A5061620478- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Folate and B Vitamins Research
- Microtubule and mitosis dynamics
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Hippo pathway signaling and YAP/TAZ
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Blood disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
Kumamoto University
2016-2025
Kumamoto University Hospital
2016-2025
Keio University
2010-2012
Institute for Advanced Medical Research
2011
Japan Science and Technology Agency
2011
Fukuoka University
1997
In the mitotic exit network of budding yeast, Dbf2 kinase phosphorylates and regulates Cdc14 phosphatase. contrast, no phosphatase substrates LATS1/WARTS kinase, mammalian equivalent Dbf2, has been reported. To address this discrepancy, we performed phosphoproteomic screening using LATS1 kinase. Screening identified MYPT1 (myosin phosphatase–targeting subunit 1) as a new substrate for LATS1. directly preferentially phosphorylated serine 445 (S445) MYPT1. An mutant (S445A) failed to...
There is a currently an unmet need for non-invasive methods to predict the risk of esophageal squamous cell carcinoma (ESCC). Previously, we found that specific soft palate morphologies are strongly associated with increased ESCC risk. However, there no artificial intelligence (AI) system utilizes oral images assessment. Here, evaluated three AI models and fine-tuning approaches regard their predictive power. Our dataset contained 539 cases, which were subdivided into 221 high-risk cases...
Introduction: Index colonoscopy findings can affect surveillance decisions that have an impact on the future risk of colorectal cancer (CRC). However, effectiveness in reducing CRC remains unclear. This study aimed to evaluate whether timing first affected incidence rates. Methods: We conducted a retrospective cohort at two community endoscopy clinics between 2005 and 2021, including 20,397 individuals. Based index colonoscopy, we categorized into four groups: advanced adenoma (AA), ≥3...
The aim of this study was to evaluate structural and functional alterations human serum albumin (HSA), with a special focus on the oxidized reduced forms, in patients chronic liver disease. We also investigated whether oral branched-chain amino acid (BCAA) supplementation could induce changes improve functions HSA.The proportion HSA determined 16 healthy controls 20 hepatitis 100 cirrhotic stable conditions. To properties HSA, focused antioxidant binding functions. radical scavenging...
The adenoma‑carcinoma sequence, the sequential mutation and deletion of various genes by which colorectal cancer progresses, is a well‑established accepted concept carcinogenesis. Proteins polycomb repressive complex 2 (PRC2) function as transcriptional repressors trimethylating histone H3 at lysine 27; activity this essential for cell proliferation differentiation. methyltransferase enhancer zeste homolog (EZH2), an component PRC2, associated with repression tumor suppressor genes. EZH2...
The aim was to localise and characterise dystrophin in various human tissues, especially the CNS. Immunoblotting immunostaining studies were carried out with eight region-specific antibodies. In necropsy tissue from controls, noted as a doublet immunoblots of striated muscle, single band those smooth muscle With immunostaining, punctate immunoreactivity seen on cell bodies dendrites cerebral cortical neurons cerebellar Purkinje cells. By contrast, not detected any including cerebrum...
Cdh1 is an activator of the anaphase-promoting complex/cyclosome and contributes to mitotic exit G(1) maintenance by targeting cell cycle proteins for degradation. However, expressed active in postmitotic or quiescent cells, suggesting that it has functions other than control. Here, we found homozygous gene-trapped (Cdh1(GT/GT)) mouse embryonic fibroblasts (MEFs) Cdh1-depleted HeLa cells reduced stress fiber formation significantly. The GTP-bound Rho protein was apparently decreased cells....
Abstract The incidence rate of esophagogastric junction ( EGJ ) adenocarcinoma has been rapidly increasing worldwide. Carcinoembryonic antigen CEA and carbohydrate 19‐9 CA 19‐9) are major serum tumor markers in gastrointestinal cancers. However, the role these not thoroughly investigated. A total 211 patients with who underwent surgery or endoscopic submucosal dissection at two academic institutions, Kumamoto University Hospital Kyushu between January 1996 March 2014, were eligible for this...
While sorafenib (SFN) is the established worldwide standard therapeutic agent for advanced hepatocellular carcinoma (HCC), hepatic arterial infusion chemotherapy (HAIC) also considered a favorable treatment some HCCs. This study aimed to evaluate each and provide an optimal choice We analyzed 72 patients treated with SFN 128 receiving HAIC. Both groups were prognostic disease progression factors, matched pair analysis was performed using propensity score matching method. The preferable...
