A5072628472- Vector-borne infectious diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Insect and Pesticide Research
- Fibroblast Growth Factor Research
- Phytochemical compounds biological activities
- Retinoids in leukemia and cellular processes
- Cholesterol and Lipid Metabolism
- Insect Pest Control Strategies
- Mosquito-borne diseases and control
- Heat shock proteins research
- Comparative Animal Anatomy Studies
- Kruppel-like factors research
- Metabolism and Genetic Disorders
- Plant Parasitism and Resistance
- Lysosomal Storage Disorders Research
- Toxin Mechanisms and Immunotoxins
- Bacterial Infections and Vaccines
- Regulation of Appetite and Obesity
- Cellular transport and secretion
- Glycosylation and Glycoproteins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Traditional and Medicinal Uses of Annonaceae
- Genetic Neurodegenerative Diseases
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2024
Chikamori Hospital
1998-2024
Hoshi University
2010-2023
Iwate University
2016-2021
Kyoto Pharmaceutical University
1996-2019
Kyoto University
1996-2019
Ebara (Japan)
2005-2017
Ise Red Cross Hospital
2017
Hokkaido University
2005-2014
Tottori University
2014
ABSTRACT Vertebrate limb formation has been known to be initiated by a factor(s) secreted from the lateral plate mesoderm. In this report, we provide evidence that member of fibroblast growth factor (FGF) family, FGF10, emanates prospective mesoderm serve as an endogenous initiator for bud formation. Fgf10 expression in mesenchyme precedes Fgf8 nascent apical ectoderm. Ectopic application FGF10 chick embryonic flank can induce adjacent ectoderm, resulting additional complete limb. Expression...
Importance There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) RNA interference (RNAi) therapeutics in general. This study presents the longest-term to date patisiran for hATTR-PN. Objective To present adults Design, Setting, Participants global open-label extension (OLE) APOLLO randomized clinical trial phase 2 OLE enrolled patients from 43 hospitals or centers across 19 countries between July 2015 August 2017,...
We isolated the cDNA encoding a novel member of fibroblast growth factor (FGF) family from rat embryos by homology-based polymerase chain reaction. The FGF-related encodes protein 215 amino acids (∼24 kDa), which has conserved ∼120-amino acid core with ∼30-60% sequence identity FGF family. This hydrophobic terminus appears to be secreted protein. was translated in coupled vitro transcription-translation system. molecular mass translation product observed ∼26 kDa. expression mRNA embryo and...
Mouse incisors are regenerative tissues that grow continuously throughout life. The renewal of dental epithelium-producing enamel matrix and/or induction dentin formation by mesenchymal cells is performed stem reside in cervical loop the incisor apex. However, little known about mechanisms cell compartment formation. Recently, a mouse was used as model to show fibroblast growth factor (FGF) 10 regulates mitogenesis and fate decision adult cells. To further illustrate role FGF10 during tooth...
Fibroblast growth factors (FGFs) are important intercellular signaling molecules in developmental processes. Here, we show that FGF10 is secreted by cultured preadipocytes and prevention of inhibits the expression C/EBPβ subsequent differentiation these cells. An active form rescued cells which was blocked. Development white adipose tissue this knockout mice were markedly reduced, ability embryonic fibroblasts derived from to differentiate into adipocytes impaired. Therefore, plays an role...
We isolated the cDNA encoding a novel member of human fibroblast growth factor (FGF) family from lung. The encodes protein 208 amino acids with high sequence homology (95.6%) to rat FGF-10, indicating that is FGF-10. Human FGF-10 as well has hydrophobic terminus ( approximately 40 acids), which may serve signal sequence. apparent evolutionary relationships FGFs indicate closest FGF-7. Chromosomal localization gene was examined by in situ hybridization. found map 5p12-p13 region. (amino...
In rat embryos, fibroblast growth factor (FGF)-16 is predominantly expressed in brown adipose tissue. To elucidate the role of FGF-16, we examined expression FGF-16mRNA embryonic tissue at different developmental stages by Northern blotting analysis and situ hybridization. FGF-16 mRNA was abundantly during day 17.5, days 17.5–19.5, thereafter lower levels into neonatal period. The profile well corresponds to proliferative reported. We also mitogenic activity recombinant for primary...
Recent studies demonstrating a close relationship between postprandial hyperglycemia and the incidence of atherosclerotic cardiovascular disease prompted us to investigate generation source reactive oxygen species (ROS) in endothelial cells stimulated by short-term exposure high glucose concentration. In addition, we investigated effect insulin on ROS production induced Cultured bovine aortic demonstrated significant increase intracellular after 3-h 25 mM (131.4% versus 5 glucose). This...
Background Recent investigations suggest that activation of coagulation and fibrinolysis occurs in patients with ulcerative colitis (UC). However, the role hypercoagulable state UC has not been determined. On other hand, there are no reports dealing ischemic (IC), which acute bowel inflammation reversible vascular occlusion affect colon. Thus, our aim was to evaluate hyper states by comparing activations active those IC. Methods Twenty-four 12 IC were studied, 18 inactive serving as...
Background A strong correlation between left atrial ( LA ) dysfunction and the severity of cardiac disease has been described in human patients with various diseases. The role dogs chronic mitral valvular heart CMVHD not addressed. Objectives To investigate function prognosis . Animals Thirty‐eight client‐owned Methods Prospective clinical cohort study. Dogs were divided into 2 groups (survivors nonsurvivors) based on onset cardiac‐related death within 1 year. Physical examination...
Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment malaria on Java Island, Indonesia, were screened their antibabesial and antimalarial activities. Among extracts, 8 displayed strong activity, with an inhibition range 89.6 to 100%, 15 showed 84.2 98.1%. The Achillea millefolium, Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida Swietenia macrophylla both activities paralleled activities, but converse was not true.
Bioassay-guided fractionation of boiled aqueous extracts from the whole plant Phyllanthus niruri led to isolation 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values 4.7 microg/mL against Babesia gibsoni and 1.4 Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, gallic acid were also isolated. Structures these elucidated on basis their chemical spectroscopic data.
Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro. Of these extracts, the fruit of Brucea javanica was most active inhibiting parasite growth at a concentration 10 µg/mL. Bioassay-guided fractionation extract Br. led to isolation two new quassinoids, bruceantinol B and bruceine J, structures compounds elucidated on basis spectroscopic data by chemical transformation known compounds. In addition,...
Two middle-aged patients with motor neuron disease showed common eye movement disorders and intellectual impairment in the later stage of illness. Eye were characterized by slow saccades vertical glaze palsy, which seemed to be supranuclear ophthalmoplegia. Neuropathological examination one patient revealed degeneration substantia nigra without pathological changes ocular nuclei, addition findings compatible disease. These cases appear raise a possibility distinct group multiple system degenerations.
We attempted to develop a strain of Babesia gibsoni resistant diminazene aceturate (DA), an anti-babesial drug, in vitro. Since the DA-sensitive B. could survive and proliferate culture medium containing 1 ng/m l DA, concentration DA was gradually increased from 200 ng/ml. The results showed that parasites which much higher than 50% inhibitory (IC50) for gibsoni. Subsequently, these were removed erythrocytes exposed directly ng/ml DA. They able invade fresh erythrocytes, though did not...