A5017858870- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Polymer Surface Interaction Studies
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Corrosion Behavior and Inhibition
- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Molecular Junctions and Nanostructures
- Hormonal Regulation and Hypertension
- Renal cell carcinoma treatment
- Dermatology and Skin Diseases
- Diet, Metabolism, and Disease
- Oral and gingival health research
- Adipokines, Inflammation, and Metabolic Diseases
Tokyo Women's Medical University
2015-2024
Kanazawa University
2008-2024
Mitsui (Japan)
2023
The Japanese Society of Gastroenterological Surgery
2022
National Institute of Technology, Kumamoto College
2022
National Institute of Technology, Kagoshima College
2022
SACHEM (United States)
2022
Aarhus University
2013-2021
Tokyo Women's Medical University Hospital
2021
University of Toyama
2006-2019
Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic that often invasive and metastatic, resulting in poor prognosis. Few molecular alterations unique to IPMN are known. We performed whole-exome sequencing for primary tissue, which uncovered somatic mutations KCNF1, DYNC1H1, PGCP, STAB1, PTPRM, PRPF8, RNASE3, SPHKAP, MLXIPL, VPS13C, PRCC, GNAS, KRAS, RBM10, RNF43, DOCK2 CENPF. further analyzed GNAS archival cases of 118 IPMNs 32 ductal adenocarcinomas (PDAs), revealed...
This work demonstrates the feasibility of superhydrophilic polyelectrolyte brush coatings for anti-icing applications. Five different types ionic and nonionic polymer 25-100 nm thickness were formed on glass substrates using silane chemistry surface premodification followed by polymerization via SI-ATRP route. The cationic [2-(methacryloyloxy)ethyl]trimethylammonium chloride] anionic [poly(3-sulfopropyl methacrylate), poly(sodium methacrylate)] brushes further exchanged with H+, Li+, Na+,...
Objectives Clinical Practice Guidelines for Pancreatic Cancer based on Evidence-Based Medicine 2006 were first published by the Japan Pancreas Society, and they revised to 2009 in July further 2013 October 2013. These guidelines established according evidence-based medicine. In 2016, newly Japanese. Methods version, we introduced concepts of GRADE - grading recommendations assessment, development, evaluation approach better understanding current guidelines. Results The show algorithms...
Abstract Acinar cell carcinoma of the pancreas is a rare tumor with poor prognosis. Compared to pancreatic ductal adenocarcinoma, its molecular features are poorly known. We studied total 11 acinar carcinomas, including 3 by exome and 4 target sequencing. Exome sequencing revealed 65 nonsynonymous mutations 22 indels mutation rate 3.4 mutations/Mb per tumor, on average. By accounting for not only somatic but also germline loss wild-type allele, we identified recurrent BRCA2 FAT genes. showed...
We aimed to identify molecular biomarkers for assessing the progression of intraductal papillary mucinous neoplasm pancreas (IPMN).We retrospectively investigated aberrations and their associations with clinicopathological features in 172 IPMNs.GNAS KRAS mutations were detected 48% 56% IPMNs, respectively. No EGFR, PIK3CA GNAO1, GNAQ, or GNAI2 observed. Significant observed between IPMN morphological types GNAS mutations, expression phosphorylated MAPK (pMAPK), AKT, AKT (pAKT), nuclear...
Clinicopathologic and genetic features of familial pancreatic cancer (FPC) in Asian countries remain largely unknown. The main purpose this study was to determine the prevalence FPC define causative FPC-predisposition genes a Japanese cohort with ductal adenocarcinoma (PDAC).We reviewed 1,197 patients pathologically proven PDAC found that 88 (7.3%) were who had at least one first-degree relative PDAC. There no significant differences between cases sporadic terms gender, age, tumor location,...
Mutations in RNF43, which encodes the ubiquitin E3 ligase ring finger protein 43, were recently found intraductal papillary mucinous neoplasms of pancreas. We evaluated somatic mutations RNF43 and expression 43 as well their associations with molecular clinicopathological features 176 surgically resected neoplasms. Frozen tissues available for 57 cases used next-generation sequencing analysis entire coding exons RNF43. Formalin-fixed paraffin-embedded from all immunohistochemical 43....
