A5019687935- Sarcoma Diagnosis and Treatment
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Corneal surgery and disorders
- Adenosine and Purinergic Signaling
- Glaucoma and retinal disorders
- Radiopharmaceutical Chemistry and Applications
- Musculoskeletal synovial abnormalities and treatments
- Genomics, phytochemicals, and oxidative stress
- Diabetes and associated disorders
- Bone Tumor Diagnosis and Treatments
- Sports Analytics and Performance
- Peroxisome Proliferator-Activated Receptors
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Urinary and Genital Oncology Studies
- Sports Performance and Training
- Philosophy, Science, and History
- Philosophy and History of Science
- COVID-19 Clinical Research Studies
- Gastrointestinal disorders and treatments
- Corneal Surgery and Treatments
- Genital Health and Disease
- Gastrointestinal Tumor Research and Treatment
- Amino Acid Enzymes and Metabolism
Kyoto Prefectural University of Medicine
2006-2024
University of Tsukuba
2024
The University of Tokyo
2000-2020
Tanta University
2010
Tochigi Cancer Center
2008
Salk Institute for Biological Studies
2005
Jikei University School of Medicine
1989-1999
National Center of Neurology and Psychiatry
1995
Meijo Hospital
1981
The growth type of early colorectal carcinoma was classified into two types. first is intramucosal polypoid (PG-Ca) and the second nonpolypoid (NPG-Ca) which shows mainly massive infiltration tumor cells below submucosal layer. incidence adenoma-carcinoma sequence 72 75 lesions (96.0%) in pedunculated carcinoma, 61 71 (85.9%) sessile broad-based carcinomas. Their average sizes were 15.0 18.7 mm, respectively. Submucosal invasive (SM-Ca) showed a low incidence. They detected as microscopical...
Abstract: We compared the activity of free d ‐Ser on potentiation cloned NMDA receptors with that Gly by using a Xenopus oocyte expression system. The extracellular concentration and was further studied means microdialysis. ED 50 values were three to four times lower than those in any combination ε1, ε2, ε3, or ε4 ζ1. Site‐directed mutagenesis ζ1 subunits revealed some aromatic residues necessary for action affected value ‐Ser. This result showed play crucial roles In vivo microdialysis...
As the expression of cyclin D1 is induced during liver regeneration and also in hepatic tumor cells, likely to play an important role proliferation transformation hepatocytes. However, development remains unknown. Here we show that D-type cyclins including D1, D2, D3 down-regulated along with development. In addition, oncostatin M (OSM), interleukin-6 family cytokine, D2 a primary culture fetal hepatocytes which OSM induces differentiation. Ectopic receptor mutants defective activation...
Sulforaphane (SFN), a naturally occurring isothiocyanate, is an attractive agent because of its potent anticancer effects. SFN suppresses the proliferation various cancer cells in vitro and vivo. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) also one most promising candidates for therapeutics owing to ability selectively induce apoptosis tumor cells. In this study, we report that enhances TRAIL-induced human osteosarcoma cells, Saos2 MG63. The induced by co-treatment with...
Bisphosphonates (BPs) are widely used to treat bone diseases and also appear possess direct antitumour activity. We have previously reported that third-generation BPs such as zoledronic acid (ZOL) minodronic (YM529) synergistically augment the effects of anticancer agents in various cancer cells. Recently, we YM529 on murine osteosarcoma As has not been clinically available, herein focused anti-osteosarcoma ZOL which is available. In addition alone, evaluated concurrent or sequential...
Abstract Context Branched-chain amino acids (BCAA) are substrates for protein synthesis. Although their intake may contribute to an increase in skeletal muscle mass, elevated serum BCAA levels have been reported be associated with insulin resistance, potentially resulting decreased mass. Objective This study aimed explore the association between and longitudinal loss. Design Setting A cohort analysis was conducted, which were analyzed healthy individuals who underwent a medical health...
We previously established a bioassay method to screen for compounds that activate the promoter activity of p21WAF1/CIP1, potent inhibitor cyclin-dependent kinases, in p53-independent manner. As an activator p21WAF1/CIP1 activity, we isolated cryptolepine (CLP: 5-methyl indolo (2,3b)-quiniine), indoloquinoline alkaloid, from traditional Ayurvedic medicinal plant Sida cordifolia. show here CLP induces expression with growth arrest p53-mutated human osteosarcoma MG63 cells. Four micromolar...
The purpose of this report is to describe the morphological and clinical features two patients with focal choroidal excavation in an attempt understand more about rare condition.Spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography, indocyanine green angiography were used assess characteristics patients' excavations. Both showed following on SD-OCT: (1) retinal pigment epithelium band inner/outer segment junction followed contour excavation, which involved outer...
We recently demonstrated that oncostatin M (OSM) in the presence of glucocorticoid promotes development fetal hepatic cells a primary culture system. Our results also suggested OSM transduces differentiation signals through gp130, common subunit interleukin (IL)-6 family cytokine receptors. However, an essential downstream pathway required for remains unknown. To address this issue, we expressed signal molecules by retroviral expression vector and investigated signaling OSM-mediated...
The clinically relevant histone deacetylase inhibitors (HDI) valproic acid (VPA) and suberoylanilide hydroxamic exert variable antitumor activities but increase therapeutic efficacy when combined with other agents. natural endogenous ligand of peroxisome proliferator-activated receptor gamma 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a potent antineoplastic agent. Therefore, we investigated whether these HDIs in combination 15d-PGJ(2) could show synergistic activity colon...
To provide insight into the mechanism underlying corneal deformation in keratoconus, we examined relations among curvature, thickness, and volume as well association of scar formation with these parameters.A total 288 corneas 174 keratoconus patients 114 57 control subjects were by anterior segment-optical coherence tomography (AS-OCT). Anterior posterior refractive values, thickness (CT), (CV) determined AS-OCT for both keratoconic eyes. The pattern stromal scarring was also from images.The...
Diabetes is a common comorbidity in patients with coronavirus disease (COVID-19) and contributes significantly to COVID-19 severity. We aimed investigate the association between diabetic status severe COVID-19. This prospective study included all admitted our hospital, who were divided into four groups according their status: no diabetes, treated untreated COVID-19-related diabetes. Severe was defined as condition that required use of ventilator. Of 114 this study, 26 had The adjusted odds...
This study aimed to investigate the association between change in body weight (BW) and type 2 diabetes remission Japanese men with new-onset diabetes.This enrolled 1,903 patients 2008 2013 from a medical health checkup program conducted by Panasonic Corporation, Osaka, Japan. The baseline was defined as year of diabetes. We assessed five years after BW using logistic regression analyses. To evaluate predictive performance BW, we employed receiver operating characteristic curves area under...
Detection of refractive error in children is crucial to avoid amblyopia and its impact on quality life. We here performed a retrospective study order develop prediction models for spherical cylinder refraction children. The enrolled 1221 eyes 617 were divided into three groups: the development group (710 359 children), validation (385 194 comparison (126 64 children). determined noncycloplegic cycloplegic values by autorefractometry. In addition, several parameters assessed with use ocular...
Zoledronic acid (ZOL), a third-generation bisphosphonate, inhibits bone resorption, as well exhibiting direct antitumor activity. To date, however, the combined effects of ZOL and ionizing radiation (IR) have not been assessed in patients with soft tissue sarcoma. We have, therefore, IR fibrosarcoma cells. HT1080 cells were treated and/or IR, together or sequentially assessed. found that significantly enhanced IR-induced apoptosis, especially when followed by IR. We, detailed mechanism...