A5075604884- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Renal and Vascular Pathologies
- Genetic Syndromes and Imprinting
- Platelet Disorders and Treatments
- Muscle and Compartmental Disorders
- Erythropoietin and Anemia Treatment
- Systemic Sclerosis and Related Diseases
- Heart Failure Treatment and Management
- Liver Disease and Transplantation
- Renal function and acid-base balance
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and healthcare impacts
- Gout, Hyperuricemia, Uric Acid
- Sarcoidosis and Beryllium Toxicity Research
- Electrolyte and hormonal disorders
- Iron Metabolism and Disorders
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Renal and related cancers
Nippon Medical School
2011-2025
Nippon Medical School Musashi Kosugi Hospital
2024
Japanese Society for Dialysis Therapy
2021
Nippon Medical School Hospital
2021
Chiba Hokusou Hospital
2018
Abstract The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4458 dialysis facilities at end 2018; among these facilities, 4402 (98.7%) responded facility questionnaire, and 4222 (94.7%) patient questionnaire. number chronic patients in Japan continues increase every year; as 2018, it had reached 339,841 patients, representing 2688 per million population. Among prevalent mean age 68.75 years, diabetic nephropathy most common primary disease...
Abstract Background The 2020 Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) annual survey was sent to 4493 dialysis facilities in Japan. Methods Questionnaires were all that provide patients with therapy collected and compiled form cross-sectional results of renal replacement from various aspects. Results In total, 4437 (98.8%) responded the facility questionnaire 4271 (95.1%) patient questionnaire. number chronic Japan continues increase every year, reaching 347,671 at end...
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many cancers, including cancers head and neck. Despite promising therapeutic efficacy ICIs, immune-related adverse events (irAEs) are a major concern. Acute tubular injury interstitial nephritis most common irAEs involving kidneys. The present patient was diagnosed as having advanced papillary squamous cell carcinoma After failure initial treatments, chemotherapy, nivolumab (programmed death-1 inhibitor) introduced....
Hemodialysis is a treatment in which uremic toxins and excess water content are removed from the blood with dialyzer dialysis fluid. The efficiency of hemodialysis strongly influenced by following 3 parameters: flow rate (QB), fluid (QD), overall mass transfer area coefficient (K0A), an index dialyzer's performance. ratio (QB : QD) to obtain well-balanced generally said be 1 2. In Japan, QB controlled independently (from 200 250 mL/min) depending on individual conditions. However, QD usually...
<i>Background/Aims:</i> The diagnostic value of N-terminal pro-brain natriuretic peptide (NT-pro BNP) for heart failure with preserved ejection fraction (EF; HF-PEF) was evaluated in hemodialysis (HD) patients. <i>Method:</i> In total, 83 patients were analyzed. Left-ventricular (LV) function assessed using trans-thoracic Doppler echocardiography, and indices hydration status bioelectrical impedance analysis. Plasma NT-pro BNP levels measured simultaneously....
Abstract Introduction There is little evidence for ivabradine hydrochloride in patients undergoing hemodialysis. Methods In this open‐label prospective interventional trial of hemodialysis with chronic heart failure, during 12 weeks treatment, changes Heart rate (HR), frequency dialysis‐related hypotension were examined, and we investigated health‐related quality life (HR‐QOL) adverse effects. Results 18 from 6 facilities enrolled the study. HR significantly decreased over time, 87 ±...
Febuxostat is recommended for treatment of severe hyperuricemia in chronic kidney disease (CKD). We previously reported a significant positive correlation between fractional excretion uric acid (FEUA) and estimated (eEUA) patients receiving febuxostat proposed that the addition uricosuric agents could further decrease serum (sUA) levels by enhancing FEUA eEUA treated with febuxostat.
Abstract Endocapillary proliferation occurs in various types of glomerulonephritis (GN), with varying prognoses. We examined 42 renal biopsy samples representing endocapillary proliferative lesions from post-streptococcal acute GN (PSAGN), Henoch–Schönlein purpura nephritis (HSPN), and lupus (LN). In PSAGN, the glomerular capillary network was maintained, although severe displayed dots or short, curved lines, indicating CD34-positive capillaries suggesting obstruction. Conversely, patients...
Background: Hemodialysis is a method for removing uremic toxins and water directly from the blood into dialysis fluid through an artificial semipermeable membrane called dialyzer. The ability of dialyzer to remove has steadily improved, but likelihood also increased that bioactive substances, such as bacterial endotoxin (ET) fragments, can be transferred patient's phenomena back-diffusion back-filtration in Therefore, further efforts improve quality are required. In 2008, Committee...
