports event Toyota city. From the Covariance Structure Analysis it indicated that waiting time travel shuttle influenced on satisfaction degree P&BR users evening sportsevent.
【背景】COVID-19に対するモノクローナル抗体 カシリビマブとイムデビマブの併用療法である抗体カクテル療法は海外の第3相試験において入院または全死亡を有意に減少させた．本邦においても，重症化リスクを有する軽症または中等症Iの患者に対し，2021年7月19日にその使用が特例承認されたが，実臨床での詳細な臨床経過についての報告はない．
大型施設の立地を検討する場合には、施設が呼び込む交通需要による影響分析を行い、周辺道路や施設への影響が軽微であることを示す必要がある。施設立地により発生する交通需要は、様々な要因によって大きくその性質・規模等が異なるため、検討施設の特性を考慮した影響評価手法を選定する必要がある。そこで本稿では、論文の前半で、交通影響評価に必要となる調査・分析を実施する際に検討すべきポイントや留意点を分析の基本的な流れに沿って示す。後半では、交通影響評価手法の一つである「交差点解析」に焦点を絞り、解析精度に大きく影響を及ぼす「飽和交通流率」の算出方法を事例とともに複数紹介し、各手法のメリット・デメリットを整理したうえで、検討内容や検討段階、業務全体の方向性を見据えた適切な計算手法を選定することの重要性を示した。
Abstract Among a cluster of COVID-19 cases from the end March through April 2021 in Asahikawa, we experienced which patients manifested severe clinical symptoms compared to who were infected before that. A hundred three (age range: 65 89 years old) enrolled this study divided into two groups, group A: November 2020 2021, and B: population. The mortality rates 6.1% 16.2% B (OR: 2.97, 95%CI: 0.65-15.38). For severity disease, required higher oxygen flow rate early course admission (mild;...
Abstract Background It is critical for clinicians seeing outpatients with coronavirus disease 2019 (COVID-19) to identify those who will require oxygen therapy after the hospital visit. Although studies on biomarkers predicting mortality or ventilator requirement in hospitalized patients COVID-19 have been conducted, research need sparse. Methods Patients visited Asahikawa City Hospital an outpatient basis were included study. In total, 287 new between April 2021 and September 2021, 142...