A5048772276- Pancreatitis Pathology and Treatment
- Metastasis and carcinoma case studies
- Chronic Kidney Disease and Diabetes
- Digital Imaging for Blood Diseases
- Renal Diseases and Glomerulopathies
- AI in cancer detection
- Vascular anomalies and interventions
- Peripheral Artery Disease Management
- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Intestinal Malrotation and Obstruction Disorders
- Diabetes Treatment and Management
- Gallbladder and Bile Duct Disorders
- Medical Image Segmentation Techniques
- Total Knee Arthroplasty Outcomes
- Cardiovascular Health and Disease Prevention
- Genetic and Kidney Cyst Diseases
- Gastrointestinal Tumor Research and Treatment
- RNA Research and Splicing
- Orthopaedic implants and arthroplasty
- Pancreatic and Hepatic Oncology Research
Mitsubishi Tanabe Pharma Corporation
2010-2023
Wakayama Rosai Hospital
2005-2018
Mitsubishi Group (Japan)
2017
Janssen (United States)
2014
Showa University Northern Yokohama Hospital
2011-2012
Kyoto University
2004-2011
Wakayama Medical University
2008
Glomerulus detection is a key step in histopathological evaluation of microscopy images kidneys. However, the task automatic glomeruli poses challenges due to disparity sizes and shapes renal sections. Moreover, extensive variations their intensities heterogeneity immunohistochemistry staining are also encountered. Despite being widely recognized as powerful descriptor for general object detection, rectangular histogram oriented gradients (Rectangular HOG) suffers from many false positives...
In evaluating pathological changes in drug efficacy and toxicity studies, morphometric analysis can be quite robust. this experiment, we examined whether of major findings various tissue specimens stained with hematoxylin eosin could recognized quantified using image processing software. Using Tissue Studio, hypertrophy hepatocytes adrenocortical cells based on the method a previous report, but regions red pulp, white marginal zones spleen not when one setting condition. Image-Pro Plus,...
Diabetic nephropathy is a major complication in diabetes and leading cause of end-stage renal failure. Glomerular podocytes are functionally structurally injured early diabetic nephropathy. A non-obese type 2 model, the spontaneously Torii (SDT) rat, increasing preclinical interest because its pathophysiological similarities to human complications including However, podocyte injury SDT rat glomeruli effect angiotensin II receptor blocker treatment stage have not been reported detail....
Sodium–glucose cotransporter 2 (SGLT2) plays a major role in renal glucose reabsorption. To analyze the potential of insulin-independent blood control, effects novel SGLT2 inhibitor canagliflozin on reabsorption and progression hyperglycemia were analyzed Zucker diabetic fatty (ZDF) rats. The transporter activity recombinant human rat was inhibited by canagliflozin, with 150- to 12,000-fold selectivity over other transporters. Moreover, vivo treatment induced glucosuria mice, rats, dogs...
Actin reorganization is important for regulation of neuronal morphology. Neural Wiskott-Aldrich syndrome protein (N-WASP) an regulator actin polymerization and also known to be strongly expressed in brain. Recently, Toca-1 (transducer Cdc42-dependent assembly) has been shown required Cdc42 activate N-WASP from biochemical experiments. three functional domains: F-BAR/EFC domain at the N terminus, HR1 center, SH3 C terminus. The induces tubular invagination plasma membrane, while binds both...
Renal fibrosis is the major cause of chronic kidney disease, and Rho/Rho-associated coiled-coil kinase (ROCK) signaling cascade involved in renal fibrotic processes. Several studies have reported that ROCK inhibitors attenuate fibrosis. However, mechanism this process remains to be fully elucidated. The present study assessed inhibitory effect fasudil, a inhibitor using immunohistochemistry, reverse transcription-quantitative polymerase chain reaction western blot analyses, vivo vitro,...
This report describes a 37-year-old man with tumor-induced osteomalacia (TIO). The patient had hypophosphatemia and elevated fibroblast growth factor 23 (FGF23) in the peripheral blood. Magnetic resonance imaging detected an abnormal mass left greater trochanter. Venous sampling revealed significantly higher level of FGF23 common iliac vein (proximal to tumor), verifying that tumor is responsible for TIO. serum decreased symptoms improved after removal tumor. combined diagnostic procedures...
