A5066471308- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Amino Acid Enzymes and Metabolism
- Acute Kidney Injury Research
- Epigenetics and DNA Methylation
- Renal and related cancers
- Renal cell carcinoma treatment
- Erythropoietin and Anemia Treatment
- Renal Diseases and Glomerulopathies
- Mycobacterium research and diagnosis
- Nutritional Studies and Diet
- Bacterial biofilms and quorum sensing
- Blood Pressure and Hypertension Studies
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Lung Cancer Treatments and Mutations
- Physical Activity and Health
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Vasculitis and related conditions
- Autophagy in Disease and Therapy
- Sodium Intake and Health
Kanazawa University
2020-2024
Hyogo Prefectural Cancer Center
2020-2023
Public Central Hospital of Matto Ishikawa
2020
Kanazawa University Hospital
2019-2020
Pediatric Nephrology of Alabama
2018
Gut microbiota-derived metabolites play important roles in health and disease. D-amino acids their L-forms are of gut microbiota with distinct functions. In this study, we show the pathophysiologic role association humans mice acute kidney injury (AKI). a mouse ischemia/reperfusion model, protected against tubular injury. AKI-induced dysbiosis contributed to altered metabolism acids. Among acids, only D-serine was detectable kidney. injured kidneys, activity acid oxidase decreased....
Significance Statement Intestinal barrier dysfunction—a “leaky gut”—reportedly contributes to pathological processes in some diseases. In a mouse model, the authors induced diabetic kidney disease, leading impaired intestinal integrity and inflammation, with IL-17 upregulation. This allowed intestine-derived Klebsiella oxytoca elevated translocate circulation kidneys, then accelerate injury, especially knockout mice lacking mitochondrial antiviral signaling protein (MAVS). Stimulation of...
Recent studies have revealed the connection between amino acid chirality and diseases. We previously reported that gut microbiota produces various d-amino acids in a murine acute kidney injury (AKI) model. Here, we further explored pathophysiological role of d-alanine (d-Ala) AKI. Levels d-Ala were evaluated AKI analyzed transcripts N-methyl-d-aspartate (NMDA) receptor, receptor for d-Ala, tubular epithelial cells (TECs). The therapeutic effect was then assessed vivo vitro. Finally, plasma...
Prognosticating disease progression in patients with diabetic kidney (DKD) is challenging, especially the early stages of disease. Anemia can occur diabetes. We therefore postulated that serum hemoglobin (Hb) concentration, as a reflection incipient renal tubulointerstitial impairment, be used marker to predict DKD progression.Drawing on nationally representative data biopsy-proven DKD, 246 who had an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 at biopsy were identified:...
Abstract Fibroblast accumulation and extracellular matrix (ECM) deposition are common critical steps for the progression of organ fibrosis, but precise molecular mechanisms remain to be fully investigated. We have previously demonstrated that lysophosphatidic acid contributes fibrosis through production connective tissue growth factor (CTGF) via actin cytoskeleton‐dependent signaling, myocardin‐related transcription family (MRTF) consisting MRTF‐A MRTF‐B‐serum response (SRF) pathway. In this...
The revision of International Society Nephrology/Renal Pathology (ISN/RPS) classification guidelines for lupus nephritis (LN) was suggested by a working group, who recommended modified National Institute Health (NIH) activity and chronicity scoring system to evaluate active chronic LN lesions. However, whether this approach useful estimating long-term prognosis patients is unclear.We conducted retrospective cohort study in Japanese subjects with biopsy-proven LN, between 1977 2018....
ABSTRACT The full-length receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor. High-mobility group box 1 (HMGB1) RAGE ligand of damage-associated molecular patterns that elicits inflammatory reactions. shedded isoform and endogenous secretory (esRAGE), splice variant, are soluble isoforms (sRAGE) act as organ-protective decoys. However, the pathophysiologic roles RAGE/sRAGE in acute kidney injury (AKI) remain unclear. We found AKI was more severe,...
Abstract PAX2 is a transcription factor essential for kidney development and the main causative gene renal coloboma syndrome (RCS). The mechanisms of action during have been evaluated in mice but not humans. This critical gap knowledge since important differences reported two species. In present study, we hypothesized that key human PAX2-dependent genes are differentially expressed nephron progenitor cells from induced pluripotent stem (iPSCs) patients with RCS relative to healthy...
Abstract Background Recent studies revealed that lysophospholipids (LPLs) and related molecules, such as autotaxin (ATX) phosphatidylserine‐specific phospholipase A 1 (PS‐PLA ), are candidates for novel biomarkers in melanoma, glaucoma diabetic nephropathy. However, it is not clear whether serum levels of ATX/ PS‐PLA would be associated with pathological clinical findings lupus nephritis (LN). Methods In this retrospective cohort study, samples were collected from 39 patients LN 37 other...
