A5101917160- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Iron Metabolism and Disorders
- Diabetes Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
- Speech and Audio Processing
- SARS-CoV-2 and COVID-19 Research
- Renal and Vascular Pathologies
- Hepatitis C virus research
- Folate and B Vitamins Research
- Liver Disease and Transplantation
- Dermatological and Skeletal Disorders
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Muscle metabolism and nutrition
- Erythropoietin and Anemia Treatment
- Blind Source Separation Techniques
- Complement system in diseases
- COVID-19 Clinical Research Studies
Musashino Red Cross Hospital
2025
Japanese Society for Dialysis Therapy
2021
Fujita Health University Hospital
2002-2016
Nara Institute of Science and Technology
2014
Memorial Hospital of South Bend
2000-2004
Niigata University
2000-2003
University of Fukui
1985-2000
Institute of Clinical Research
1986
Kanazawa University Hospital
1986
Hokuriku University
1986
Abstract The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4458 dialysis facilities at end 2018; among these facilities, 4402 (98.7%) responded facility questionnaire, and 4222 (94.7%) patient questionnaire. number chronic patients in Japan continues increase every year; as 2018, it had reached 339,841 patients, representing 2688 per million population. Among prevalent mean age 68.75 years, diabetic nephropathy most common primary disease...
Abstract Background The 2020 Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) annual survey was sent to 4493 dialysis facilities in Japan. Methods Questionnaires were all that provide patients with therapy collected and compiled form cross-sectional results of renal replacement from various aspects. Results In total, 4437 (98.8%) responded the facility questionnaire 4271 (95.1%) patient questionnaire. number chronic Japan continues increase every year, reaching 347,671 at end...
Abstract The prevalence of anti‐hepatitis C virus (HCV)antibodies is higher in hemodialysis patients than the general population, and several studies have reported poor vital prognosis HCV‐infected dialysis because infection with HCV not only cause cirrhosis hepatocellular carcinoma, but also a risk factor for cardiovascular disease. Although sustained virologic response (SVR) achievable interferon ribavirin patients, SVR rates are lower, use challenging hemolytic anemia. Recently,...
Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD), and as the progresses SHPT associated with systemic consequences, termed CKD-mineral bone disorder. Currently, cinacalcet indicated for treatment SHPT; however, upper gastrointestinal adverse events. Evocalcet has been developed to address these issues, but long-term safety efficacy evocalcet need be evaluated. To more accurately reflect clinical practice, this phase 3, multicenter, open-label...
Abstract. Hyperhomocysteinemia, which results from renal impairment, may promote arteriosclerosis and glomerulosclerosis. The combined effect of failure a common mutation (C677T) in the methylenetetrahydrofolate reductase gene that leads to serum homocysteine elevations dialysis patients was investigated. Genotypes were determined at this locus 545 676 healthy subjects, concentrations total folate measured subgroup 464 patients. Multiple regression analysis showed TT genotype low...
Abstract: We investigated the clinical efficacy of direct hemoperfusion with a β 2 ‐microglobulin (β ‐m) adsorption column for treatment patients dialysis‐related amyloidosis. A 2‐year prospective controlled study was performed to compare effects passaging blood through (Lixelle) before it is passaged dialysis polysulfone membrane on severity amyloidosis in these individuals. Patients ( n = 22) whose went Lixelle prior had higher ‐m removal rate compared an equal number controls, and they...
Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to exert cardiorenal protective effects in diabetic patients and are widely used clinically. In addition, an increasing number of reports now suggest these drugs may even be beneficial non-diabetic patients. However, SGLT2 rarely prescribed for kidney transplant recipients due the risk renal graft damage urogenital infections. Case presentation We report cases 5 with chronic disease G3a-4 metabolic syndrome...
Crystalline light chain inclusion-associated kidney disease affects mainly tubular epithelial cells and is often clinically manifested as Fanconi syndrome. However, only very few case reports about the crystalline deposits within podocytes are available, nature of pathogenic monoclonal implicated in these cases still unknown. We report a podocytopathy which we identified complete structure belonging to germ-line gene Vκ1-39.We describe 65-year-old woman with showing mild proteinuria renal...
Abstract Background Hemodialysis patients are more likely to be severely affected if infected by COVID-19. Contributing factors include chronic kidney disease, old age, hypertension, type 2 diabetes, heart and cerebrovascular disease. Therefore, action against COVID-19 for hemodialysis is an urgent issue. Vaccines effective in preventing COVID 19 infection. In patients, however, responses hepatitis B influenza vaccines reportedly weak. The BNT162b2 vaccine has shown efficacy rate of about...
Abstract Background Renal transplant recipients with chronic kidney disease often develop post-transplant diabetes mellitus or metabolic syndrome (MetS), which are poor prognostic factors after renal grafts. Although recent studies have reported the protective effects of glucagon-like peptide-1 receptor agonist (GLP-1RA) on heart and kidneys, few assessed its in patients. Moreover, to our knowledge there been no oral GLP-1RA (semaglutide) transplantation Japan. Case presentation 1 was a...
