A5053649489- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Neuropeptides and Animal Physiology
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- DNA and Nucleic Acid Chemistry
- Lung Cancer Research Studies
- Pulmonary Hypertension Research and Treatments
- Protease and Inhibitor Mechanisms
- Tracheal and airway disorders
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Tuberculosis Research and Epidemiology
- Cardiac Arrhythmias and Treatments
- Folate and B Vitamins Research
- Infectious Diseases and Tuberculosis
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Synthesis and properties of polymers
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Antifungal resistance and susceptibility
Chiba University
2015-2025
Osaka Women's and Children's Hospital
2022
Kumamoto University
2015-2021
Nihon University
2021
Juntendo University
1979-2021
Chiba University Hospital
2021
University of Illinois Chicago
2018
National Hospital Organization
2007-2010
Tokyo Institute of Technology
2009-2010
National Yang Ming Chiao Tung University
2008
The static elastic properties of arterial tree (abdominal aorta and common carotid artery) were studied in 19 normal subjects 49 patients with myocardial infarction an ultrasonic phase-locked echo-tracking system that allows continuous transcutaneous measurement the diameter. stiffness index beta, which represented mechanical wall, was calculated from relation between systemic blood pressure diameter artery. Patients underwent coronary angiography their convalescent period to determine...
Acute respiratory distress syndrome (ARDS) is a severe clinical condition marked by acute failure and dysregulated inflammation. Pulmonary vascular endothelial cells (PVECs) function as an important pro-inflammatory source in ARDS, suggesting that modulation of inflammatory events at the level may have therapeutic benefit. Dipeptidyl peptidase-4 (DPP4) inhibitors, widely used for treatment diabetes mellitus, been reported to possible anti-inflammatory effects. However, potential effects DPP4...
Pulmonary hypertension (PH) with interstitial lung diseases (ILDs) often causes intractable conditions. CD26/Dipeptidyl peptidase-4 (DPP4) is expressed in constituent cells and may be related to the pathogenesis of various respiratory diseases. We aimed clarify functional roles CD26/DPP4 PH-ILD, paying particular attention vascular smooth muscle (SMCs). Dpp4 knockout (Dpp4KO) wild type (WT) mice were administered bleomycin (BLM) intraperitoneally establish a PH-ILD model. The BLM-induced...
Vascular disruption is one of the pathological hallmarks in acute respiratory distress syndrome. Bone marrow (BM)-derived circulating endothelial progenitor cells (EPCs) and lung tissue-resident EPCs have been considered to play a pivotal role pulmonary vascular repair; however, which population predominant local vasculogenesis remains be clarified. We therefore examined origin participating regenerative process (PVECs) experimental Lung samples from mice administered LPS intratracheally...
Abstract Mycobacterium goodii , a rapidly growing non‐tuberculous mycobacterium, rarely causes pulmonary diseases. A patient was admitted to our hospital with fever and cough. Chest radiography revealed consolidation in the right middle lung. As he had previously been treated for organizing pneumonia (OP), diagnosed OP recurrence administered systemic corticosteroids. Although initial improvement observed, consolidations worsened. Transbronchial lung cryobiopsy an pattern. M. identified...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHighly Efficient and Selective Cross-Linking to Cytidine Based on a New Strategy for Auto-Activation within DuplexFumi Nagatsugi, Takeshi Kawasaki, Daisaku Usui, Minoru Maeda, Shigeki SasakiView Author Information Graduate School of Pharmaceutical Sciences Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 28, 6753–6754Publication Date (Web):July 3, 1999Publication History Received5...
Acute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation and increased permeability of lung microvascular cells. CD26/dipeptidyl peptidase-4 (DPP4) a type II membrane protein that expressed in several cell types mediates multiple pleiotropic effects. We previously reported DPP4 inhibition sitagliptin attenuates lipopolysaccharide (LPS)-induced injury mice. The current study the functional role CD26/DPP4 expression LPS-induced mice, isolated alveolar...
Two anti-fibrotic drugs, pirfenidone (PFD) and nintedanib (NTD), are currently used to treat idiopathic pulmonary fibrosis (IPF). Peripheral blood mononuclear cells (PBMCs) immunocompetent that could orchestrate cell–cell interactions associated with IPF pathogenesis. We employed RNA sequencing examine the transcriptome signature in bulk PBMCs of patients effects drugs on these signatures. Differentially expressed genes (DEGs) between “patients healthy controls” “before after treatment” were...
Recently, we have proposed a new concept for cross-linking agents with inducible reactivity, in which the highly reactive agent, 2-amino-6-vinylpurine nucleoside analogue (1), can be regenerated situ from its stable precursors, phenylsulfide (4) and phenylsulfoxide (3) derivatives, by hybridization-promoted activation process selectivity to cytidine. The precursor exhibited ability despite high stability toward strong nucleophiles such as amines thiols. In this study, investigated...
