A5072013505- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Abdominal vascular conditions and treatments
- Salivary Gland Disorders and Functions
- Vascular Malformations and Hemangiomas
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Pediatric Urology and Nephrology Studies
- Soft tissue tumor case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Kawasaki Disease and Coronary Complications
- Erythropoietin and Anemia Treatment
- Sarcoidosis and Beryllium Toxicity Research
Kanazawa University
2016-2025
Kanazawa University Hospital
2016-2025
Public Central Hospital of Matto Ishikawa
2024
Aix-Marseille Université
2024
Kanazawa Medical University
2024
Centre d’Immunologie de Marseille-Luminy
2024
Takara (Japan)
2021
Ishikawa Prefectural Central Hospital
2011-2020
keiyu Hospital
2020
Kanazawa Municipal Hospital
2017
Recent studies have clarified that endogenous cannabinoids (endocannabinoids) are released from depolarized postsynaptic neurons in a Ca 2+ -dependent manner and act retrogradely on presynaptic cannabinoid receptors to suppress inhibitory or excitatory neurotransmitter release. This type of modulation has been found the hippocampus cerebellum was called depolarization-induced suppression inhibition (DSI) excitation (DSE). In this study, we quantitatively examined effects depolarization...
The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted multidisciplinary physicians IgG4-RD in Japan.Various specialists retrospectively evaluated patients diagnosed between 1996 2015 five hospitals analyzing their baseline features, laboratory, imaging, pathological test findings, treatment.Of the 334 listed, 205 were male median age at diagnosis 65 years. mean number organs...
Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk rupture. study, we aimed clarify clinical course after corticosteroid therapy in periarteritis. We retrospectively evaluated features, including laboratory data, imaging findings therapy, 40 patients diagnosed with on basis periaortic/periarterial radiological findings, satisfaction...
Although tubulointerstitial nephritis with IgG4+ plasma cell (PC) infiltration is a hallmark of IgG4-related kidney disease (IgG4-RKD), only few studies are available about the minimum number PC needed for diagnosis along IgG4+/IgG+ ratio in kidney. In addition, significance deposition IgG or complement as reflection humoral immunity involvement still uncertain. this study, we analyzed 20 Japanese patients IgG4-RKD to evaluate PCs and immunity. The average was 43.8/hpf IgG4+/CD138+ 53%. C3...
IgG4-related disease is a multi-organ disorder characterized by high level of serum IgG4 and dense infiltration IgG4-positive cells into affected organs. In routine studies, however, IgG subclasses are not estimated. the present study, we attempted to clarify light-microscopic characteristics tubulointerstitial nephritis (TIN) facilitate distinction from non-IgG4-related TIN in specimens obtained renal biopsy using staining. 34 cases (13 21 non-IgG4-related), 9 nephrologists independently...
IgG4-related disease is a systemic disease, characterized by elevation of serum IgG4 and, histopathologically, massive infiltration IgG4+ lymphocyte and plasma cell infiltration, storiform fibrosis, causing enlargement, nodules or thickening. It may affect various organs simultaneously metachronously. Here we analyzed the clinical pathological characteristics 99 patients diagnosed with periaortitis/periarteritis retroperitoneal fibrosis. Of (women/men, 15/84; mean age 67.3±9.5 years), 33...
Abstract Background Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a CLAM-LC-MS/MS system, which consists of sample preparation module directly connected LC-MS/MS, could be used for clinical TDM work immunosuppressive drugs in whole blood, requires hemolytic process. For purpose, prospectively validated system...
TAFRO syndrome is a systemic inflammatory disorder of unknown etiology, and its diagnosis requires the exclusion autoimmune diseases. A 42-year-old Japanese woman presented with syndrome-like manifestations, but had undiagnosed limited-cutaneous sclerosis preventing definitive syndrome. However, her clinical course pathological findings, including renal glomerular microangiopathy, were consistent We performed systematic review literature to evaluate how autoimmunity affects characteristics...