Background/Aims . Recent evidence has suggested that appendix plays a pivotal role in the development and preservation of intestinal immune system. The aim this study is to examine whether prior appendectomy associated with an increased risk for antibiotic-resistant bacteria bacteremia from biliary tract infection (BTI). Methods Charts 174 consecutive cases derived BTI were retrospectively reviewed. Using multivariate analysis, independent factors identified among clinical parameters,...
Rho family GTPases regulate neuronal morphology. Rnd subfamily is a new branch of GTPases. Of these GTPases, Rnd2 specifically expressed in brain. We recently identified Rapostlin as novel effector Rnd2. induces neurite branching response to PC12 cells. During the cloning Rapostlin, we have found two mainly splicing variants (renamed RapostlinL), RapostlinM and RapostlinS, lacking 29 residues 61 within unique insert region at center, respectively, three minor variants, RapostlinLd,...
Type 2 diabetes is characterized by impaired insulin secretion from pancreatic β-cells. Quantification of the islet area in addition to insulin-positive important for detailed understanding histopathology. Here we show computerized automatic recognition islets Langerhans as a novel high-throughput method quantify We utilized state-of-the-art tissue pattern software enable islets, eliminating need laboriously trace borders hand. After training histologist, successfully recognized even...
Pombe Cdc15 homology proteins, characterized by Fer/CIP4 Bin-Amphiphysin-Rvs/extended (F-BAR/EFC) domains with membrane invaginating property, play critical roles in a variety of reorganization processes. Among them, Rapostlin/formin-binding protein 17 (FBP17) has attracted increasing attention as coordinator endocytosis. Here we found that Rapostlin was expressed the developing rat brain, including hippocampus, late developmental stages when accelerated dendritic spine formation and...
Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P 1 ) modulator with more favorable cardiac safety profile than other S1P receptor modulators. In this study, we evaluated the effects of MT-1303 on progression lupus nephritis in two well-known murine systemic erythematosus (SLE) models, MRL/ lpr NZBWF1 mice, compared those FK506. Daily oral doses 0.1 0.3 mg/kg not only inhibited development when administered before onset mice but also improved symptoms...
Abstract Background and study aims Re-commencement of bleeding (rebleeding) colonic diverticula after endoscopic hemostasis is a clinical problem. This aimed to examine whether visibility diverticular affects the risk rebleeding hemostasis. Patients methods We performed retrospective review images medical charts patients with who underwent Endoscopic was classified into two types according source bleeding; invisibility due or attached hematin (type 1), endoscopically visible responsive...
Facioscapulohumeral muscular dystrophy (FSHD), one of the most common dystrophies, is caused by an abnormal expression DUX4 gene in skeletal muscles, resulting muscle weakness. In this study, we investigated MT-DUX4-ASO, a novel gapmer antisense oligonucleotide (ASO). MT-DUX4-ASO decreased and its target genes FSHD patient-derived myoblasts. For first time, demonstrated that systemically administered ASO, even without ligand for drug delivery, could significantly improve injury motor...
Objective Superior mesenteric artery (SMA) syndrome is characterized by the compression of third segment duodenum between SMA and aorta, resulting in duodenal obstruction. Because symptoms are similar to those functional dyspepsia (FD), this study aimed examine whether or not patients with were present among diagnosed FD. Methods Patients an FD diagnosis underwent measurement angle distance aorta ultrasonography computed tomography. ≤22° a ≤8 mm syndrome. Bacterial culture aspirate was also...
Urinary nano-extracellular vesicles (NVs), including exosomes and microvesicles, are considered potential biomarkers for kidney diseases using liquid biopsies. However, clinical application of urinary NVs has not yet been validated. In the present study, levels mRNAs in animal models disease were assessed. Urine samples collected from isolated by ultracentrifugation. Gene expression injury markers renal tissue quantified reverse transcription-quantitative PCR. The mRNA desmin, a podocyte...
55歳,女性. 2002年7月進行型小細胞肺癌の診断のもとに,全身化学療法を行い, partial response (PR)を得た.しかし平成15年1月多発性脳転移にて再燃再入院した.全脳照射,メソトレキセート(MTX)の髄空内投与を行ったところ,汎血球減少をきたした.その原因として,全脳照射, MTXの髄腔内投与, disseminated intravascular coagulation (DIC)の関与等も想定されたが,骨髄所見より血球貪食症候群が原因と診断した.二次性の血球貪食症候群としては,感染症・悪性腫瘍・自己免疫等が報告されているが,悪性腫瘍,なかでも肺癌に伴うものは少ないため報告する.