A5054040703- Animal Virus Infections Studies
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
- Cytomegalovirus and herpesvirus research
- Dialysis and Renal Disease Management
- Amino Acid Enzymes and Metabolism
- Chronic Kidney Disease and Diabetes
- Virology and Viral Diseases
- Renal Diseases and Glomerulopathies
- Viral Infectious Diseases and Gene Expression in Insects
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Vasculitis and related conditions
- Medical Imaging and Pathology Studies
- Clostridium difficile and Clostridium perfringens research
- Systemic Lupus Erythematosus Research
- Head and Neck Cancer Studies
- Respiratory viral infections research
- Head and Neck Surgical Oncology
- Viral gastroenteritis research and epidemiology
- Reproductive Health and Contraception
- Sarcoidosis and Beryllium Toxicity Research
- Physical Activity and Health
- Telomeres, Telomerase, and Senescence
- Sodium Intake and Health
Kanazawa University
1985-2025
Kanazawa University Hospital
2020-2023
Okayama University
1978-1996
Institut de Biologie Moléculaire et Cellulaire
1993
Cancer Institute (WIA)
1990-1992
The Cancer Institute Hospital
1986
Justus-Liebig-Universität Gießen
1976-1977
Significance Statement Intestinal barrier dysfunction—a “leaky gut”—reportedly contributes to pathological processes in some diseases. In a mouse model, the authors induced diabetic kidney disease, leading impaired intestinal integrity and inflammation, with IL-17 upregulation. This allowed intestine-derived Klebsiella oxytoca elevated translocate circulation kidneys, then accelerate injury, especially knockout mice lacking mitochondrial antiviral signaling protein (MAVS). Stimulation of...
Recent studies have revealed the connection between amino acid chirality and diseases. We previously reported that gut microbiota produces various d-amino acids in a murine acute kidney injury (AKI) model. Here, we further explored pathophysiological role of d-alanine (d-Ala) AKI. Levels d-Ala were evaluated AKI analyzed transcripts N-methyl-d-aspartate (NMDA) receptor, receptor for d-Ala, tubular epithelial cells (TECs). The therapeutic effect was then assessed vivo vitro. Finally, plasma...
The effect of glucocorticoid hormones on the replication human cytomegalovirus (HCMV) was studied in embryonic lung (HEL) cells. Treatment cells with pharmacological concentrations adrenal glucocorticoids such as dexamethasone enhanced HCMV replication; treatment oestrogenic or androgenic did not do so. In dexamethasone-treated HEL there an approximately tenfold increase virus yield, eclipse period shortened by 1 day compared to control cultures. hormone also plaquing efficiency tenfold. As...
Summary The susceptibility of human central nervous system cell lines to cytomegalovirus (HCMV) and the fate infected cultures were studied. Significant amounts infectious progeny virus produced in 118MGC glioma IMR-32 neuroblastoma, but not KGC oligodendroglioma cells when with wild-type (HCMVwt) at an m.o.i. 10 p.f.u. per cell. Further passage resulted establishment a long-term persistent infection. This infection, designated 118MGC/Towne, continuously (HCMVpi) titres ranging from 102 105...
Abstract Fibroblast accumulation and extracellular matrix (ECM) deposition are common critical steps for the progression of organ fibrosis, but precise molecular mechanisms remain to be fully investigated. We have previously demonstrated that lysophosphatidic acid contributes fibrosis through production connective tissue growth factor (CTGF) via actin cytoskeleton‐dependent signaling, myocardin‐related transcription family (MRTF) consisting MRTF‐A MRTF‐B‐serum response (SRF) pathway. In this...
A 78-year-old man with atherosclerosis was diagnosed hepatocellular carcinoma by transfemoral angiography of the celiac and superior mesenteric arteries (SMA). After surgery, a serum examination revealed progressive renal failure eosinophilia, leading to end-stage kidney disease, in addition active gastric ulcers pancreatitis. Cyanosis bilateral toes showed cholesterol crystal embolism (CCE) skin biopsy. Autopsy that CCE involved arterioles multiple organs, its distribution anatomically...
Electron microscopy observations of purified Bryan high-titer Rous sarcoma virus (BH RSV) using the freeze-drying technique showed that progeny made in absence a helper lacked visible surface projections or spikes. Phenotypic mixing experiments employing BH RSV and thermolabile mutant vesicular stomatitis virus, tl 17, yielded no evidence pseudotype formation. Since 17 is known to be defective for an envelope glycoprotein, lack successful phenotypic with consistent observed viral
A line of chick embryo cells (CEC) was obtained from CEC treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The cells, designated CHCC-OU2, were contact-inhibited, formed no colony in soft agar and did not produce tumors when inoculated into syngeneic chickens. electron microscopic examination reverse transcriptase assay showed virus production the cells. Subgroup avian sarcoma (ASV) Newcastle disease replicated well this cell line.