Metastatic cancers of the pancreas are rare, accounting for approximately 2-4% all pancreatic malignancies. Renal cell carcinoma is most common solid tumor that metastasizes to pancreas. Here, we present a case uterine cervical metastasizing and review literature regarding this rare event. A 44-year-old woman with had undergone radical hysterectomy been diagnosed pathologically stage Ib mixed adenoneuroendocrine in 2004. She underwent concurrent radiotherapy chemotherapy postoperatively....
Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case CMV enterocolitis during steroid therapy for an irAE. A 77-year-old man unresectable malignant melanoma was treated ipilimumab. He suffered from colitis (irColitis) and methylprednisolone. corticosteroids initially improved his symptoms, occurred...
Metastasis of gastrointestinal stromal tumor (GIST) into the central nervous system is extremely rare. We report a patient with synchronous GIST and brain metastasis. At disease onset, there was left hemiplegia ptosis right eyelids. Resection cytology reported as metastasis GIST. After positron emission tomography examination, another in small bowel discovered, which suggested associated intracranial Immunohistochemical analysis intestinal specimen obtained by double balloon endoscopy showed...
Right colon polyps can especially be overlooked when they are located on the backs of haustral folds. Previous studies have reported that repeated forward-view examinations in right were effective reducing adenoma miss rates. The aim this study was to clarify impact retroflexion after examinations.This multicenter, prospective, observational conducted at three institutions Kumamoto, Japan, between February 2014 and December 2015. Subjects who over 40 years old scheduled for colonoscopy...
Various key cell cycle components, especially G0/G1 regulators, have effects not only on proliferation but also differentiation. Cdh1, one of the co-activators that maintain anaphase-promoting complex/cyclosome activity, plays a crucial role in mitotic phase, has recently been identified as regulator, suggesting Cdh1 Here, we generated conditional gene-trap mice to examine functions adult tissues by overcoming embryonic lethality homozygous mice. We focused hematopoietic system and found...
We describe a case of small bowel Crohn's disease in which dual-energy computed tomography enterography using dual-layer spectral detector scanner contributed to quantitative assessment, and provided higher degree confidence pertaining the diagnosis. Dual-layer enables retrospective analysis including virtual monochromatic imaging, iodine mapping, determining effective atomic number Z with routine scan protocols. These advanced parametric imaging holds promising potential as an biomarker for...
Anti-tumor necrosis factor (TNF)-α therapy is established as a new standard for the treatment of various autoimmune inflammatory diseases. We report first case showing subacute thyroiditis-like symptoms with an amyloid goiter after anti-TNF-α therapy. A 56-year-old man Crohn's disease presented fever and diffuse, tender goiter. To control diarrhea, anti-TNF (infliximab) was administered 4 weeks before thyroid emerged. The patient reported swollen neck tenderness on right side days second...
Immune checkpoint inhibitors can affect any organ, including the salivary glands. A case of Sjögren's syndrome (SjS) induced by nivolumab for treatment gastric cancer is herein presented. Nivolumab caused marked tumor shrinkage, but xerostomia developed after two cycles. It took 3 months symptom onset to confirm diagnosis SjS. Prednisolone and pilocarpine hydrochloride did not relieve symptoms. SjS a relatively rare immune-related adverse event that might sometimes be overlooked. Since...
The long-term use of proton pump inhibitors (PPIs) has been reported to be strongly associated with the development fundic gland polyps (FGPs). Conversely, a few cases gastric hyperplastic (GHPs) PPI have reported. We experienced case PPI-associated multiple GHPs uncontrollable bleeding.
We report a rare case of primary hepatic gastrinoma. A 77-year-old woman exhibited continuous watery diarrhea for 8 months and weight loss. Bacterial cultures the stools were negative colonoscopy revealed no abnormalities. Esophagogastroduodenoscopy showed severe reflux esophagitis multiple duodenal erosions. Computed tomography magnetic resonance imaging detected two solid masses measuring <2 cm in diameter right lobe non-cirrhotic liver. Microscopically, tumor was consistent with...
In Japan, risk stratification after baseline colonoscopy is not widely accepted. We investigated the findings of colonoscopies at 17 community practices and evaluated incidence advanced neoplasia over a 5-year period.This retrospective cohort study enrolled 3115 subjects 40 years age who underwent had least one repeated within 5 years. Each group was classified based on endoscopic colonoscopy: no neoplasia/diminutive polyp <5 mm (N/D); small adenoma <10 mm; adenoma; invasive cancer,...