A5003169881- Gastrointestinal disorders and treatments
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Food Allergy and Anaphylaxis Research
- Infectious Encephalopathies and Encephalitis
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Bacterial Infections and Vaccines
- RNA modifications and cancer
- Inflammatory Myopathies and Dermatomyositis
- Neuroblastoma Research and Treatments
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Allergic Rhinitis and Sensitization
- Aortic aneurysm repair treatments
- Autoimmune and Inflammatory Disorders Research
- Abdominal vascular conditions and treatments
- Infectious Aortic and Vascular Conditions
- Inflammatory Bowel Disease
- Vasculitis and related conditions
- Pediatric Urology and Nephrology Studies
- Microscopic Colitis
Dokkyo Medical University
2020-2025
Tokuyama (Japan)
2003-2025
Japan Community Healthcare Organization
2023-2025
Gunma University
2024
NTT Medical Center
2019-2024
Pediatrics and Genetics
2021
Kyoto Prefectural University of Medicine
1973-2020
Chiba University
2019-2020
Kin-ikyo Chuo Hospital
2019
Tokushima University
2016-2017
Abstract Atopic dermatitis ( AD ) is a disease characterized by relapsing eczema with pruritus as primary lesion. The current strategies to treat in Japan from the perspective of evidence‐based medicine consist three measures: (i) use topical corticosteroids and tacrolimus ointment main treatment for inflammation; (ii) application emollients cutaneous barrier dysfunction; (iii) avoidance apparent exacerbating factors, psychological counseling advice about daily life. guidelines present...
Recent studies have shown that metastasis‐associated lung adenocarcinoma transcript 1 ( MALAT 1) was overexpressed in many human solid cancers, however, its roles plasma of hepatocellular carcinoma HCC ) patients were unclear. The aim this study to investigate the significance levels patients. Plasma samples collected from pre‐operative , hepatic disease patients, and healthy controls, tissue colorectal cancer with liver metastasis. measured. progressively significantly higher than controls....
BackgroundCytokines have validated roles in the immunopathogenesis of inflammatory bowel disease (IBD). This study was to investigate expressions tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, and IL-10 mRNAs colonic mucosa patients with ulcerative colitis (UC) during active quiescent UC.
Peritoneal metastasis consists of a highly complex series steps, and the details underlying molecular mechanism remain largely unclear. In this study, effects tumor-derived exosomes (TEX) on progression gastric cancers were investigated in peritoneal metastasis.TEX internalized both mesothelial cancer cells cellular origin non-specific manner. Internalization TEX into promoted significant adhesion between cells, internalization significantly migratory ability, while cell-derived did not....
Recent comprehensive molecular subtyping of gastric cancer (GC) identified Epstein-Barr virus (EBV)-positive tumors as a subtype with distinct salient and clinical features. In this study, we aimed to determine the potential utility circulating cell-free EBV DNA biomarker for detection and/or monitoring therapeutic response in patients EBV-associated carcinoma (EBVaGC). The genes-to-ribonuclease P RNA component H1 ratios (EBV ratios) GC plasma samples were determined by quantitative...
We aimed to identify the risk factors for severe neutropenia in early phase of trifluridine-tipiracil (FTD/TPI) treatment, and their impact on overall survival (OS). This single-center retrospective study included patients with unresectable metastatic colorectal cancer who were treated FTD/TPI. The primary endpoint was OS, secondary during first second cycles assessed association between outcomes potential confounders using multivariate analysis. Of 77 total patients, 33 developed treatment...
// Junichi Hamada 1, 2, * , Katsutoshi Shoda Kiyoshi Masuda Yuji Fujita 2 Takuya Naruto 1 Tomohiro Kohmoto 3 Yuko Miyakami Miki Watanabe Yasusei Kudo 4 Hitoshi Fujiwara Daisuke Ichikawa Eigo Otsuji Issei Imoto Department of Human Genetics, Institute Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan Division Digestive Surgery, Kyoto Prefectural Medicine, Kyoto, 602-8566, Student Lab, Faculty Oral Molecular Pathology, These authors contributed equally to...
KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions different tissues and can have an impact on various pathological conditions. In the present study, we investigated oncogenic KHSRP their underlying mechanisms pathogenesis esophageal squamous carcinoma (ESCC). expression levels were elevated ESCC tumors when...
The relationship between autoimmune pancreatitis (AIP) and malignancy has been reported. However, the potential risk for cancer in patients with immunoglobulin 4 (IgG4)-related sclerosing cholangitis (IgG4-SC) is unclear. present study aimed to evaluate incidence of IgG4-SC patients.We retrospectively collected clinical data 121 diagnosed from 7 hospitals. We calculated standardized ratio (SIR) based on national rates. SIR period after diagnosis were calculated.The mean follow-up was 6.4...
The risk and prognosis of pancreatobiliary cancer in patients with autoimmune pancreatitis (AIP) IgG4-related sclerosing cholangitis (IgG4-SC) remain unclear. Therefore, we retrospectively investigated the AIP IgG4-SC.
Extracellular matrices (ECM) are utilized for obtaining better cell attachment to polymer surfaces in cultures. To establish beneficial bioartificial renal tubules, tubular epithelial cells and ECM were investigated this study. MDCK KU‐2 seeded onto 96 well plates which had been precoated with collagen types I IV, laminin, fibronectin. The culture media removed replaced new ones at 15, 30, 60, 90, 120, 150 min 24 h after start time evaluate the incubation effects. degrees of measured by MTT...
The function of current hemodialysis as an artificial kidney is insufficient because the lack reabsorptive function. In this study, we intend to develop a bioartificial renal tubule cell device (RTD) using tubular epithelial cells and membranes evaluate confluent layers. Madin-Darby canine (MDCK) were cultured on nucleopore polycarbonate membrane for up 4 weeks after confluence examine influence culture period their ability transport Na+ actively Na+/K+ATPase (NKA). results (1) active...
Our aim was to develop bioartificial tubules using tubular epithelial cells and artificial membranes evaluate the function of water electrolyte transport by various cells. The were cultivated onto extracellular matrix (ProNectin F) coating polycarbonate membrane. Water from apical basolateral site examined a modified Ussing chamber module. under colloidal osmotic pressure on hydraulic higher in JTC-12, LLC-PK1 than MDCK plus highest We made polysulfone hollow fiber cartridges. Na ion high,...
We investigated a portable bioartificial renal tubule device (BRTD) consisting of cells and hollow fibers, to improve the quality life patients. It is necessary for BRTD system be compact. A compact BRTB requires transfection an appropriate water channel or electrical pump genes in tubular epithelial cells, which should based on physiological similarities human kidney function. LLC-PK 1 into rat aquaporin (AQP1) cDNA was stably transfected, were evaluated transport ability. The expression...