A5011516349- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- Neuropeptides and Animal Physiology
- Coronary Interventions and Diagnostics
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Helicobacter pylori-related gastroenterology studies
- Immunotoxicology and immune responses
- Bone Metabolism and Diseases
- Plant Pathogenic Bacteria Studies
- Platelet Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Connective tissue disorders research
- Gastrointestinal motility and disorders
- Cerebrovascular and Carotid Artery Diseases
- Fibroblast Growth Factor Research
- Plant Virus Research Studies
- Gastroesophageal reflux and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Bone health and treatments
- Blood properties and coagulation
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
Kanazawa University
2022
Shizuoka University
2017-2020
Agricultural Research Center
2020
Terumo (Japan)
1993-2018
Takeda (Japan)
1996-2017
Nagashima Hospital
2007-2017
Catharina Ziekenhuis
2009
Radboud University Nijmegen
2009
Institut Cardiovasculaire Paris Sud
2009
Nagoya University
1993-1998
Intravenous administration of human basic fibroblast growth factor (bFGF) for 2 weeks stimulated osteoblast proliferation and new bone formation in various skeletal bones young aged rats at dosage levels 0.1 mg/kg/day greater. Morphometry the soft X-ray radiograms cross sections tibia indicated about a 20% increase calcified area diaphysis mg/kg/day. The Ca hydroxyproline contents showed statistically significant increases this dosage. was found only on endosteal side, no periosteal found....
Background— The newly developed Nobori coronary stent coated with a bioresorbable polymer, polylactic acid, and the antiproliferative agent Biolimus A9 has potential to reduce restenosis by suppressing neointima formation. Methods Results— We conducted randomized (2:1), controlled trial comparing A9-eluting paclitaxel-eluting Taxus Liberté, in 243 patients (153 90 Taxus) at 29 centers Europe, Asia, Australia. Patients previously untreated lesions up 2 native arteries were considered for...
The identification of adverse health effects has a central role in the development and risk/safety assessment chemical entities pharmaceuticals. There is currently need for better alignment regarding how nonclinical adversity determined characterized. European Society Toxicologic Pathology (ESTP) therefore coordinated workshop to review available definitions adversity, weigh determining qualifying factors based on case examples, recommend practical approach define characterize toxicology...
We studied a 66-year-old man with myeloproliferative disorder who presented prolonged bleeding time and marked thrombocytosis (platelet count, 3,890 x 10(9)/l). There was no past history of disorder. The patient had normal coagulation data. His platelets completely lacked collagen-induced platelet aggregation adhesion, but showed responses to other agonists. All family members tested collagen. Analysis 125I surface-labeled by two-dimensional SDS gel electrophoresis disclosed absence the spot...
To predict drug-induced serious adverse events (SAE) in clinical trials, a model using panel of cells derived from human induced pluripotent stem (hiPSCs) individuals with different susceptibilities could facilitate major advancements translational research terms safety and pharmaco-economics. However, it is unclear whether hiPSC-derived can recapitulate interindividual differences SAE susceptibility populations not having genetic disorders such as healthy subjects. Here, we evaluated...
This study reports the development of a loop-mediated isothermal amplification (LAMP) reaction for detection Pythium myriotylum. The primer set targeting ITS sequence P. myriotylum worked most efficiently at 60°C and allowed DNA within 30 min by fluorescence monitoring using real-time PCR instrument. peak denaturing temperature amplified was about 87·0°C. In specificity tests eight strains, 59 strains from 39 species Pythium, 11 Phytophthora other soil-borne pathogens, LAMP gave no...
Root rot of poinsettia, caused by Pythium helicoides at high temperatures in hydroponic cultures, has become a serious problem many parts the world. We have developed species-specific, loop-mediated isothermal amplification (LAMP) assay for rapid diagnosis this pathogen. The primers were designed using ribosomal DNA internal transcribed spacer sequence. Primer specificity was established 40 species including P. helicoides, 11 Phytophthora species, and eight other soil-borne pathogens. A...
Drug-eluting stents (DES) were introduced into clinical practice in 2002 order to reduce restenosis that occurred 15–25% of patients receiving bare-metal (BMS).1–3 Subsequent trials with different types DES confirmed their efficacy this regard.4 However, late stent thrombosis was reported as early 2004, typically discontinuing dual anti-platelet therapy.5 At the European and World Congress Cardiology Barcelona 2006, alarming data presented on a worse long-term prognosis following...
The purpose of this report is to describe the morphological and clinical features two patients with focal choroidal excavation in an attempt understand more about rare condition.Spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography, indocyanine green angiography were used assess characteristics patients' excavations. Both showed following on SD-OCT: (1) retinal pigment epithelium band inner/outer segment junction followed contour excavation, which involved outer...
TAK-778 [(2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4, 5-tetrahydro-4-methyl-7, 8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide; mw 505.53], a novel osteoblast differentiation promoting compound, was characterized in vitro and vivo models. at doses of 10(-6) M higher promoted potently bone-like nodule formation the presence dexamethasone rat bone marrow stromal cell culture. This accompanied by increases cellular alkaline phosphatase activity, soluble collagen release,...
Adrenomedullin (AM), belongs to the calcitonin gene-related peptide (CGRP) family and interacts with AM CGRP1 receptors. Specific receptors immunoreactivity are present in rat brain. The effect of intracisternal injection on ethanol-induced gastric lesions was studied conscious Wistar rats. injected intracisternally or intravenously under short anesthesia 20 min before intragastric 70% ethanol. Corpus were determined 1 h after Intracisternal (75, 150, 300 pmol) dose-dependently inhibited by...
Suitable evaluation systems are critical for ranking various biomaterials in order to develop a method design and synthesize nonthrombogenic biomaterials. We have recently developed an vitro test system evaluate platelet/biomaterial interactions whole blood. The consists of parallel plate flow cell epifluorescent video microscopy (EVM). A glass coverslip coated with polymer was incorporated into the cell, blood perfused using syringe pump via polymer-coated PVC tubing connected cell. Whole...