The relationship between serum carnitine levels and erythrocyte osmotic fragility was investigated in 26 chronic hemodialysis patients (10 males 16 females, mean age: 57.3 +/- 13.5 years). Serum total-carnitine (TC), free-carnitine (FC) acyl-carnitine (AC) were determined by a spectrophotometric method. Erythrocyte measured with coil planet centrifuge. TC 39.9 13.4 mumol/l (mean SD), FC 21.8 7.8 AC 18.0 9.6 mumol/l. hemolysis end point (HEP) 67.4 5.4 mOsM, the maximum (HMP) 86.3 mOsM start...

Objectives This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN). Methods We studied six IgG4-related TIN patients receiving renal biopsies before and after therapy. Their clinical data histological findings were evaluated Results Elevated serum creatinine levels rapidly improved except for two patients, whom it persisted. Abnormal radiological all although focal cortical atrophy...

Objectives This study aimed to investigate the clinicopathological changes induced by corticosteroid therapy in immunoglobulin (Ig)G4-related tubulointerstitial nephritis (TIN).

Mikulicz's disease (MD) is gaining acceptance as an immunoglobulin G4 (IgG4)-related characterized by bilateral lacrimal and salivary gland swelling. The aetiology of MD other IgG4-related diseases still unclear. present work was performed to study the clonality infiltrating IgG4-positive plasma cells in glands circulating peripheral blood patients with MD, compare clonal relationship between IgG4 positive cells. Total cellular RNA extracted from five patients. Reverse transcription...

We present a case of 47-year-old man with Type 2 diabetes mellitus who attempted suicide 2, 100 U insulin injected subcutaneously. Administration dextrose intravenously was required to maintain the blood glucose concentration normally for 5 days. Moreover, hypokalemia, hypophosphatemia, and hypomagnesemia were also seen 24 hours after injection. The serum phosphorus magnesium concentrations decreased nadirs 1.6 mg/dl respectively 7 Electrolyte disorders other than hypokalemia may be induced...

The influence of angiotensin-converting enzyme inhibitors (ACEIs) on recombinant human erythropoietin (rhEPO) maintenance doses in hemodialysis patients was studied. One hundred and eight chronic (55 males 53 females, mean age 61.2 ± 12.6 years) were investigated. rhEPO the ACEI-treated group (n = 49) 101.7 51.7 U/kg/week nontreated 59) 79.2 37.8 (p < 0.05). No difference observed hematocrit between groups. In stepwise regression analysis, parameters associated with increased female gender,...

We describe a 64-year-old woman with chronic sclerosing sialadenitis and dacryoadenitis, which developed during treatment for cervical lymph node tuberculosis. Anti-tuberculosis did not improve the swelling in lacrimal submandibular glands, biopsy specimen of gland showed inflammation, abundant lymphoid follicles fibrosis granuloma without caseous necrosis. Immunohistological examination repeat immunoglobulin (Ig) G4-positive plasma cell infiltration. Corticosteroid therapy improved salivary...

We report a case of Henoch- Schönlein purpura nephritis (HSPN) associated with tubulointerstitial (TIN) and chronic sclerosing sialoadenitis. The patient is 75-year-old Japanese woman who had bilateral submandibular gland swelling, palpable on the lower legs, decreased renal function hematoproteinuria marked hypocomplementemia, but no skin lesion suggestive systemic lupus erythematosus (SLE), did not fulfill classification criteria for SLE. Her serum IgG4 level was high immunostaining...

We describe a 60-year-old man with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis associated lymphoplasmacytic eosinophilic infiltration in erythematous nodules. Physical examination revealed left eye extrusion small itchy nodules on the scalp neck. The serum IgG level was 1,570 mg/dL, IgG4 463 mg/dL (29.5%), IgE 4,554 IU/mL. Lacrimal gland biopsy disclosed prominent infiltrates of IgG4-positive plasma cells scattered fibrosis, consistent disease. A skin cutaneous nodule...

We report a case of pseudo-renal failure caused by urinary ascites due to spontaneous bladder rupture following transurethral resection tumour (TUR-BT). A 63-year-old man presented with 2 months abdominal distension ascites. Laboratory findings showed elevated serum creatinine and hyperkalaemia. Peritoneal fluid urea, potassium levels were greater than those in levels. CT scan partial wall thinning the wall, cystography indicated fragility dome where latest TUR-BT was performed. Pseudo-renal...