Abstract Despite treatment advances, acute kidney injury (AKI)–related mortality rates are still high in hospitalized adults, often due to sepsis. Sepsis and AKI could synergistically worsen the outcomes of critically ill patients. TLR4 signaling mitochondrial antiviral protein (MAVS) innate immune responses essential diseases, but their involvement sepsis-associated (SA-AKI) remains unclear. We studied role MAVS related pathway using a murine LPS-induced model wild-type MAVS-knockout mice....
Abstract The relationship between D-AA metabolic enzymes and cancer development remains unclear. We aimed to investigate this using mice deficient in D-AA-related enzymes. examined lacking these for approximately 900 days the effects of altered metabolism on based lifespan, pathological findings, gene expression. lifespan female DASPO -knockout ( −/− ) was shorter than that other group mice; furthermore, showed tumor-like masses liver, spleen, small intestine. A diagnosis diffuse large...
Abstract Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed new biological function trehalose as an autophagy inducer. Thus far, reports regarding the therapeutic effects on fibrotic diseases. Therefore, we examined whether has anti-fibrotic PF. PF was induced by intraperitoneal injection chlorhexidine gluconate (CG). CG challenges increase thickness, ColIα 1 mRNA expression and hydroxyproline...
The relationship between dietary habits and development of chronic kidney disease (CKD) is unclear. This retrospective cohort study was conducted to examine the association unhealthy proteinuria onset, a key prognostic factor CKD, among Japanese general population aged ≥40 years. risks onset were estimated based on status baseline (quick eating, late dinner, evening snack, skipping breakfast) compared with without these habits. A total 26,764 subjects included, mean follow-up period 3.4 most...
Progression of renal anemia has been shown to be associated with advanced tubulointerstitial lesions. This retrospective study investigated the impact lower hemoglobin (Hb) levels and interstitial fibrosis tubular atrophy (IFTA) on long-term outcomes in type 2 diabetes biopsy-proven diabetic nephropathy.A total 233 patients were enrolled. The severity IFTA was scored according classification by Renal Pathology Society. Patients stratified baseline Hb tertiles status. first occurrence events...
Abstract Background The prognosis of focal segmental glomerulosclerosis patients with nephrotic syndrome is estimated to be 10%–20% in 5 years and 30%–50% 10 years, leading end‐stage kidney disease. response rate steroid therapy 40%–60%. Therapeutic low‐density lipoprotein‐apheresis (LDL‐A) may effective resistance. Information regarding the long‐term receiving this scarce. Methods We investigated effectiveness treatment 50 primary diagnosed between 1961 2017 at Kanazawa University Hospital...
Objectives Recurrent acute kidney injury (AKI) is a recognised risk factor for mortality. However, it unclear whether the period until AKI recurrence may have major on patient outcome or not. To explore this issue, we (1) framed hypothesis that early increases of mortality and (2) evaluated prognosis recurrent cases by setting 21 days as cut-off period. Methods All studied were admitted followed up at Kanazawa University Hospital (Kanazawa, Japan) between 1 November 2006 31 October 2007. In...
Abstract We present the case of a 67-year-old man in good health with perirenal hematoma due to ruptured arterial aneurysm kidney. The patient developed weight loss, muscle weakness, multiple mononeuropathy, hypertension, anemia, renal insufficiency, and lacuna infarctions about month ago. He was admitted hospital worsening his symptom. After admission, severe right-flank pain suddenly occurred; he then transferred our hospital. Renal angiography revealed bilateral microaneurysms, diagnosed...
Abstract Carnitine/organic cation transporter 1 (OCTN1) is the only known uptake for ergothioneine which a food-derived strong antioxidant amino acid that absorbed by OCTN1. We previously reported roles of OCTN1/ergothioneine in progression kidney fibrosis ischemic disease. In this study, we evaluated OCTN1 diabetic A disease model was induced octn1 knockout and wild-type mice streptozotocin (STZ). Oxidative stress, represented urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), were higher mice....
Introduction Data on the association between longitudinal trajectory patterns of albuminuria and subsequent end-stage kidney disease (ESKD) all-cause mortality in diabetic (DKD) are sparse. Research design methods Drawing nationally representative data 329 patients with biopsy-proven DKD an estimated glomerular filtration rate above 30 mL/min/1.73 m 2 at time biopsy, we used joint latent class mixed models to identify different 2-year urine albumin creatinine ratio (UACR) assessed rates...
The number of patients with chronic kidney disease (CKD) is increasing worldwide. Cognitive impairment one the comorbidities CKD. With increased aged population, novel biomarkers impaired cognitive function are required. Intra-body profile amino acid (AA) reportedly altered in Although some AAs act as neurotransmitters brain, it not clear whether AA associated Therefore, intra-brain and plasma levels evaluated respect to CKD.Plasma were compared between 14 CKD, including 8 diabetic disease,...
Abstract Kinesin family member 26b ( Kif26b ) is essential for kidney development, and its deletion in mice leads to agenesis. However, the roles of this gene adult settings remain elusive. Thus, study aims investigate role progression renal fibrosis. A fibrosis model with adenine administration using heterozygous wild‐type was established. Renal underlying mechanism were investigated. The pathways functions evaluated an vitro primary fibroblasts. protected from administration. expressions...