A5006803287- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Synthesis and properties of polymers
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Parkinson's Disease Mechanisms and Treatments
- Diabetes and associated disorders
- Neurological Disorders and Treatments
- Semiconductor materials and devices
- Liquid Crystal Research Advancements
- Epoxy Resin Curing Processes
- Diabetes Treatment and Management
- Photochemistry and Electron Transfer Studies
- Advanced Glycation End Products research
- Molecular spectroscopy and chirality
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Electrochemical Analysis and Applications
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Health and Disease Prevention
- Mitochondrial Function and Pathology
- Corrosion Behavior and Inhibition
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Miyagi Children's Hospital
2024
Wakayama Medical University
2012-2021
Miyagi University
2020
Wakayama University
1995-2019
Suntory Foundation for Life Sciences
2019
Kihoku hospital
2015-2018
Johns Hopkins Medicine
2017
Johns Hopkins University
2017
Toshiba (Japan)
1991-2015
Industrial Research Institute
1983-2015
Atherosclerosis in type 2 diabetic patients has been linked to increased oxidative stress. Glutathione peroxidase-1 (GPx-1) plays an important role the antioxidant defense of vascular wall. To assess association between variants GPx-1 gene and atherosclerosis, we screened 184 Japanese identified four polymorphisms (−602A/G, +2C/T, Ala5/Ala6, Pro198Leu). Among these polymorphisms, −602G, +2T, Ala6, 198Leu were strong linkage disequilibrium with each other. The divided into two groups on basis...
Antioxidant activity and biological properties of ferulic acid (FA) are well recognized. This study was designed to estimate the potential utility FA administered orally at low dosage for improvement hyperglycemia in diabetes. With this aim we have evaluated hypoglycemic effect two type diabetic animal models: (1) streptozotocin (STZ)-induced mice, a model insulin-dependent diabetes mellitus (IDDM); (2) KK-Ay non-insulin dependent (NIDDM). In addition, measured production thiobarbituric...
OBJECTIVE Our goal was to ascertain the prevalence of pruritus in diabetic and nondiabetic subjects relevance symptoms, signs, nerve functions polyneuropathy (DPN) pruritus. RESEARCH DESIGN AND METHODS A large-scale survey 2,656 outpatients 499 performed. In subjects, relationship between age, sex, duration, A1C, Achilles tendon reflex (ATR), abnormal sensation legs evaluated. 105 conduction studies, quantitative vibratory threshold (QVT), heart rate variability, a fall systolic blood...
Common uncoupling protein 2 (UCP2) promoter polymorphism −866G/A is reported to be associated with its expression in adipose tissue and the risk of obesity Caucasians. On other hand, several studies suggested that UCP2 β-cells an important determinant insulin secretion. In Japanese population, morbid very rare, secretion capacity relatively low as compared Because would link obesity, it might explain this ethnic difference. Here, we report A allele showed higher activity INS-1 β-cell line....
Reactive oxygen species (ROS) derived from NADPH oxidase (Nox) homologues have been suggested to regulate osteoclast differentiation. However, no bone abnormalities documented in Nox1 deficient, Nox2 or Nox3 mutant mice. During receptor activator of nuclear factor-κB ligand (RANKL)-stimulated differentiation a mouse macrophage cell line (RAW264.7) into osteoclasts, mRNA levels Nox enzymes (Nox1-4) and their adaptor proteins were monitored by real-time reverse transcriptase PCR. RAW264.7...
Ghrelin is a newly discovered peptide and an endogenous ligand for growth hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various central peripheral effects, including GH secretion, food intake, gastric cardiac effects. the GHS receptor are expressed also in pancreatic islets. We have identified several ghrelin-induced genes by PCR-select subtraction methods, among which β-cell autoantigen type 1 diabetes, IA-2β. Administration of ghrelin increased IA-2β mRNA mouse...
Ghrelin inhibits insulin secretion partly via induction of IA-2beta. However, the orexigenic effect ghrelin is mediated by AMP-activated protein kinase (AMPK)-uncoupling 2 (UCP2) pathway. Here, we demonstrate that ghrelin's inhibitory on also occurs through AMPK-UCP2 increased AMPK phosphorylation and UCP2 mRNA expression in MIN6 insulinoma cells. Overexpression or downregulation attenuated enhanced secretion, respectively. Furthermore, activator had a similar to In conclusion, pathway,...
Immunoglobulin G4-related disease (IgG4-RD) is a new clinical entity that affects various organs with increased IgG4 positive plasmacytes and progressive fibrosis. While IgG4-RDs in association Hashimoto's thyroiditis or Riedel's have been reported, the relationship between IgG4-RD Graves' (GD) yet unknown. To elucidate relation of GD to IgG4-RD, serum levels their implications patients were investigated.In this prospective study, measured 109 classified into two groups according...
Abstract Context: A genome-wide association study in the French population has detected that novel single-nucleotide polymorphisms (SNPs) IDE-KIF11-HHEX gene locus and SLC30A8 are associated with susceptibility to type 2 diabetes. Objective: We investigated whether SNPs these loci were diabetes Japanese. Design: Two SNPs, rs7923837 rs1111875, one SNP, rs13266634, genotyped Japanese diabetic patients (n = 405) nondiabetic control subjects 340) using TaqMan genotyping assay system. Results:...
Mutations in transcription factors expressed the pancreatic β-cell are a major cause of maturity-onset diabetes young (MODY). They have also been found patients diagnosed with type 1 and 2 mellitus, which may highlight difficulty diagnosing these forms or perhaps indicate direct role development multiple diabetes. We screened hepatocyte nuclear factor-1β (HNF-1β/MODY5) gene for mutations group 126 unrelated Japanese family history at least one first degree relative identified patient...
Abstract Background Paired box gene 6 (PAX6) is a transcription factor involved in eye development. Mutations of PAX6 cause congenital anomalies, such as aniridia. also the development endocrine pancreas, and reported to be genetic common aniridia glucose intolerance, although latter usually mild. Here, we describe case mutation with early‐onset diabetes mellitus. Case report A 27‐year‐old woman was referred our clinic. She diagnosed having at age 15 negative glutamic acid decarboxylase...
This report describes a 37-year-old man with tumor-induced osteomalacia (TIO). The patient had hypophosphatemia and elevated fibroblast growth factor 23 (FGF23) in the peripheral blood. Magnetic resonance imaging detected an abnormal mass left greater trochanter. Venous sampling revealed significantly higher level of FGF23 common iliac vein (proximal to tumor), verifying that tumor is responsible for TIO. serum decreased symptoms improved after removal tumor. combined diagnostic procedures...
This is the English version of guidelines for diagnosis and treatment idiopathic portal hypertension, extrahepatic obstruction, Budd-Chiari syndrome, which were established revised in 2018 by Aberrant Portal Hemodynamics Study Group under jurisdiction Ministry Health, Labor, Welfare Japan. These are excerpts, full consists 86 clinical questions explanations, totaling 183 pages Japanese.