To clarify the clinicoepidemiological characteristics of immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with malignancy, a nationwide epidemiological survey was conducted.Immunoglobulin G4-related patients malignancy who had visited selected hospitals in Japan were surveyed. The study consisted two stages: number IgG4-RD estimated by first questionnaire and their assessed second questionnaire.The frequencies autoimmune pancreatitis (AIP), IgG4-related sialadenitis, eye disease, kidney...
Objectives This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN). Methods We studied six IgG4-related TIN patients receiving renal biopsies before and after therapy. Their clinical data histological findings were evaluated Results Elevated serum creatinine levels rapidly improved except for two patients, whom it persisted. Abnormal radiological all although focal cortical atrophy...
Objectives This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN).
Multicentric Castleman disease is a benign lymphoproliferative disorder with heterogenous clinical symptoms and involves systemic organs in addition to lymph nodes. Elevated serum IgG4 levels IgG4-positive plasma cell (IgG4+PC) infiltrates have been reported nodes, lung skin some multicentric cases, resembling IgG4-related (IgG4-RD) histologically. However, no report has available regarding IgG4+PC infiltration the kidneys of disease. Here, we 2 cases complicated by there published on...
In immunoglobulin G4-related kidney disease (IgG4-RKD), focal or diffuse renal cortical atrophy is often observed in the clinical course after glucocorticoid therapy. This study aimed to clarify factors related therapy IgG4-RKD.We retrospectively evaluated features including laboratory data and computed tomography (CT) findings before 23 patients diagnosed with IgG4-RKD, all of whom were followed up for more than 24 months.Seventeen men, six women (average age 62.0 years). Average follow-up...
We report a case of Henoch- Schönlein purpura nephritis (HSPN) associated with tubulointerstitial (TIN) and chronic sclerosing sialoadenitis. The patient is 75-year-old Japanese woman who had bilateral submandibular gland swelling, palpable on the lower legs, decreased renal function hematoproteinuria marked hypocomplementemia, but no skin lesion suggestive systemic lupus erythematosus (SLE), did not fulfill classification criteria for SLE. Her serum IgG4 level was high immunostaining...
This study aimed to investigate the contribution of a proliferation-inducing ligand (APRIL), member tumor necrosis factor (TNF) superfamily implicated in plasma cell survival, development cell-rich lesions immunoglobulin G4-related disease (IgG4-RD).We performed immunohistochemical staining for APRIL with Stalk-1 and Aprily-8 antibodies specifically recognizing APRIL-producing cells secreted APRIL, respectively, renal submandibular IgG4-RD comparison those Sjögren's syndrome...
Immunoglobulin G4 (IgG4)-related tubulointerstitial nephritis (TIN) is often accompanied by autoimmune pancreatitis (AIP) or chronic sclerosing dacryoadenitis and sialoadenitis. However, IgG4-related TIN without AIP lacrimal and/or salivary gland lesions has not been well recognized. Here, we report a case of associated with hepatic inflammatory pseudotumor lesions. A 58-year-old Japanese man epigastralgia underwent contrast-enhanced computed tomography (CT), which revealed multiple...
We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) hepatitis B virus (HBV) carrier status who was successfully treated tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. administered etanercept because of the occurrence repeated flares despite aggressive therapy. C-reactive protein normalization; prednisolone dose-sparing; absence any adverse events, including HBV reactivation nucleotide analogue administration, or renal...
Adult-onset Still's disease (AOSD) usually affects young adults. Some cases of elderly-onset (EOSD) have been reported, but its clinical features are unclear. We herein report a 74-year-old woman who developed AOSD with macrophage activation syndrome (MAS). also reviewed 24 previous EOSD in patients over 70 years old and compared the findings overall AOSD. While were similar between two, including presence MAS, disseminated intravascular coagulation was more frequent than Furthermore,...