The revision of International Society Nephrology/Renal Pathology (ISN/RPS) classification guidelines for lupus nephritis (LN) was suggested by a working group, who recommended modified National Institute Health (NIH) activity and chronicity scoring system to evaluate active chronic LN lesions. However, whether this approach useful estimating long-term prognosis patients is unclear.We conducted retrospective cohort study in Japanese subjects with biopsy-proven LN, between 1977 2018....
ABSTRACT The full-length receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor. High-mobility group box 1 (HMGB1) RAGE ligand of damage-associated molecular patterns that elicits inflammatory reactions. shedded isoform and endogenous secretory (esRAGE), splice variant, are soluble isoforms (sRAGE) act as organ-protective decoys. However, the pathophysiologic roles RAGE/sRAGE in acute kidney injury (AKI) remain unclear. We found AKI was more severe,...
Abstract Background Recent studies revealed that lysophospholipids (LPLs) and related molecules, such as autotaxin (ATX) phosphatidylserine‐specific phospholipase A 1 (PS‐PLA ), are candidates for novel biomarkers in melanoma, glaucoma diabetic nephropathy. However, it is not clear whether serum levels of ATX/ PS‐PLA would be associated with pathological clinical findings lupus nephritis (LN). Methods In this retrospective cohort study, samples were collected from 39 patients LN 37 other...
An attempt was made to detect human papillomavirus (HPV) in 8 cases of oral papilloma by Southern blot hybridization. HPV type 6 identified a case tonsillar condyloma acuminatum, but neither nor 11 found the 7 other squamous papilloma. The hybridization pattern DNA after digestion with restriction enzymes revealed that 6f subtype. samples isolated from 3 peripheral specimens clinically normal mucosa, swab sample and saliva male patient this acuminatum were examined further polymerase chain...
Summary Correlation between cytotoxin production and sporulation was demonstrated when a Clostridium difficile culture inoculated into fresh broth to give an initial count of < 10 vegetative cells/ml with no spores. Under these conditions, produced released during sporulation. Addition inhibitor (acridine orange, 30 mg/L), resulted in marked decrease both production, despite there being change the number cells culture. These results indicate that might be closely related production.
Abstract Background Patients with chronic kidney disease (CKD) reportedly show dysbiosis, which is the imbalance of gut microbiome. Dysbiosis increases uremic toxin level in intestine, and toxins transfer into blood, causing CKD progression. Sake lees, a traditional Japanese fermented food, may help reduce by altering Additionally, D-alanine, present sake have renoprotective effect. The pilot study aims to evaluate effect adding lees standard dietary therapy reducing blood toxins. Methods...
Abstract Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed new biological function trehalose as an autophagy inducer. Thus far, reports regarding the therapeutic effects on fibrotic diseases. Therefore, we examined whether has anti-fibrotic PF. PF was induced by intraperitoneal injection chlorhexidine gluconate (CG). CG challenges increase thickness, ColIα 1 mRNA expression and hydroxyproline...
The prevalence of human papillomavirus (HPV) DNA in nasal papillomas was examined by polymerase chain reaction (PCR) and Southern blot hybridisation. HPV 6 one case, 57 case 16 three cases were detected amongst 12 that comprised fungiform exophytic nine inverted papillomas. Five (two papillomas) recurrent four (80.0%) these DNA-positive. remaining seven non-recurrent only (14.3%) This difference detection rates between statistically significant.
The relationship between dietary habits and development of chronic kidney disease (CKD) is unclear. This retrospective cohort study was conducted to examine the association unhealthy proteinuria onset, a key prognostic factor CKD, among Japanese general population aged ≥40 years. risks onset were estimated based on status baseline (quick eating, late dinner, evening snack, skipping breakfast) compared with without these habits. A total 26,764 subjects included, mean follow-up period 3.4 most...
Progression of renal anemia has been shown to be associated with advanced tubulointerstitial lesions. This retrospective study investigated the impact lower hemoglobin (Hb) levels and interstitial fibrosis tubular atrophy (IFTA) on long-term outcomes in type 2 diabetes biopsy-proven diabetic nephropathy.A total 233 patients were enrolled. The severity IFTA was scored according classification by Renal Pathology Society. Patients stratified baseline Hb tertiles status. first occurrence events...