We describe a 64-year-old woman with chronic sclerosing sialadenitis and dacryoadenitis, which developed during treatment for cervical lymph node tuberculosis. Anti-tuberculosis did not improve the swelling in lacrimal submandibular glands, biopsy specimen of gland showed inflammation, abundant lymphoid follicles fibrosis granuloma without caseous necrosis. Immunohistological examination repeat immunoglobulin (Ig) G4-positive plasma cell infiltration. Corticosteroid therapy improved salivary...

Immunoglobulin G4 (IgG4)-related tubulointerstitial nephritis (TIN) is often accompanied by autoimmune pancreatitis (AIP) or chronic sclerosing dacryoadenitis and sialoadenitis. However, IgG4-related TIN without AIP lacrimal and/or salivary gland lesions has not been well recognized. Here, we report a case of associated with hepatic inflammatory pseudotumor lesions. A 58-year-old Japanese man epigastralgia underwent contrast-enhanced computed tomography (CT), which revealed multiple...

We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) hepatitis B virus (HBV) carrier status who was successfully treated tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. administered etanercept because of the occurrence repeated flares despite aggressive therapy. C-reactive protein normalization; prednisolone dose-sparing; absence any adverse events, including HBV reactivation nucleotide analogue administration, or renal...

An 88-year-old woman presented with a 2-month history of recurrent episodes acute pain in her neck and knees that were associated fevers 38 to 39.3°C. She reported no visual symptoms, jaw claudication, morning stiffness, or the upper arms shoulders. Radiography revealed chondrocalcinosis stippled calcifications pubic symphysis. Computed tomography showed curvilinear transverse ligament atlas (Panel A, arrows), linear calcification B, crown-shaped calcium deposits surrounding odontoid process...

Abstract Background Following community clinical placements, medical students use reflective writing to discover the story of their journey becoming professionals. However, because assessor bias analyzing these writings qualitatively generalize learner experiences may be problematic. This study uses a process-oriented text mining approach better understand meanings by connecting key concepts in extended student essays. Methods Text quantitative analysis is used on self-evaluative essays ( n...

Abstract Background Developing self-regulated learning in preclinical settings is important for future lifelong learning. Previous studies indicate professional identity formation, i.e., formation of self-identity with internalized values and norms professionalism, might promote We designed a formation-oriented reflection plan format, then tested effectiveness on raising year curriculum. Methods A randomized controlled crossover trial was conducted using 112 students at Jichi Medical...

A mitochondrial 3243 G mutation in the tRNA(Leu(UUR)) gene was first described as a common cause of MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like syndrome). This same is also totally different disorder, subtype diabetes mellitus which inherited maternally often associated with sensorineural hearing loss. In this paper, we report on Japanese boy who developed previously undescribed combination symptoms, nephropathy growth hormone deficiency. The...

We describe a 74-year-old Japanese man with systemic fibroinflammatory conditions closely resembling those of immunoglobulin G4-related disease (IgG4-RD). Radiology and histology showed characteristics IgG4-related tubulointerstitial nephritis, despite normal serum IgG4 value scanty IgG4-positive plasma cell infiltration in each organ. This case suggests that condition mimicking IgG4-RD may develop without cells exceptional cases should also be taken into account the differential diagnosis IgG4-RD.

A 56-year-old man presented to our department with a 2-month history of fever and chills. He had received mitral valvuloplasty 3 years ago. been administered levofloxacin for 2 months. We discontinued repeated the blood cultures. Bacterial cultures were positive transoesophageal echocardiography revealed vegetation attached posterior leaflet. started patient on intravenous antibiotic therapy infectious endocarditis by Streptococcus gallolyticus subspecies pasteurianus. colonoscopic screening...

Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is encephalopathy caused by various pathological processes, but due to bacteria rare. We report the case of 45-year-old Japanese woman who on receiving chemotherapy for advanced breast cancer developed an altered mental status and dysarthria soon after fever from infection subcutaneous implantable port. Staphylococcus aureus was detected in her blood cultures. Magnetic resonance imaging (MRI) revealed ovoid...

Angioedema associated with angiotensin converting enzyme inhibitors is a rare adverse reaction. It commonly involves the face, oropharyngeal and laryngeal tissues. To our knowledge, angioedema of abdominal viscera related to has not been reported previously. We present case patient who had episodes pain ascites probably ACE inhibitor captopril.(Internal Medicine 32: 424-426, 1993)

We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) hepatitis B virus (HBV) carrier status who was successfully treated tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. administered etanercept because of the occurrence repeated flares despite aggressive therapy. C-reactive protein normalization; prednisolone dose-sparing; absence any adverse events, including HBV reactivation nucleotide analogue administration, or renal...