Exposure to hypoxia induces changes in the structure and functional phenotypes of cells composing pulmonary vascular wall from larger most peripheral vessels. Endothelial progenitor (EPCs) may be involved endothelial repair. Resident EPCs with a high proliferative potential are found microcirculation. However, their location, identification, role have not been clearly established. We investigated whether resident or bone marrow (BM)-derived play major hypoxic response (PVECs). Mice were...
Pulmonary vascular endothelial function may be impaired by oxidative stress in endotoxemia-derived acute lung injury. Growing evidence suggests that endothelial-to-mesenchymal transition (EndMT) could play a pivotal role various respiratory diseases; however, it remains unclear whether EndMT participates the injury/repair process of septic Here, we analyzed lipopolysaccharide (LPS)-treated mice whose total number pulmonary cells (PVECs) transiently decreased after production reactive oxygen...
Sarcoidosis is a granulomatous systemic disease of unknown etiology. Mononuclear cells such as macrophages or lymphocytes in lung tissue and hilar mediastinal lymph nodes have been recognized to play an essential role granuloma formation pulmonary sarcoidosis. Peripheral blood mononuclear (PBMCs) consist several immunocompetent shown mechanistic the pathogenesis However, genetic modifications that occur bulk PBMCs sarcoidosis remain be elucidated.This study aimed explore pathobiological...
While sorafenib (SFN) is the established worldwide standard therapeutic agent for advanced hepatocellular carcinoma (HCC), hepatic arterial infusion chemotherapy (HAIC) also considered a favorable treatment some HCCs. This study aimed to evaluate each and provide an optimal choice We analyzed 72 patients treated with SFN 128 receiving HAIC. Both groups were prognostic disease progression factors, matched pair analysis was performed using propensity score matching method. The preferable...
Pulmonary vascular endothelial cells could contribute to maintain homeostasis in adult lung vasculature. "Tissue-resident" progenitor (EPCs) play pivotal roles postnatal vasculogenesis, repair, and tissue regeneration; however, their local pulmonary counterparts remain be defined. To determine whether prominin-1/CD133 expression can a marker of tissue-resident EPCs the circulation, we examined origin characteristics prominin-1/CD133-positive (Prom1(+)) PVECs considering cell cycle status,...
An increased risk of sarcoidosis and sarcoid-like reactions in subjects with a history malignancy has been suggested. We assessed the incidence clinical characteristics cancer patients biopsies containing granulomas on metastasis patient survival.This is retrospective, multicentre, observational study involving endobronchial ultrasound transbronchial needle aspiration melanoma dataset at University Miami, USA, database Chiba University, Japan. Subjects confirmed diagnosis who subsequently...
Nontuberculous mycobacterial (NTM) diseases are difficult-to-treat infections, especially in lung transplant (LTx) candidates. Currently, there is a paucity of recommendations on the management NTM infections LTx, focusing Mycobacterium avium complex (MAC), M. abscessus and kansasii.Pulmonologists, infectious disease specialists, LTx surgeons Delphi experts with expertise were recruited. A patient representative was also invited. Three questionnaires comprising questions multiple response...
Excessive inflammation in the lung is a primary cause of acute respiratory distress syndrome (ARDS). CD26/dipeptidyl peptidase-4 (DPP4) transmembrane protein that expressed various cell types and exerts multiple pleiotropic effects. We recently reported pharmacological CD26/DPP4 inhibition ameliorated lipopolysaccharide (LPS)-induced injury mice exerted anti-inflammatory effects on human microvascular endothelial cells (HLMVECs), vitro. However, mechanistic roles its HLMVECs remain unclear....
Abstract The pathogenesis of pulmonary fibrosis involves complex interplay between cell types and signaling pathways. Recurrent alveolar epithelial injury can occur during inflammation, causing dysregulation repair. Dysregulated repair interacts with mesenchymal, inflammatory, endothelial cells to trigger fibroblast‐to‐myofibroblast activation. CD26/dipeptidyl peptidase‐4 (DPP4) is a type II membrane protein mediating pleiotropic effect. However, the mechanistic role CD26/DPP4 in remains...
Non-emphysematous chronic obstructive pulmonary disease (COPD), which is defined based on chest computed tomography findings, presented different transcriptome features of peripheral blood mononuclear cells (PBMCs) compared with emphysematous COPD. Enrichment analysis transcriptomic data in COPD demonstrated that the “Hematopoietic cell lineage” pathway Kyoto Encyclopedia Genes and Genomes was highly upregulated, suggesting cellular dynamic dysregulation lungs affected by pathologically...