A5082904583- Food composition and properties
- Gut microbiota and health
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Digestive system and related health
- Oral health in cancer treatment
- Animal Nutrition and Physiology
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Infectious Aortic and Vascular Conditions
- Nutritional Studies and Diet
- Abdominal vascular conditions and treatments
- Inflammatory Bowel Disease
- Microbial Metabolites in Food Biotechnology
- Diabetes and associated disorders
- Phytase and its Applications
- Escherichia coli research studies
- Helicobacter pylori-related gastroenterology studies
- Electrospun Nanofibers in Biomedical Applications
- Hematopoietic Stem Cell Transplantation
- Ion channel regulation and function
- Cancer-related Molecular Pathways
- Ruminant Nutrition and Digestive Physiology
- Biliary and Gastrointestinal Fistulas
- Tissue Engineering and Regenerative Medicine
CSIRO Health and Biosecurity
2011-2023
Commonwealth Scientific and Industrial Research Organisation
2006-2020
Animal, Food and Health Sciences
2010-2020
St James's University Hospital
2020
Health Sciences and Nutrition
2007-2017
Women's & Children's Health Research Institute
1999-2006
The University of Adelaide
2006
University of North Carolina at Chapel Hill
2005
Cooperative Research Centre for Tissue Growth and Repair
2002
Women's and Children's Hospital
1999-2002
Abstract Background Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in gut microbiome have been implicated development NAFLD/NASH, although underlying mechanisms remain unclear. Results We found that consumption prebiotic inulin markedly ameliorated phenotype including steatosis fibrosis, mice. Inulin resulted global changes microbiome, concomitant enrichment genera Bacteroides...
BackgroundRheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed RA patients. For instance, new-onset untreated (NORA) associated underrepresentation Clostridium cluster XIVa, including Lachnospiraceae, which are major butyrate producers, although pathological relevance remained obscure. Follicular regulatory T (TFR) cells play critical roles pathogenesis...
Colorectal cancer (CRC) is a major cause of death worldwide. Studies suggest that dietary fibre offers protection perhaps by increasing colonic fermentative production butyrate. This study examined the importance butyrate investigating effects resistant starch (RS) and butyrylated-RS on azoxymethane (AOM)-induced CRC in rats. Four groups (n = 30 per group) Sprague-Dawley rats were fed AIN-93G-based diets containing standard low-RS maize (LAMS), LAMS + 3% tributyrin (LAMST), 10% high-amylose...
Animal studies show that increasing large bowel butyrate concentration through ingestion of butyrylated or resistant starches opposes carcinogen-induced tumorigenesis, which is consistent with population data linking greater fiber consumption lowered colorectal cancer (CRC) risk. Butyrate has been shown to regulate the apoptotic response DNA damage. This study examined impact by dietary starch on colonic epithelium rats treated genotoxic carcinogen azoxymethane (AOM). Four groups 10 male...
Isogenic mutants of Streptococcus gordonii DL1 (Challis) in which the genes encoding high-molecular-mass cell surface polypeptides CshA and/or CshB were inactivated deficient binding to four strains Actinomyces naeslundii and two oralis. Lactose-sensitive interactions S. with A. ATCC 12104 PK606 associated expression cshA but not cshB. Lactose-insensitive T14V WVU627, oralis C104 34, dependent on cells bound immobilized human fibronectin (Fn), soluble Fn, a dose-dependent manner, was...
The experience of Middlesex Hospital in the investigation and management chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO these critically evaluated terms insorptive exsorptive function. No relation was between performance degree potential ischaemia suggested by angiography. Twenty two underwent reconstruction coeliac axis mesenteric arteries, with three perioperative deaths. remainder followed for...
During gastrointestinal infection, dysbiosis can result in decreased production of microbially derived short-chain fatty acids (SCFAs). In response to the presence intestinal pathogens, we examined whether an engineered acetate- or butyrate-releasing diet rectify deficiency SCFAs and lead resolution enteric infection.We tested a high butyrate-producing (HAMSA HAMSB, respectively) condition Citrobacterrodentium infection mice assess its impact on host-microbiota interactions. We analysed...
Adult male pigs were fed on a diet containing (% of energy) fat 25 starch 55 from white rice and providing 20 g fibre/pig d (diet WR). In two other groups bran was added to the provide 43 fibre/d. One group received unmodified RB), but in another RO) heat-stabilized unrefined oil replaced palm oil. further brown provided 37 per BR). Plasma cholesterol concentrations similar with diets WR, RB BR. With RO concentration significantly lower than WR BR not different RB....
Non-abraded rabbit endothelium has been exposed to human blood taken from male non-smoking volunteers before and after the smoking of two medium tar cigarettes, in an vitro system using a Baumgartner chamber. In each case was allowed circulate for 10 min at constant flow rate. Blood tested this way. Scanning electron microscopy endothelial surfaces demonstrates large numbers adherent platelets when 'post-smoking blood' is used, but very few some cases none with 'pre-smoking' blood. As...
Large-bowel fermentation of resistant starch produces SCFA that are believed to be important in maintaining visceral function. High-amylose maize (HAMS) and acylated starches sources an effective means increasing colonic SCFA. Cooking increases digestibility but its effects on the capacity these raise large-bowel unknown. We have examined cooking HAMS butyrylated (HAMSB) amylolysis vitro their caeco-colonic rats. The were boiled excess water microwaved, followed by drying at 100 degrees C....
A preliminary laboratory study has been undertaken using dogs, in which porous Dacron arterial prostheses have seeded with autologous peritoneal mesothelial cells before implantation into the system. These were harvested from omentum by collagenase digestion and introduced graft at time of preclotting. Examination grafts scanning transmission electron microscopy one month after insertion showed no organized cellular lining control graft. In three there was a extended over whole surface up to...
Dietary resistant starch (RS), as a high amylose maize (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing availability may improve colonic health and butyrylated (HAMSB) is an effective method of achieving this goal. In study, rats ( n = 8 per group) were fed diets containing levels (25%) protein casein with 10 or 20% HAMSB HAMS. Colonocyte was...
Non-starch polysaccharides (NSP; major components of dietary fibre) have been rather disappointing in the prevention and management large bowel inflammatory diseases (IBD) or colorectal cancer (CRC). Resistant starch (RS) is that which escapes small intestinal digestion enters bowel. RS contributes to total fibre could be as important NSP promoting health preventing IBD CRC. Indeed, it appears some societies historically at low risk for these conditions eat relatively little but diets high...