A5032591032- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- 14-3-3 protein interactions
- Respiratory and Cough-Related Research
- Nosocomial Infections in ICU
- Eosinophilic Disorders and Syndromes
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Anesthesia and Sedative Agents
- Vascular Anomalies and Treatments
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Transplantation: Methods and Outcomes
Japanese Red Cross Narita Hospital
2025
Chiba University
2014-2024
Chiba University Hospital
2021-2024
Tohoku Medical and Pharmaceutical University
2022
NTT Medical Center
2011-2019
Kin-ikyo Chuo Hospital
2013
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
Rationale: Acute exacerbation during the course of idiopathic pulmonary fibrosis causes a poor prognosis. Coagulation abnormalities and endothelial damage are involved in its pathogenesis. Thrombomodulin alfa, recombinant human soluble thrombomodulin, has anticoagulant antiinflammatory effects. Several clinical studies have shown that thrombomodulin alfa may improve survival acute exacerbation.Objectives: To determine efficacy safety compared with placebo fibrosis.Methods: This randomized,...
To evaluate the effects of tiludronate on mass, structure, and turnover cancellous bone regions in immobilized rat tibiae, we performed a 4 week dosing experiment. The right hindlimbs 84 Sprague-Dawley rats (5 weeks old) wee neurectomized or sham operated. Animals were assigned to seven groups (n = 12 each); group 1 was operated, 2-7 neurectomized. Groups 2 given vehicle only (distilled water), 3, 4, 5 orally at doses 25, 50, 100 mg/kg body weight (BW)/day, respectively, throughout...
To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess responsiveness such initial treatment, and associations between these patient disease characteristics mortality.We retrospectively identified 167 consecutive hospital-based MPA 3 hospitals Japan. We longitudinally collected clinical information for 150 patients, whom CT images obtained before treatment were available. then determined presence 22...
Abstract Mycobacterium goodii , a rapidly growing non‐tuberculous mycobacterium, rarely causes pulmonary diseases. A patient was admitted to our hospital with fever and cough. Chest radiography revealed consolidation in the right middle lung. As he had previously been treated for organizing pneumonia (OP), diagnosed OP recurrence administered systemic corticosteroids. Although initial improvement observed, consolidations worsened. Transbronchial lung cryobiopsy an pattern. M. identified...
Two anti-fibrotic drugs, pirfenidone (PFD) and nintedanib (NTD), are currently used to treat idiopathic pulmonary fibrosis (IPF). Peripheral blood mononuclear cells (PBMCs) immunocompetent that could orchestrate cell–cell interactions associated with IPF pathogenesis. We employed RNA sequencing examine the transcriptome signature in bulk PBMCs of patients effects drugs on these signatures. Differentially expressed genes (DEGs) between “patients healthy controls” “before after treatment” were...
Purpose: Acute exacerbation (AE) is an important outcome of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Recombinant human soluble thrombomodulin (rhTM) a new drug for the treatment disseminated intravascular coagulation in Japan. The objective this study was to evaluate efficacy rhTM AE IPF/NSIP. Methods: Twenty-two patients with AE-idiopathic (16 IPF six NSIP) were enrolled our study. Among them, eleven treated (rhTM group), without (non-rhTM group)....
Sarcoidosis is a granulomatous systemic disease of unknown etiology. Mononuclear cells such as macrophages or lymphocytes in lung tissue and hilar mediastinal lymph nodes have been recognized to play an essential role granuloma formation pulmonary sarcoidosis. Peripheral blood mononuclear (PBMCs) consist several immunocompetent shown mechanistic the pathogenesis However, genetic modifications that occur bulk PBMCs sarcoidosis remain be elucidated.This study aimed explore pathobiological...
Among the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a candidate found in proteomic analysis. The study includes two independent cohorts (including totally 26 patients DAD) and controls (total 432 samples). SFN specifically elevated DILD DAD, superior to known biomarkers, KL-6 SP-D,...
The INPULSIS-ON trial demonstrated that nintedanib reduced decline in forced vital capacity (FVC) and low pulmonary function (%FVC < 50%) of patients with idiopathic fibrosis (IPF). However, there is no sufficient evidence real world.Reveal the utility adverse events for severe IPF patients.This was a single-center retrospective study. Patients who met eligibility criteria INPULSIS ≥ 50%; %DLCO [diffusing lung carbon monoxide % predicted] 30%) were classified as Mild to Moderate Group (n =...
