A5102880085- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Erythropoietin and Anemia Treatment
- Kidney Stones and Urolithiasis Treatments
- Antimicrobial Resistance in Staphylococcus
- Renal cell carcinoma treatment
- Urticaria and Related Conditions
- Bacterial biofilms and quorum sensing
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Therapeutic Uses of Natural Elements
- Enzyme Production and Characterization
- Bipolar Disorder and Treatment
- Blood groups and transfusion
- Biochemical and Structural Characterization
- Blood properties and coagulation
- Adolescent and Pediatric Healthcare
- S100 Proteins and Annexins
- Pulmonary Hypertension Research and Treatments
- Microbial Metabolism and Applications
- Connective Tissue Growth Factor Research
- Genetic and Kidney Cyst Diseases
Public Central Hospital of Matto Ishikawa
2023
Kanazawa University
2009-2021
Kanazawa University Hospital
2013-2020
Kanazawa Medical Center
2019
Pediatric Nephrology of Alabama
2018
RELX Group (United States)
2017
Sapporo Toho Hospital
2017
Mizuho (Japan)
2017
Institute of Applied Biochemistry
2004
University of Tsukuba
2004
Gut microbiota-derived metabolites play important roles in health and disease. D-amino acids their L-forms are of gut microbiota with distinct functions. In this study, we show the pathophysiologic role association humans mice acute kidney injury (AKI). a mouse ischemia/reperfusion model, protected against tubular injury. AKI-induced dysbiosis contributed to altered metabolism acids. Among acids, only D-serine was detectable kidney. injured kidneys, activity acid oxidase decreased....
Abstract Peritoneal fibrosis (PF) is a serious complication in various clinical settings, but the mechanisms driving it remain to be fully determined. Connective tissue growth factor (CTGF) known regulate fibroblast activities. We therefore examined if CTGF inhibition has anti-fibrotic effects PF. PF was induced by repetitive intraperitoneal injections of chlorhexidine gluconate (CG) mice with type I pro-collagen promoter-driven green fluorescent protein (GFP) expression identify...
Background Renal coloboma syndrome (RCS) is characterized by renal anomalies and optic nerve colobomas. PAX2 mutations contribute to RCS. However, approximately half of the patients with RCS have no mutation in gene. Methods To investigate incidence effects 25 candidate genes, patient genes were screened using next-generation sequence analysis, confirmed Sanger sequencing. The correlation between clinical manifestation was evaluated. Result Thirty patients, including 26 (two families five...
Dendritic cells (DC) contribute to autoimmune disease progression and pathogenesis. Mature DC have been reported secrete high mobility group box protein (HMGB-1), a novel inflammatory cytokine, via p38 mitogen-activated kinase (MAPK) activation. We investigated whether are involved in of diseases followed by secretion HMGB-1 MAPK activation lupus-prone mouse model.FR167653, specific inhibitor MAPK, was given orally from 3 months age MRL-Fas(lpr) mice. Cultured DC, treated with or without...
Abstract Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed new biological function trehalose as an autophagy inducer. Thus far, reports regarding the therapeutic effects on fibrotic diseases. Therefore, we examined whether has anti-fibrotic PF. PF was induced by intraperitoneal injection chlorhexidine gluconate (CG). CG challenges increase thickness, ColIα 1 mRNA expression and hydroxyproline...
Methicillin-resistant Staphylococcus aureus (MRSA) causes hospital- and community-acquired infections. It is not clear whether genetic characteristics of the bacteria contribute to disease pathogenesis in MRSA infection. We hypothesized that whole genome analysis strains could reveal key gene loci and/or mutations affect clinical manifestations infection.Whole sequences (WGS) 154 were analyzed with respect data. Further, we evaluated association between infection genomic information.WGS...
ABSTRACT Aim High glucose (HG) induces endothelial injury in vasculature, leading to tissue diabetic condition. Therefore, diabetes is one of the major cause end‐stage kidney disease as well cardiovascular diseases. Chronic inflammation involved progression HG‐induced cell injury. Recently, it has been reported that erythropoietin (EPO) protects tissues from some kind injury, such hypoxia and mechanical stress. However, contribution EPO remains be explored. we hypothesized cells via...
Abstract Carnitine/organic cation transporter 1 (OCTN1) is the only known uptake for ergothioneine which a food-derived strong antioxidant amino acid that absorbed by OCTN1. We previously reported roles of OCTN1/ergothioneine in progression kidney fibrosis ischemic disease. In this study, we evaluated OCTN1 diabetic A disease model was induced octn1 knockout and wild-type mice streptozotocin (STZ). Oxidative stress, represented urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), were higher mice....
Kidney complications associated with anticancer drug therapy have greatly increased recently. We aimed to investigate the real-world clinical outcomes of therapy-associated renal in Japan using national kidney biopsy database, Renal Biopsy Registry (J-RBR).
Abstract Mortality from infections has been reported to be higher in hemodialysis (HD) patients. Although dysfunction of neutrophils against bacterial infection was HD patients, the precise mechanism remains clarified. We therefore examined impacts neutrophil inflammatory signaling on bactericidal activity Comprehensive analyses intracellular signalings were performed whole blood patients and control using a microarray system. To confirm contribution neutrophils, we phosphorylation, killing...