A5081507149- Mast cells and histamine
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Click Chemistry and Applications
- Immune Response and Inflammation
- Drug-Induced Adverse Reactions
- Blood properties and coagulation
- Polyamine Metabolism and Applications
- Renal and related cancers
- Chemokine receptors and signaling
- COVID-19 Impact on Reproduction
- Neuropeptides and Animal Physiology
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Fibroblast Growth Factor Research
Seattle Children's Hospital
2012-2024
University of Washington
2011-2023
Children’s Institute
2019-2023
ORCID
2023
University of California, San Francisco
2023
Seattle University
2022
Pediatrics and Genetics
2022
Stanford University
2004-2013
Hebrew University of Jerusalem
1999-2006
Swedish University of Agricultural Sciences
2006
Snake or honeybee envenomation can cause substantial morbidity and mortality, it has been proposed that the activation of mast cells by snake insect venoms contribute to these effects. We show, in contrast, significantly reduce snake-venom-induced pathology mice, at least part releasing carboxypeptidase A possibly other proteases, which degrade venom components. Mast also reduced mortality induced venom. These findings identify a new biological function for enhancing resistance animal venoms.
Abstract: Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively suggests that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant many more aspects tissue physiology than just the generation inflammatory vasodilatory responses IgE‐dependent environmental antigens. And yet, for decades, mainstream‐mast cell research has been...
Mast cell degranulation is important in the pathogenesis of anaphylaxis and allergic disorders. Many animal venoms contain components that can induce mast degranulation, this has been thought to contribute pathology mortality caused by envenomation. However, we recently reported evidence cells enhance resistance mice certain snakes mouse cell-derived carboxypeptidase A3 (CPA3) effect. Here, investigated whether venom Gila monster, a toxic component (helodermin), structurally similar...
Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of asthma indirect airway hyperresponsiveness (AHR), prominent endotype the presence type 2 inflammation. underlying basis for inflammation its relationship to AHR are incompletely understood. We assessed expression cytokines in airways subjects with without who were extensively characterized AHR. Using quantitative morphometry wall, we...
Background Eosinophils are implicated as effector cells in asthma, but the functional implications of precise location eosinophils airway wall is poorly understood. We aimed to quantify different compartments and associate these findings with clinical features asthma markers inflammation. Methods In this cross-sectional study, we utilised design-based stereology accurately partition numerical density both epithelial compartment subepithelial space (airway area below basal lamina including...
Mouse mast cell protease 4 (mMCP-4), the mouse counterpart of human chymase, is thought to have proinflammatory effects in innate or adaptive immune responses associated with activation. However, chymase can degrade cytokine TNF, a mediator that be produced by cells and many other types. We found mMCP-4 reduce levels cell-derived TNF vitro through degradation transmembrane soluble TNF. assessed interactions between vivo analyzing features classic model polymicrobial sepsis, cecal ligation...