A5017545532- Vaccine Coverage and Hesitancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Virology and Viral Diseases
- Hepatitis B Virus Studies
- Pulmonary Hypertension Research and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- Sarcoidosis and Beryllium Toxicity Research
- Immune responses and vaccinations
- Spectroscopy and Chemometric Analyses
- Venous Thromboembolism Diagnosis and Management
- Global Maternal and Child Health
- Atrial Fibrillation Management and Outcomes
- Hepatitis C virus research
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Pharmaceutical Quality and Counterfeiting
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- IgG4-Related and Inflammatory Diseases
- Peripheral Neuropathies and Disorders
- Gastrointestinal disorders and treatments
- Lymphatic Disorders and Treatments
- Healthcare Systems and Reforms
National Center for Global Health and Medicine
2011-2024
Center for Global Health
2011-2023
Ministry of Health Labour and Welfare
2020
Chiba University
2011-2019
St. Luke's International University
2017-2019
Chiba University Hospital
2014-2017
Aims The lung lesion [immunoglobulin (Ig)G4‐L] of IgG4‐related disease (IgG4‐ RD ) is a condition that occurs together with IgG4‐ and often mimics the [idiopathic multicentric Castleman's ( iMCD ‐L)] idiopathic ). Because no clinical pathological studies had previously compared features these diseases, we undertook this comparison histological data. Methods results Nine patients IgG4‐L (high levels serum IgG4 + cells in specimens; typical extrapulmonary manifestations). Fifteen ‐L...
Background The avoidance of inhaled allergens or tobacco smoke has been known to have favorable effects on asthma control. However, it remains unclear whether other lifestyle-related factors are also related Therefore, a comprehensive study examine the associations between various lifestyle and control was conducted in Japanese asthmatic patients. Methods subjects included 437 stable patients recruited from our outpatient clinic over one-year period. A written, informed consent obtained each...
Purpose: Acute exacerbation (AE) is an important outcome of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Recombinant human soluble thrombomodulin (rhTM) a new drug for the treatment disseminated intravascular coagulation in Japan. The objective this study was to evaluate efficacy rhTM AE IPF/NSIP. Methods: Twenty-two patients with AE-idiopathic (16 IPF six NSIP) were enrolled our study. Among them, eleven treated (rhTM group), without (non-rhTM group)....
An 80-year-old woman was admitted to our hospital with pneumonia and exacerbation of sinobronchial syndrome (SBS). She presented yellow discoloration the nail beds all fingers toes, her nails were recognized as growing slowly. Chest X-ray revealed bronchiectasis in bilateral lower lobe pleural effusion. We diagnosed having (YNS), based on triad nails, lymphedema, lung disease. After treatment antibiotics [ampicillin/sulbactam clarithromycin (CAM)] for SBS, general condition improved,...
Vietnam continues to have measles and rubella outbreaks following supplementary immunization activities (SIA) routine despite both having high reported coverage. To evaluate activities, age-specific immunity against rubella, the number of averted Congenital Rubella Syndrome (CRS) cases, must be estimated.
The prognosis of patients with an acute exacerbation interstitial pneumonia (AE-IP) is poor. Pirfenidone (PFD) reduces the disease progression in idiopathic pulmonary fibrosis.The purpose this study was evaluating whether administration PFD improved outcomes AE-IP.We conducted a retrospective 31 AE-IP who did not recover between 7 and 14 days after initial treatment. Fourteen received within 2 weeks (PFD group) AE, while 17 were treated without (non-PFD group). patients' clinical data...
Immunization is one of the most important public health interventions for reducing morbidity and mortality in children. However, factors contributing to low immunization coverage are not fully understood Lao People's Democratic Republic (Lao PDR). Therefore, this study aimed identify associated with full among children between 12 35 months, providing up-to-date information programs PDR. We analyzed subpopulation a nationwide cross-sectional survey using multistage cluster sampling procedure...
Vietnam introduced a 3-dose hepatitis B (HBV) immunization program comprising 1 dose immediately after birth and 2 or 3 in infancy the past 20 years, but impact of vaccine has not been systematically evaluated. Thus, we conducted this survey aiming to estimate age-specific chronic HBV prevalence general population evaluate effectiveness.
This study aimed to determine the agreement between a rapid diagnostic test (RDT) and dried blood spot (DBS)-based electrochemiluminescence immunoassay (ECLIA) of hepatitis B surface antigen compare costs conducting serosurveys using RDTs DBS in field setting.A serosurvey was conducted South Central Coast region Vietnam May 2019. Participants aged 1-39 years were recruited four-stage random sampling method tested for an RDT kit (Alere Determine) DBS-based ECLIA. The ECLIA assessed...