In this paper, we provide a theoretical analysis of the minimum mean-square error short-time spectral amplitude (MMSE-STSA) estimator with biased priori SNR estimation and its extension to musical-noise-free speech enhancement. Recently, enhancement has been proposed, where no musical noise is generated in iterative subtraction. However, existence condition MMSE-STSA reported. Therefore, show that exists via analysis. addition, perform comparative experiments clarify efficacy proposed
Abstract. Among patients undergoing maintenance hemodialysis, a decreased high-density lipoprotein cholesterol (HDL-C) concentration is among the most common abnormalities of lipid metabolism and apparently an independent risk factor for vascular disease. A missense mutation cholesteryl ester transfer protein gene, D442G (Asp 442 to Gly), increases HDL-C levels through reduced activity from HDL VLDL, but also may lead reverse transport. To investigate effect polymorphism on atherosclerotic...
遺伝子組換えヒトエリスロポエチン製剤 (rHuEPO) が6か月以上継続投与されている慢性維持血液透析患者 (血液透析導入後6か月以上経過例) 2,654例を対象に, 維持Ht値と生命予後との関係をretrospectiveに調査, 検討した. Cox回帰分析による1年死亡リスクは, 平均Ht値27%以上30%未満の群を対照 [Relative Risk (RR): 1.000] とした場合にHt 30%以上33%未満の群でRR: 0.447 [95%信頼区間 (95% CI): 0.290-0.689 p=0.0003] と有意に良好であったが, Ht 33%以上36%未満の群ではRR: 0.605 [95% CI: 0.320-1.146 p=0.1231] と有意差を認めなかった. 一方, 27%未満の群ではRR: 1.657 1.161-2.367 p=0.0054] と有意に予後不良であった. また, 3年死亡リスクも1年死亡リスクと同様, 30%以上33%未満の群ではRR: 0.677 0.537-0.855 p=0.0010] 1.111 0.816-1.514...
Abstract According to the annual survey of Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) conducted at end 2018, there were a total 339,841 patients receiving dialysis (hereinafter, patients) in Japan. The included questions regarding presence/absence dementia, performance status (PS), and exercise habits individual patients. revealed that 10.8% all had dementia (1.8% age group less than 65 years, 6.8% 65–74 22.7% 75 years or older). These prevalences approximately equal...
Abstract Background Renal transplant recipients with chronic kidney disease (CKD) often develop abnormal glucose metabolism. Although recent studies have reported the protective effects of sodium-glucose transport protein 2 (SGLT2) inhibitors on heart and kidneys, few assessed their effect in renal patients. Moreover, to our knowledge, there been no SGLT2 Japan. Case presentation 1 was a 67-year-old male recipient post-transplant diabetes mellitus. He administered empagliflozin 10 mg once...
IgG4関連疾患(IgG4-RD)は潜在性に腎不全を引き起こす.血液透析患者における高IgG4血症,IgG4-RDの頻度を調査することを目的に,対象者227例において血清IgG4値を測定し,平均血清IgG4値が34 mg/dL(範囲3~329)で2.2%にIgG4≥135 mg/dL,5.3%にIgG4≥105 mg/dL(基準値上限)を認めた.年齢,性別,生活習慣,悪性腫瘍などの既往・併存症,各血液検査値について,線型回帰分析により血清IgG4値との関連を探索したところ,男性,低CH50血症,総Cho低値,抗核抗体陽性,非高血圧,喫煙歴が関連していた.高値例12例に対して診療録を精査し,IgG4-RDによる腎不全症例1例を認めた.透析患者における高IgG4血症は男性,喫煙,免疫異常を示唆する所見などと関連し,高値例の一部に潜在性患者も存在する.腎不全の原因としてIgG4-RDも考慮する必要がある.
Lipid metabolism and adiponectin modulate erythropoiesis in vitro general population studies may also affect responsiveness to erythropoietin patients undergoing haemodialysis (HD). However, little is known about the impact of lipid-associated biomarkers on reticulocyte production resistance index (ERI) HD. Therefore, we aimed investigate their impacts 167 stable
Abstract Background With the widespread use of vaccine and predominance Omicron strain, number patients presenting with typical coronavirus-infection disease 2019 (COVID-19) pneumonia on computed tomography (CT) has decreased dramatically. This also been true for hemodialysis patients. Case report A 72-year-old female maintenance patient hypogammaglobulinemia was diagnosed COVID-19 based a nasopharyngeal swab severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) polymerase chain...
Abstract The annual survey of the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry (JRDR) at end 2021 was conducted 4508 facilities, which 4454 facilities (98.8%) returned facility questionnaire and 4251 (94.3%) patient questionnaire, giving response rates as high those in previous years. number dialysis patients Japan has been increasing year by year, reaching 349,700 or 2786 per million population according to results survey. mean age based on 69.67 years, with most common...