A5074981902- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Chemical Sensor Technologies
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Microtubule and mitosis dynamics
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cellular transport and secretion
- Circadian rhythm and melatonin
- Sphingolipid Metabolism and Signaling
- Lysosomal Storage Disorders Research
- Bladder and Urothelial Cancer Treatments
- Pain Mechanisms and Treatments
- Sperm and Testicular Function
- Neural dynamics and brain function
- Barrier Structure and Function Studies
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
Kawasaki Medical School
2013-2024
Osaka University
2016-2024
Tokushima University
1999-2014
Institute of Cell Biology and Neurobiology
2006
Kyushu University
1994-2001
Abstract Objective: Causative viruses of postviral olfactory dysfunction (PVOD) have not yet been identified. The aim this study was to investigate causative in patients with PVOD. Study Design and Methods: Nasal discharge collected from 24 We investigated the presence 10 nasal examined time course, regard changes obstruction PVOD, using questionnaires, acoustic rhinometry, tests. Results: Rhinoviruses were detected by electrophoresis. also confirmed four nucleotide sequences. Viral...
Within glomeruli, the initial sites of synaptic integration in olfactory pathway, sensory axons terminate on dendrites projection and juxtaglomerular (JG) neurons. JG cells form at least two major circuits: classic intraglomerular circuit consisting external tufted (ET) periglomerular (PG) an interglomerular comprised long-range connections short axon (SA) cells. We examined projections inputs identified cell chemotypes using mice expressing green fluorescent protein (GFP) driven by promoter...
New cells are continuously added to the rodent olfactory bulb (OB), throughout development and in adults. These migrate tangentially from subventricular zone along rostral migratory stream OB, where they radically center periphery of OB. Although different modalities radial migration have been described other brain regions, mechanisms governing OB still mostly unknown. Here, we identify a new modality which neuronal precursors blood vessels toward their destination. Our results show that...
Accumulating evidence implicates the significance of physical properties niche in influencing behavior, growth and differentiation stem cells. Among properties, extracellular stiffness has been shown to have direct effects on fate determination several cell types vitro. However, little exists concerning whether shifts occur vivo during tissue development. To address this question, we present a systematic strategy evaluate shift developing using mouse embryonic cerebral cortex as an...
Rab3A small G protein is a member of the Rab family and most abundant in brain, where it localized on synaptic vesicles. Evidence accumulating that plays key role neurotransmitter release plasticity. cycles between GDP-bound inactive GTP-bound active forms, this change activity associated with trafficking cycle vesicles at nerve terminals. Rab3 GTPase-activating (GAP) stimulates GTPase expected to determine timing dissociation from vesicles, which may be coupled vesicle exocytosis. GAP...
Odor information is regulated by olfactory inputs, bulbar interneurons, and centrifugal inputs in the bulb (OB). Cholinergic neurons projecting from nucleus of horizontal limb diagonal band Broca magnocellular preoptic are one primary to OB. In this study, we focused on cholinergic regulation OB analyzed neural morphology with a particular emphasis projection pathways neurons. Single-cell imaging specific neuron within dense fibers critical evaluate structure function circuits. We labeled...
The sphingolipid activator proteins (saposins A, B, C and D) are small homologous glycoproteins that encoded by a single gene in tandem within large precursor protein (prosaposin) required for vivo degradation of some sphingolipids with relatively short carbohydrate chains. Human patients prosaposin or specific saposin B deficiency known, prosaposin- A-deficient mouse lines have been generated. Experimental evidence suggests D may be lysosomal acid ceramidase activator. However, no state is...
Azoospermia and oligospermia are major causes of male infertility. Some genes located on the Y chromosome suggested as candidates. Recently, HSFY, which is similar to HSF (heat shock transcription factor) family, has been mapped human multicopies. However, newly available sequence data deposited at NCBI shows that only HSFY gene Yq a long open reading frame containing HSF-type DNA-binding domain. LW-1 X murine HSFY-like (mHSFYL), 4933413G11Rik, mouse 1. mHSFYL have 53% 70% homology for amino...
Olfactory processing is well known to be regulated by centrifugal afferents from other brain regions, such as noradrenergic, acetylcholinergic, and serotonergic neurons. Serotonergic neurons widely innervate regulate the functions of various regions. In present study, we focused on regulation olfactory bulb (OB), one most structurally functionally well-defined Visualization a single neuron among abundant dense fibers essential characterize understand neuronal circuits. We accomplished this...
The present study analyzed three-dimensional structural features and synaptic contacts of morphologically chemically identified calbindin D28K-immunoreactive neurons in the glomerular layer rat main olfactory bulb by means combined confocal laser scanning light microscopy, high-voltage electron microscopy microscopic serial section/three-dimensional reconstruction. Most were as periglomerular cell type observations, minority short-axon others. revealed that exhibited unique contact patterns;...
Angiotensin II (Ang II) plays an important role in several cardiovascular diseases associated with vascular smooth muscle cell (VSMC) growth and migration. Src activity is known to be required for the migration of a number types. p130Cas was reported essential actin filament reorganization. Mitogen-activated protein (MAP) kinases were also critical regulatory factors VSMC. However, precise intracellular mechanisms involving c-Src, p130Cas, MAP Ang II-stimulated VSMC have not been well...
To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear renal carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate prognostic value for patient outcome, determine effect PSCA on progression CC-RCC.We quantified mRNA RCC lines (ACHN, A704, KPK-1, Caki-1, Caki-2) 154 surgical tissue samples (81 from CC-RCC, 73 normal kidney) using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The...