We evaluated the effectiveness of Lao People's Democratic Republic's measles-rubella immunization program using seroprevalence from two cross-sectional surveys.The nationwide surveys occurred in 2014 and 2019 a multistage cluster sampling, both requiring samples 2184 individuals 52 randomly selected villages. Immunoglobulin G titers, measured enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) ≥10 IU/ml (rubella). calculated vaccination-related reduction...
This study aimed to assess measles and rubella immunity by measuring virus-specific immunoglobulin G (IgG) prevalence among individuals evaluate the effectiveness of recent supplementary immunization activities (SIAs) comparing antibody positivity rates SIA target age groups in 2015 with those 2019 as are endemic Papua New Guinea. A cross-sectional study. The measles- rubella-specific IgG levels patients aged ≥1 year at two clinics East Sepik province, Guinea were assessed commercially...
In this work, we optimized classification algorithms and the hyperparameters for screening falsified substandard amoxicillin capsules. The distribution of low-quality medical products is a serious problem, especially in low- middle-income countries. Near-infrared (NIR) spectroscopy has been proposed as first choice device. However, preparation reference library training highly difficult process. We herein propose hetero-device between test devices. proposal, Fourier-transform NIR...
Population-based seroprevalence of chronic hepatitis B and C infections has not been examined in Lao People’s Democratic Republic (PDR). Therefore, this study aimed to estimate the these general population PDR perform subgroup analysis. A nationwide survey was conducted June 2019 using multistage cluster sampling method. Dried blood spot samples were collected onto Whatman TM 903 filter paper by finger prick. chemiluminescent microparticle immunoassay used measure levels surface antigen...
The objective of this work is to demonstrate the potential near-infrared spectroscopy for common screening falsified medicines in field by means a device-independent universal discrimination approach. In order provide useful tool protect people from low-quality medical products, not only low-cost and portable device necessary, but reference library also essential. authors believe that device-dependent inhibits becoming popular tool. study, develop method, performance evaluated using...
Reflecting the experiences of COVID-19 pandemic, global response was reviewed by Independent Review Panel for Pandemic Preparedness and Response. Based on panel reports, World Health Organization (WHO) member states decided to establish intergovernmental negotiating body drafting a WHO convention, agreement or other international instrument pandemic prevention, preparedness response, aiming approval at 77
In 2015, Japan created a unique governmental program to train experts in health emergencies called Infectious Disease Emergency Specialist (IDES). This is concept paper set out the goal and structure of program, describe achievement way forward further contribute global security. The IDES background, mission, structure, achievement, future directions were reviewed discussed by trainees, graduates, coordinators/supervisors. Since thirteen Japanese medical doctors have graduated from while...
Background: In the Lao People's Democratic Republic (Lao PDR), vaccine preventable disease control is an important public health issue. 2014, first nationwide multistage random clusters sampling survey was conducted to determine socio-demographic factors affecting vaccination. After survey, national EPI two SIAs especially for measles. The Eighth National Health Sector Development Plan 2016–2020 includes a goal of at least 90% vaccination coverage by 2020, however, reported still low as...
Background: Measles, rubella, mumps, and varicella are currently endemic in Vietnam, while population immunity to these diseases among general is unknown. In this study, we evaluated age-specific susceptibility four Khan Hoa province. Methods materials: By applying probability proportionate size sampling, selected 480 adults who were their 20 70 years old from 30 randomly villages 10 communes/wards the 376 blood samples collected (response rate 78%). Specific immunoglobulin G (IgG) each...
Background: Vietnam is considered hyperendemic for hepatitis B and universal immunization among infants has been implemented since 2003. To implement better disease control policies, effective impact evaluation of the vaccination program warranted. Methods materials: We conducted a stratified, multistage, cluster sampling survey surface antigen (HBsAg) positivity people aged 1–39 years old. Participants were randomly selected from 4 provinces (Khanh Hoa, Ninh Thuan, Binh Dinh, Quang Ngai) in...
The World Health Organization (WHO) has been utilizing Emergency Use Listing (EUL) to expand access medical products during the COVID-19 pandemic. EUL is a risk-based procedure for assessing and listing unlicensed vaccines, medicine, in vitro diagnostics. To determine whether Japanese acquired relating COVID-19, we conducted desk research as part of new project. Results showed that thirteen twenty-eight diagnostic were from China three ten vaccines on India. However, only one vaccine...