Abstract Drug-induced interstitial lung disease (DILD) occurs when drug exposure causes inflammation of the interstitium. DILD can be caused by different types drugs, and some patterns results in a high mortality rate; hence, poses serious problem clinical practice as well development, strategies to diagnose distinguish from other diseases are necessary. We aimed identify novel biomarkers for performing lipidomics analysis on plasma samples patients with acute recovery phase DILD. Having...
Abstract Background and Objective The possibility of combination therapy with atomoxetine (ATO) oxybutynin (OXY) has been suggested for obstructive sleep apnoea (OSA). However, the effectiveness this treatment remains uninvestigated in Japanese OSA patients. Therefore, we performed a randomized, crossover, phase II, single‐centre prospective trial to examine effects ATO–OXY Methods In total, 17 patients participated study. one night 80‐mg ATO plus 5‐mg OXY administration were compared those...
<b><i>Background:</i></b> Although appropriate sedation is recommended during flexible bronchoscopy (FB), patients are at risk for hypoventilation due to inadvertent oversedation. End-tidal capnography expected as an additional useful monitor these FB. <b><i>Objectives:</i></b> The aim of this study was evaluate the benefit end-tidal monitoring in reducing incidence hypoxemia FB under sedation. <b><i>Methods:</i></b>...
Abstract Drug‐induced lung injury is an adverse effect of drug treatment that can result in respiratory failure. Because lipid profiling could provide cutting‐edge understanding the pathophysiology toxicological responses, we performed lipidomic analyses drug‐induced injury. We used a mouse model bleomycin‐induced and followed physiological responses at acute inflammatory (day 2), inflammatory‐to‐fibrosis 7) fibrosis 21) phases. The overall profiles plasma, bronchoalveolar lavage fluid...
Although pirfenidone (PFD) is a key drug for the treatment of idiopathic pulmonary fibrosis (IPF), differences in tolerability between elderly and young patients remain unclear. This study aimed to investigate age-related adverse reactions PFD evaluate whether patient age influences safety clinical practice.One hundred fifty-four with IPF were treated our institution May 2009 April 2017; these classified into 2 groups on basis age: ≥75 years (elderly patients) <75 (younger patients). In each...
A 17-year-old Japanese girl visited our hospital for an evaluation of exertional dyspnea. diagnosis pulmonary arterial hypertension (PAH) was confirmed based on the findings right heart catheterization. Detailed questioning revealed a family history hereditary hemorrhagic telangiectasia (HHT), and genetic mutation analysis disclosed in activin receptor-like kinase 1 gene (ACVRL1). The patient finally diagnosed with HHT according to Curaçao diagnostic criteria eight years after PAH. This case...
Rapid on-site evaluation (ROSE) of cytologic material is widely performed because it provides clinicians with instant diagnostic information. However, the utility ROSE touch imprint cytology (ROSE-TIC) during transbronchial biopsy (TBB) remains unclear. The aim this study was to evaluate feasibility and accuracy ROSE-TIC for TBB.A retrospective on patients who underwent bronchoscopy combined ROSE-TIC. results ROSE-TIC, diagnosed as either positive or negative malignancy, were compared...
Very recently, a modest but significant efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy for the treatment mild to moderate autoimmune pulmonary alveolar proteinosis (aPAP) has been reported. As ability measure level GM-CSF autoantibody (GMAb) in serum is required decide indication this therapy, we developed high-performance GMAb testing kit clinical use. succeeded reducing nonspecific IgG binding ELISA plate, predictive performance shown training...
Abstract Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been used to diagnose and stage lung cancer. Acquire™ Pulmonary Expect™ dedicated EBUS-TBNA needles were introduced as the Franseen Lancet needles, respectively. It is still unclear whether or yield a higher quality specimen especially focusing on next-generation sequencing-based molecular testing. Methods A single-center, prospective study performed at Chiba University Hospital randomly...
Serum levels of stratifin (SFN), a member the 14-3-3 protein family, increase in patients with drug-induced lung injury associated diffuse alveolar damage. Therefore, we hypothesised that SFN would be higher those experiencing acute exacerbation interstitial disease (AE-ILD). A secondary analysis was also planned to determine whether could discriminate survival AE. Thirty-two clinically stable ILD (CS-ILD) and 22 AE-ILD were examined assess high serum reflected severity or prognosis AE-ILD....
Abstract Background and Objective Intimal hyperplasia (IH) leading to restenosis is a major complication of arterial revascularization. The purpose this study was investigate the effect photodynamic therapy (PDT) using mono‐L‐aspartyl chlorin e6 (NPe6) as photosensitizer intraluminal radial irradiation for inhibition IH experimentally. Study Design/Materials Methods laser transmission through blood indicated that exclusion prerequisite PDT. For homogeneous vessel wall, we used newly...