A5024376962- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Appendicitis Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic function and diabetes
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Glycosylation and Glycoproteins Research
- Biliary and Gastrointestinal Fistulas
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Lung Cancer Research Studies
- Liver Disease and Transplantation
- Phagocytosis and Immune Regulation
- Metastasis and carcinoma case studies
Kumamoto Medical Center
2015-2024
Kumamoto University
2005-2023
Nagasaki International University
2023
Symbiosis Group
2015
Nara Medical University
2015
Symbiosis International University
2015
Massachusetts General Hospital
2010
Shriners Hospitals for Children
2010
Harvard University
2010
Ehime University
2009
Autophagy is mostly a nonselective bulk degradation system within cells. Recent reports indicate that autophagy can act both as protector and killer of the cell depending on stage disease or surrounding cellular environment (for review see Cuervo, A.M. 2004. Trends Cell Biol. 14:70–77). We found cytoplasmic vacuoles induced in pancreatic acinar cells by experimental pancreatitis were autophagic origin, demonstrated microtubule-associated protein 1 light chain 3 expression electron microscopy...
Practical guidelines for the diagnosis of acute pancreatitis are presented so that a rapid and adequate can be made. When is suspected in patients with onset abdominal pain tenderness mainly upper abdomen, made on basis elevated levels pancreatic enzymes blood and/or urine. Furthermore, other diseases ruled out if local findings associated confirmed by diagnostic imaging. According to criteria established Japan, who present two following three manifestations diagnosed as having pancreatitis:...
Serine protease inhibitor, Kazal type 1 (SPINK1) is expressed not only in normal human pancreatic acinar cells but also a variety of ductal neoplasms. There are structural similarities between SPINK1 and epidermal growth factor (EGF). Hence, we hypothesized that binds to EGF receptor (EGFR) activate its downstream signaling. We first showed induced proliferation NIH 3T3 cancer cell lines. coprecipitated with EGFR an immunoprecipitation experiment the binding affinity was about half using...
The assessment of severity at the initial medical examination plays an important role in introducing adequate early treatment and transfer patients to a facility that can cope with severe acute pancreatitis. Under these circumstances, "criteria for assessment" have been prepared various countries, including Japan, criteria are now being evaluated. pancreatitis Japan were determined 1990 (of which partial revision was made 1999). In 2008, overall new Japanese prepared. assessment, diagnosis...
The dynamic aspects of circulating cytokines and cytokine modulators their relationship with development multiple organ failure (MOF) in patients acute pancreatitis were analyzed. All C-reactive protein levels the circulation higher than those MOF group. In particular, plasma concentrations soluble tumor necrosis factor receptors (sTNF-RI sTNF-RII) significantly without even at admission. Furthermore, sTNF-Rs interleukin-1 (IL-1) receptor antagonist (IL-1ra) much counterparts, TNFalpha...
To evaluate the clinical applicability of determination disseminated intravascular coagulation (DIC) parameters in acute pancreatitis.The subjects for this study were 139 consecutive patients with pancreatitis. DIC assessed at initial observation these patients.The levels admission significantly associated severity and prognosis Antithrombin III (AT-III), fibrin/fibrinogen degradation products-E, platelet count, D-dimer, thrombin-AT-III complex showed better area under receiver operating...
Pancreatitis remains the most common severe complication of endoscopic retrograde cholangiopancreatography (ERCP). Detailed information about findings previous studies concerning post-ERCP pancreatitis has not been utilized sufficiently. The purpose present article was to guidelines for diagnostic criteria pancreatitis, and its incidence, risk factors, prophylactic procedures that are supported by evidence. To achieve this purpose, a critical examination made articles on based data obtained...
While statin intake has been proven to reduce the risk of colorectal cancer (CRC), mechanism antitumor effects and clinical significance in survival benefits remain unclear. Statin-induced antiproliferative its underlying were examined using six CRC cell lines. Statins except pravastatin showed (simvastatin ≥ fluvastatin > atorvastatin) even though both simvastatin could activate mevalonate pathways, suggesting statin-mediated depended on non-mevalonate pathway. Indeed, induced p27(KIP1)...