A 34-year-old female patient presented to our hospital with lower extremity edema and proteinuria during pregnancy. Renal biopsy was performed the diagnosed nephrotic syndrome due lupus-like membranous nephropathy. This diagnosis reached upon as laboratory findings admission, wherein both anti-nuclear anti-double-stranded DNA antibodies revealed negative, did not fulfill criteria for systemic lupus erythematosus (SLE) proposed by American College of Rheumatology (ACR) reveal any typical...
AN69 dialyzer, a plate type dialyzer with polyacrylonitrile membrane (PAN membrane) is reported to reduce symptoms in hemodialysis (HD) patients complications such as poor nutritional status and peripheral arterial disease (PAD). Yet very few studies have investigated the long-term use of PAN or compared solute-removal properties those Type IV polysulfone (PS membrane), dialysis most widely used. In present study we contaminant-removal PS clinical effects former for elderly mild...
We report a case of necrotic crescentic glomerulonephritis (GN) and tubular interstitial nephritis (TIN) with antiglomerular basement membrane (GBM) antibodies following immune checkpoint inhibitor, nivolumab, administration. A 74-year-old man was diagnosed stage IB nonsmall cell lung cancer underwent surgery 4 years prior to admission, followed by recurrence after 3 years. Nivolumab (3.75 mg/kg) administrated for total 6 cycles over months. The patient presented general fatigue, fever,...
Abstract: Although parathyroidectomy (PTX) is the ultimate treatment for secondary hyperparathyroidism (SHPT) that resistant to medical treatment, recent advances in ultrasonographic techniques have increased options Japan. Percutaneous ethanol injection therapy (PEIT) of parathyroid was approved under national health insurance system 2004, and there been trials direct vitamin D (VD) preparations. We followed 30 patients at least 1 year who had undergone PEIT same institution. The overall...
Abstract According to the annual survey of Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) conducted at end 2018, there were a total 339,841 patients receiving dialysis (hereinafter, patients) in Japan. The included questions regarding presence/absence dementia, performance status (PS), and exercise habits individual patients. revealed that 10.8% all had dementia (1.8% age group less than 65 years, 6.8% 65–74 22.7% 75 years or older). These prevalences approximately equal...
Focal segmental glomerular sclerosis (FSGS) is caused by podocyte injury. It characterized obliteration of capillary tufts with increased extracellular matrix (ECM). Altered communication between podocytes and endothelial cells (ECs) contributes to progression. We focused on EC injury in the FSGS.A total 29 FSGS 18 control biopsy specimens were assessed for clinicopathologic characteristics. CD34 (a marker EC)-positive capillaries ECM accumulation evaluated quantitatively each variant using...
Background: The COVID-19 pandemic has had an enormous impact on hemodialysis patients. This study investigated changes in treatment at our hospital after the start of pandemic.
The increasing prevalence of chronic kidney disease (CKD) requires effective preventive measures, particularly due to an aging population. This study aimed assess the effectiveness home visit rehabilitation in preventing renal function decline among patients with CKD.
Maintenance hemodialysis patients are immunosuppressed, which increases their mortality risk if they contract coronavirus disease 2019 (COVID-19).
Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT), secondary to cardiovascular disease and sepsis, is associated with high in-hospital mortality. Although studies have examined sepsis in AKI, the association between AKI hepatic functional impairment remains unclear. We hypothesized that function markers would predict mortality patients undergoing CRRT. included 1,899 CRRT from a multi-centre database. In Phase 1, participants were classified according total...
Background: Vascular access intervention therapy (VAIVT) is widely used as a treatment for arteriovenous fistula (AVF) failure. However, recurrent AVF failure major concern dialysis patients. By prospectively observing patients after an initial VAIVT, we attempted to identify risk factors developing restenosis of AVF. Methods: This single-center prospective study evaluated 57 who underwent their first VAIVT procedure at our hospital from April 2022 through March 2023. We performed blood and...
ABSTRACT Background and Aims Hypertensive emergencies, characterized by elevated blood pressure (BP) multiple organ damage, have poor prognosis. Patients occasionally show gradual improvement in renal function with appropriate antihypertensive treatment despite impairment. However, reports analyzing factors predicting prognosis patients hypertensive emergencies severe impairment are limited. This retrospective study aimed to investigate clinical features predictors of outcomes such patients....
Abstract The annual survey of the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry (JRDR) at end 2021 was conducted 4508 facilities, which 4454 facilities (98.8%) returned facility questionnaire and 4251 (94.3%) patient questionnaire, giving response rates as high those in previous years. number dialysis patients Japan has been increasing year by year, reaching 349,700 or 2786 per million population according to results survey. mean age based on 69.67 years, with most common...