A5058684057- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Cutaneous Melanoma Detection and Management
- Fungal Infections and Studies
- Dermatologic Treatments and Research
- Plant Pathogens and Fungal Diseases
- Neurofibromatosis and Schwannoma Cases
- Skin Diseases and Diabetes
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Neuropeptides and Animal Physiology
- Hair Growth and Disorders
- Genetic and rare skin diseases.
- Dermatological and Skeletal Disorders
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Poxvirus research and outbreaks
- Cutaneous lymphoproliferative disorders research
- Nerve injury and regeneration
Jichi Medical University Saitama Medical Center
2008-2024
Jichi Medical University
2008-2024
Stanford University
2005-2006
Juntendo University
2005
Abstract We recently reported that mast cells stimulated via FcεRI aggregation can enhance T cell activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible for such IgE-, Ag- (Ag-), and cell-dependent enhancement of remain unknown. In this study we showed mouse bone marrow-derived cultured express various costimulatory molecules, including members B7 family (ICOS ligand (ICOSL), PD-L1, PD-L2) TNF/TNFR families (OX40 (OX40L), CD153, Fas, 4-1BB,...
Abstract Mast cells represent a potential source of TNF, mediator which can enhance dendritic cell (DC) migration. Although the importance mast cell-associated TNF in regulating DC migration vivo is not clear, and cell-derived contribute to expression certain models contact hypersensitivity (CHS). We found that CHS FITC was significantly impaired cell-deficient KitW-sh/W-sh or TNF−/− mice. The reduced mice fully repaired by local transfer wild-type bone marrow-derived cultured (BMCMCs), but...
Mast cells are not only important effector in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute T cell-mediated disorders. However, the mechanisms by which mast might influence such settings fully understood. We find that enhance proliferation cytokine production multiple cell subsets. cell-dependent enhancement of activation be promoted FcepsilonRI-dependent activation, TNF both cells, cell-T contact. at high concentrations promote independent...
The skin microbiome at lesion sites in patients with atopic dermatitis (AD) is characterized by dysbiosis. Although the administration of dupilumab, an IL-4Rα inhibitor, improves dysbiosis bacterial microbiome, information regarding fungal remains limited. This study administered dupilumab to 30 moderate-to-severe AD and analyzed changes both microbiomes over a 12-week period. Malassezia restricta M. globosa dominated whereas non-Malassezia yeast species increased abundance, leading greater...
Th2 and Th1 cells have been suggested to express CCR3/CCR4 CCR5/CXCR3, respectively.We examined CCR3, CCR4, CCR5 CXCR3 expression cytokine production in peripheral blood CD4+ T from patients with atopic dermatitis (AD), which has postulated be a Th2-type cell-mediated disease, then analysed the possible correlation between these values levels of several clinical parameters.Intracellular chemokine receptor 40 AD 20 sex- age-matched healthy control subjects were studied by flow cytometry.The...
A 12‐year‐old Japanese boy presented with asymptomatic, multiple annular, erythematous, infiltrated lesions on his left upper arm and right knee as well the lateral side of ankle joint. He had noted these erythematous five days after bacille Calmette‐Guerin (BCG) vaccination. The gradually enlarged increased in number. Topical corticosteroid therapy for several weeks failed to improve lesions. There was no familial history pulmonary tuberculosis. Physical examination revealed extensively...
A 58-year-old Japanese male visited us with painful lesions on the lower lip, oral mucosa and genital region of an 8-month duration. Histological features lesion were almost consistent lichenoid tissue reaction. few intraepidermal acantholytic keratinocytes also seen in suprabasal clefts. Direct immunofluorescence exhibited cell surface immunoglobulin (Ig)G deposition linear fibrinogen at dermoepidermal junction. IgG anti-desmoglein (Dsg)3 antibody, but not anti-Dsg1 was detected patient's...
Overexpression of vascular endothelial growth factor (VEGF) in epidermal lesions psoriasis is well documented; however, its underlying mechanisms are largely unknown. We have recently demonstrated that vasoactive intestinal peptide (VIP) induces the production cytokines such as interleukin-6 and stem cell from keratinocytes, thereby contributing to development inflammatory dermatoses psoriasis.In this study, we attempted determine whether VIP could increase VEGF human keratinocytes.We...
Journal Article Recalcitrant pemphigus foliaceus with Kaposi's varicelliform eruption: report of a fatal case Get access T. Demitsu, Demitsu Departments Dermatology, Jichi Medical University Saitama Centre, Saitama, Japan and School Medicine, Shimotsuke, Dr Toshio Department 1‐847 Amanuma‐cho, Omiya‐ku, 330‐8503, Japan. E‐mail: demitsu@omiya.jichi.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Kakurai, Kakurai R. Azuma, Azuma Y. Hiratsuka, Hiratsuka Yamada,...
Bullous pemphigoid (BP) is a common autoimmune blistering disorder with unknown etiology. Recently, increasing numbers of BP cases which developed under the medication dipeptidyl peptidase-4 inhibitors (DPP4i), widely used antihyperglycemic drugs, have been reported in published works. Here, we report case DPP4i (teneligliptin)-associated that 70-year-old Japanese man. Interestingly, patient had acquired reactive perforating collagenosis (ARPC), also known to be associated onset BP. In...
Abstract A 61‐year‐old Japanese man developed bullous skin lesions during topical therapy for psoriasis vulgaris. Physical examination demonstrated numerous tense bullae and scaly erythemas on the trunk extremities. Histopathology of biopsy subepidermal lymphocytic infiltration with eosinophils in dermis. Direct immunofluorescence revealed linear deposits immunoglobulin (Ig)G, IgA C3 along basement membrane zone. Indirect 1 mol/L NaCl‐split showed IgG reactivity both epidermal dermal sides....