Abstract Time of flight secondary ion mass spectrometry (ToF‐SIMS) and X‐ray photoelectron spectroscopy (XPS) have been employed to study the interfacial interaction between polymeric methylene diphenyl diisocyanate (PMDI) aluminum produced by deposition a thin PMDI layer on aluminum, in order improve adhesion and/or abhesion performance. When concentration increases, intensity ratio fragments indicative reaction product with water (m/z = 106 u: C 7 H 8 N + ) that isocyanate group 132 6 NO...
Intraductal tubulopapillary neoplasms (ITPNs) are composed of glands with high-grade dysplasia in the pancreatic duct. papillary mucinous gastric type, pyloric gland variant (IPMN-PGs) tubular mimicking low-grade and were formerly called intraductal adenomas. Because their apparent common morphology, IPMN-PGs ITPNs could be associated. While former might progress to latter, this has not been fully assessed. In study, we compared molecular features determine association using formalin-fixed,...
Novel types of dual-functional surface-attached polymer brushes were developed by post-polymerization modification poly(glycidyl methacrylate) on glassy carbon substrates. Azide and alcohol groups initially introduced epoxide ring-openings the side chains. These represent an attractive chemical platform to deliberately introduce other molecular units at specific sites. In this work, ferrocene nitrobenzene redox immobilized through two create polymers. In-depth analysis infrared...
S100A4 has been implicated in invasion and metastasis of cancer, but prognostic significance its expression esophageal squamous cell carcinoma remains unclear. In this study, we examined the by Western blot analysis immunohistochemistry surgically resected carcinoma. The relationship between tissue status clinicopathological findings was analyzed to assess protein level significantly higher tumor than corresponding normal mucosa (p<0.05) 22 cases analysis. detected 25% 52 correlated with...
Clinical practice guidelines for pancreatic cancer based on evidence-based medicine (2006) were published by the Japan Pancreas Society (Committee revision of clinical cancer) in March 2009 Japanese, revised to Practice Guidelines Pancreatic Cancer (2009) July Japanese and further (2013) October 2013 Japanese. These established according medicine. A total 629 papers collected from among 4612 reports concerning listed PubMed Igakuchuo Zasshi between May 2007 January 2011. This new set was...
Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of receptor caveolae microdomains (lipid rafts), which is essential for execution complete metabolic adipocytes. Macrophage-secreted factors including proinflammatory cytokines, tumor necrosis factor-α and interleukin-1β, adipose tissues have limit local adipogenesis induce resistance; however, interplay between adipocytes macrophages upon regulation expression not...
Recent studies suggest a relationship between intestinal microbiota and metabolic syndromes; however, the underlying mechanism remains unclear. To clarify this issue, we assessed effects of bacterial cell wall components on adiponectin, leptin resistin secretion from rat visceral adipocytes in vitro. We also measured relative population Firmicutes Bacteroidetes fecal amount mucin as an barrier function, when mice were fed high-fat diet. In present study, demonstrated that affect adipokines,...
Chemoradiotherapy is a treatment option for locally advanced pancreatic cancer. However, the efficacy of induction chemotherapy prior to chemoradiotherapy uncertain. The aim this randomized, multicentre phase II study evaluate and safety with without determine significance chemotherapy.Patients cancer were randomly assigned arm (Arm A) or followed by B). Patients in Arm A underwent radiotherapy concurrent S-1. B received gemcitabine 12 weeks, thereafter, only patients controlled disease same...
In this work, various lengths and densities of poly(methyl methacrylate) (PMMA) brushes were synthesized on stainless steel (SS) surfaces via surface initiated atom transfer radical polymerization. Subsequently, the joints between bulk PMMA brushed obtained by injection molding, for these degree adhesion was assessed tensile testing. Several conditions are required to facilitate mixing polymer reduce residual stress at interface: preheating SS samples before molding; a long packing time;...