A5015212857- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Pain Management and Opioid Use
- Colorectal Cancer Treatments and Studies
- Pain Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Epilepsy research and treatment
- Connexins and lens biology
- Semiconductor materials and devices
- Vitamin K Research Studies
- Lung Cancer Treatments and Mutations
- Hemoglobinopathies and Related Disorders
- Gastric Cancer Management and Outcomes
- Barrier Structure and Function Studies
- Prenatal Substance Exposure Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- HIV/AIDS drug development and treatment
- Blood transfusion and management
- Metal and Thin Film Mechanics
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacology and Obesity Treatment
- Botulinum Toxin and Related Neurological Disorders
Kanazawa University
2018-2024
Kanazawa University Hospital
2021-2024
Keio University
2022-2023
Abstract Background Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a CLAM-LC-MS/MS system, which consists of sample preparation module directly connected LC-MS/MS, could be used for clinical TDM work immunosuppressive drugs in whole blood, requires hemolytic process. For purpose, prospectively validated system...
Multidrug resistance protein 1 (MDR1) is located at the interface between two syncytiotrophoblast layers in rodent placenta, and may influence fetal drug distribution. Here, we quantitatively compare functional impact per single MDR1 molecule of placental barrier blood-brain mice.MDR1A MDR1B proteins were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Paclitaxel or digoxin was continuously administered to pregnant Mdr1a-/-/Mdr1b-/- wild-type mice, concentrations...
Ceftriaxone (CRO) is a long-acting third-generation cephalosporin antibiotic. We present case of CRO-induced encephalopathy in an 84-year-old male patient with solitary right kidney, admitted bilateral pneumonia and pyelonephritis. Intravenous CRO (2 g, every 24 hours) was started for the infection, but tonic-clonic seizures left face upper extremity appeared on eighth day. To examine relationship between administration seizures, we measured concentrations patients' plasma/serum...
A retrospective study and an animal were conducted to investigate factors affecting the transdermal fentanyl dose achieve adequate pain relief in patients switched from other opioids. In study, patient included as gender, age, body mass index (BMI), serum albumin concentration. obese (BMI ≥25) patients, post-titration of was significantly lower than normal 18.5-25) despite initial same. To support this unexpected finding, administered intravenously transdermally Zucker (fa/fa) rats model...
Abstract Background In the dose titration of transdermal fentanyl to prevent unrelieved pain, it is important consider not only adjustment, but also period, which influenced by time required reach steady state. Many patients with cancer pain experience comorbidities that might affect skin properties and influence absorption. We hypothesized changes due diabetes mellitus (DM) would period fentanyl. conducted a retrospective study diabetic animal model test this hypothesis. Methods study, was...
Background: Vancomycin has a narrow therapeutic window, and an increase in its serum concentration-to-dose ratio during treatment can cause renal toxicity. Therefore, this study was aimed at finding marker to identify patients risk of increasing vancomycin treatment. Methods: This retrospective cohort treated with Kanazawa University Hospital, Japan, from April 2012 May 2015. Spearman correlation coefficients were calculated determine the correlations between changes initial values or...
Breast cancer resistance protein (BCRP) is expressed by brain capillary endothelial cells and at the interface between two placental syncytiotrophoblast layers in rodents serves to suppress drug distribution fetus. The purpose of present study determine compare apparent impact a single BCRP molecule on transfer maternal blood-brain barrier pregnant mice different gestation ages. was quantified liquid chromatography-tandem mass spectrometry. Genistein or dantrolene continuously administered...
Abstract Background Gefitinib and erlotinib, are epidermal growth factor receptor tyrosine kinase inhibitors, currently recommended for non-small cell lung cancer stage IV in the elderly patients with decreased performance status Japanese Lung Cancer Society Guideline, but they occasionally caused severe hepatotoxicity requiring postponement or modification of treatment. However, little is known about risk factors receiving gefitinib erlotinib. In this study, we investigated influencing...
Abstract Background High-flow continuous hemodiafiltration (HF-CHDF) combines diffusive and convective solute removal is employed for artificial liver adjuvant therapy. However, there no report on dosage planning of vancomycin (VCM) in patients with acute failure under HF-CHDF. Case presentation A 20-year-old woman (154 cm tall, weighing 50 kg) was transferred to the intensive care unit (ICU) associated autoimmune disease. On following day, HF-CHDF started due elevated plasma ammonia...