A5102779164- Hair Growth and Disorders
- Semiconductor Quantum Structures and Devices
- Insects and Parasite Interactions
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Insect and Arachnid Ecology and Behavior
- Glycosylation and Glycoproteins Research
- melanin and skin pigmentation
- Photonic and Optical Devices
- Gut microbiota and health
- Quantum Dots Synthesis And Properties
- Insect Pest Control Strategies
- Advanced Semiconductor Detectors and Materials
- Mosquito-borne diseases and control
- Diabetes and associated disorders
- Semiconductor Lasers and Optical Devices
- Genomics and Phylogenetic Studies
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Insect and Pesticide Research
- Signaling Pathways in Disease
- Enzyme Production and Characterization
- Dermatologic Treatments and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
Chiba University
2025
Chiba University Hospital
2024
Hashimoto Municipal Hospital
2023
Kin-ikyo Chuo Hospital
2021-2022
Tokyo Institute of Technology
2013-2021
Miyagi Advanced Dental Hygienist College
2020
Nippon Veterinary and Life Science University
2008-2020
Fuji Electric (Japan)
2001-2019
Kao Corporation (Japan)
2018
The University of Tokyo
2018
Abstract Faecal lipopolysaccharides (LPS) have attracted attention as potent elements to explain a correlation between the gut microbiota and cardiovascular disease (CVD) progression. However, underlying mechanism of how specific bacteria contribute faecal LPS levels remains unclear. We retrospectively analysed data 92 patients found that abundance genus Bacteroides was significantly negatively correlated with levels. The controls showed higher than in CVD. endotoxin units LPS, determined by...
Lung surfactant is a complex mixture of lipids and proteins, which secreted from the alveolar type II epithelial cell coats surface alveoli as thin layer. It plays crucial role in prevention collapse through its ability to reduce tension. Under normal conditions, homeostasis maintained by balancing release uptake for recycling internalization macrophages degradation. Little known about how pool monitored regulated. Here we show, an analysis gene-targeted mice exhibiting massive accumulation...
Aims: Circulating amino acid (AA) abnormalities serve as predictors of adverse outcomes in patients with heart failure (HF). However, the role gut microbiota AA disturbances remains unknown. Thus, we investigated microbial functions and their associations metabolic alterations HF. Methods Results: We performed whole-genome shotgun sequencing fecal samples mass spectrometry-based profiling AAs compensated Plasma levels total essential (EAAs) histidine were significantly lower HF than control...
Cancer cachexia, which is characterized by weight loss and muscle weakness, common in patients with pancreatic cancer. Anamorelin, a ghrelin receptor agonist, has shown potential for the management of cachexia various cancers. We herein report 64-year-old man unresectable cancer who experienced significant gain anamorelin, allowing continued chemotherapy an improved quality life. Despite disease progression, his response suggests utility anamorelin as supportive therapy. Cachexia's complex...
Apilactobacillus kosoi ( A. ) 10H is a fructophilic lactic acid bacterium found in vegetable sugar fermentation liquid. It has been shown to possess high intestinal immunostimulatory activity. In this study, we investigated the potential for heat‐killed cells and their components convert phenotype of immunosuppressive M2 macrophages M1 macrophages. We further ability induction apoptosis cancer cell lines by macrophage culture medium presence cells. After differentiation phorbol 12‐myristate...
For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds plant extracts concerning growth-promoting activity with respect to follicle cells. After an extensive search, discovered that proanthocyanidins extracted from grape seeds promote proliferation cells isolated mice by 230% relative controls (100%); and remarkable hair-cycle-converting telogen phase anagen in C3H vivo test systems. The profile active fraction was elucidated...
The Culex pipiens complex consists of vector mosquitoes that transmit important human pathogens. In this study we established a simplified method to distinguish three members the Cx. complex, p. pallens Coquillet, form molestus Forskal, and quinquefasciatus Say, collected in Japan. Sequence analysis Drosophila Ace-orthologous acetylcholinesterase (Ace) gene (668 680 bp) revealed single polymorphic region characterizes each species. Based on region, specific primers (ACEpip2) (ACEpall2) were...
Sappanwood (Caesalpinia sappan Linn.) is used as an herbal medicine. It sometimes to treat skin damage or a facial cleanser. In the present study, methanol (MeOH) extract of sappanwood was found inhibit melanin synthesis in cultured human melanoma HMV-II cells stimulated with forskolin, and six active compounds (1-5 7) were isolated from along non-active compound (6). Compounds 2-7 identified sappanchalcone (2), 3'-deoxy-4-O-methylsappanol (3), brazilein, (4), brazilin (5), sappanol (6),...
Neuroinflammation plays a central role in the pathophysiology of Alzheimer’s disease (AD). Compounds that suppress neuroinflammation have been identified as potential therapeutic targets for AD. Rhinacanthin C (RC), naphthoquinone ester found Rhinacanthus nasutus Kurz (Acanthaceae), is currently proposed an effective molecule against inflammation. However, exact RC on remains to be elucidated. In present study, we investigated effect modulating lipopolysaccharides (LPS), amyloid‐ β peptide...
Lactic acid bacterium-containing fermentates provide beneficial health effects by regulating the immune response. A naturally fermented vegetable beverage, a traditional Japanese food, reportedly provides benefits; however, function of its bacteria has not been clarified. Apilactobacillus kosoi is predominant lactic bacterium in beverage. Using murine Peyer's patch cells, we compared immunoglobulin (IgA)-inducing activity A. 10HT to those 29 other species and found that belonging genus (A....
Alpha1,6-fucosyltransferase catalyzes the transfer of fucose to innermost GlcNAc residue an N-linked oligosaccharide. In order identify amino acid residue(s) which are associated with enzyme activity and investigate their function, we prepared a series mutant human alpha1,6-fucosyltransferases in conserved residues region homologous alpha1,2-fucosyltransferase had been replaced. These proteins were then characterized by kinetic analyses. The wild-type expressed using baculovirus-insect cell...
We have previously reported that several selective protein kinase C (PKC) inhibitors, including procyanidin B-2, promote hair epithelial cell growth and stimulate anagen induction.We discuss the hypothesis hair-growing activity of B-2 is related to its downregulation or inhibition translocation PKC isozymes in cells.We examined effect on expression cultured murine cells as well isozyme localization dorsal skin at different stages cycle.We observed reduces PKC-alpha, -betaI, -betaII -eta also...
Catechins, biologically active polyphenols in green tea, exhibit various biological activities, such as anticancer and antiviral arising from interactions with functional proteins. However, the molecular details of these remain unclear. In this study, we investigated between human serum albumin (HSA) catechins, including some a galloyl group, by means isothermal titration calorimetry (ITC), differential scanning (DSC), docking simulations. Our results indicate that group was important for...