A5054668950- Asthma and respiratory diseases
- Mast cells and histamine
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Vascular Anomalies and Treatments
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Eosinophilic Disorders and Syndromes
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Voice and Speech Disorders
- Drug-Induced Adverse Reactions
- Airway Management and Intubation Techniques
National Center for Global Health and Medicine
2015-2024
Center for Global Health
2013-2022
National Hospital of Sri Lanka
2021
National Disaster Medical Center
2007-2019
National Hospital Organization
2010-2019
Saitama International Medical Center
2008-2011
ENT and Allergy
2002-2008
The University of Tokyo
1997-2007
Stanford University
2005-2007
American Physical Therapy Association
1998
Small-cell lung cancer (SCLC) is a subgroup of with high frequency liver metastasis, which predictor poor prognosis. Diffuse metastases SCLC no visible nodular lesions in the when examined using computed tomography (CT) are relatively rare; however, few cases rapid progression to acute failure that were diagnosed after death have been reported. In this paper, we report 63-year-old man diffuse histologically transjugular biopsy while patient was alive, even though during contrast-enhanced CT...
Abstract We recently reported that mast cells stimulated via FcεRI aggregation can enhance T cell activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible for such IgE-, Ag- (Ag-), and cell-dependent enhancement of remain unknown. In this study we showed mouse bone marrow-derived cultured express various costimulatory molecules, including members B7 family (ICOS ligand (ICOSL), PD-L1, PD-L2) TNF/TNFR families (OX40 (OX40L), CD153, Fas, 4-1BB,...
Abstract Basophils are thought to play pivotal roles in allergic inflammation through rapid release of chemical mediators addition sustained production Th2 cytokines, including IL-4. A newly identified cytokine, IL-33, has been recognized as one the key cytokines enhancing Th2-balanced immune regulation its receptor, ST2. The present study was conducted elucidate whether IL-33 acts directly on, and affects functions of, human basophils. Real-time PCR analysis showed that basophils express...
Abstract The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcεRI-stimulated mouse mast cells. Another molecule, IL-33, was identified recently as a ligand for T1/ST2. Although cells constitutively express ST2, the effects of IL-33 on cell function are poorly understood. We found that but not IL-1β or induced IL-13 IL-6 bone marrow-derived, cultured (BMCMCs) independently IgE. In BMCMCs incubated with potently cytokinergic SPE-7 IgE without...
Background Viral infection is one of the risk factors for asthma exacerbation. However, which pathogens are related to exacerbation in adults remains unclear. Objective The relation between various infections and adult exacerbations was investigated clinical practice. Methods study subjects included 50 inpatients due 20 stable outpatients comparison. from a nasopharyngeal swab were measured by multiplex PCR analysis. Results Asthma occurred after common cold 48 inpatients. numbers patients...
The risk of pneumonia is increased among COPD patients using inhaled corticosteroids (ICS). However, there uncertainty regarding the association between long-term use ICS and exacerbations respiratory tract infections asthmatic patients.A case-control nested cohort study was performed to assess asthma with nontuberculous mycobacterium (NTM) infection.Among this 464 patients, 14 experienced complications due NTM infections, which eight were caused by Mycobacterium avium-intracellulare...
We examined the expression profile of chemokine receptors in human basophils and their regulation by cytokines. Basophils expressed transcripts CC (CCR)1, CCR2, CCR3, CCR5 CXC (CXCR)1, CXCR2, CXCR4. In contrast to other receptors, surface-CXCR4 was not detected fresh- whole-blood basophils, but it became apparent gradually during incubation. Among 16 chemokines tested, eotaxin induced most potent basophil migration. SDF-1 also a strong, migratory response comparable with that 24-h, cultured...
Both prostaglandin (PG) D receptor (DP) and CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)/DP2 are high-affinity receptors for PGD2. Previous studies have demonstrated that PGD2 enhances releasability induces CRTH2/DP2-mediated migration in human basophils, but the precise effects of basophils as well usage not been fully clarified.We comprehensively explored roles DP CRTH2/DP2 basophil functions by using selective agonists antagonists each receptor.DP...
Certain proteases derived from house dust mites and plants are considered to trigger initiation of allergic airway inflammation by disrupting tight junctions between epithelial cells. It is known that inhalation such as mite-derived Der p1 and/or papaya-derived papain caused eosinophilia in naïve mice even Rag-deficient lack acquired immune cells T, B NKT In contrast, little regarding the possible involvement Aspergillus species (fungal-associated proteases; FAP), which ubiquitous...
Abstract The Pfizer‐BioNTech mRNA vaccine (BNT162b2) is an effective and well‐tolerated coronavirus disease 2019 (COVID‐19) vaccine. However, rare adverse events have been reported. We report two cases of COVID‐19 vaccine‐related interstitial lung (ILD). A 67‐year‐old man a 70‐year‐old with underlying ILD presented to our hospital few days fever respiratory symptoms after receiving the BNT162b2 Drug‐related pneumonitis due was diagnosed. One case diagnosed lymphocytic alveolitis by...
Eotaxin is a potent and selective CC chemokine for eosinophils basophils. We established several monoclonal antibodies (Mabs) allowing the neutralization measurement of human eotaxin. Using Mabs as probes, we demonstrated that normal contained intracellular granule‐associated Quantification cell‐associated eotaxin in different leukocyte subsets revealed it was principally expressed eosinophils. Finally, showed released upon stimulation with either two secretagogues, C5a or ionomycin. These...
We examined whether secretory IgA (sIgA), known to mediate eosinophil stimulation, has an effect on basophil functions. An immobilized preparation of sIgA, but not monomeric IgA, induced histamine release (approximately 15% total contents) from human basophils in vitro. sIgA-induced was totally dependent pretreatment with IL-3. IL-5 and granulocyte-macrophage CSF also primed for sIgA-mediated release. Exogenous divalent ions, i.e., Ca2+ Mg2+, were essential degranulation, the degranulation...
Background IL-33, a member of the IL-1 family cytokines, provokes Th2-type inflammation accompanied by accumulation eosinophils through IL-33R, which consists ST2 and IL-1RAcP. We previously demonstrated that macrophages produce IL-33 in response to LPS. Some immune responses were shown differ between ST2-deficient mice soluble ST2-Fc fusion protein-treated mice. Even anti-ST2 antibody (Ab)-treated mice, phenotypes differed distinct Ab clones, because characterization such Abs (i.e.,...
Background The avoidance of inhaled allergens or tobacco smoke has been known to have favorable effects on asthma control. However, it remains unclear whether other lifestyle-related factors are also related Therefore, a comprehensive study examine the associations between various lifestyle and control was conducted in Japanese asthmatic patients. Methods subjects included 437 stable patients recruited from our outpatient clinic over one-year period. A written, informed consent obtained each...