Acquired coagulopathy is uncommon. Cases of hemophilia A, which characterized by reduced coagulation factor Ⅷ, have been reported but cases involving diminished factors VII, Ⅺ, or XII not reported. We report the case a patient who presented with chronic subdural hematoma (CSDH), was challenging to treat due underlying acquired abnormalities. Middle meningeal artery (MMA) embolization promising approach for managing refractory CSDH and has proved effective in this case. An 82-year-old man no...

Object. Hemoglobin causes contraction of cerebral arteries and is also believed to cause vasospasm after subarachnoid hemorrhage (SAH). The goal in this study was determine if overexpression heme oxygenase-1 (HO-1), the principal enzyme involved metabolism hemoglobin, would reduce contractions brought on by hemoglobin decrease experimental SAH. Methods. Injection adenovirus expressing HO-1 (Ad5HO-1) into cisterna magna rats produced a significant increase expression messenger RNA, protein...

In single vascular smooth muscle cells (VSMCs) isolated from the aortae of male Wistar rats, we examined effects nitric oxide (NO) donors such as sodium nitroprusside (SNP) and S‐nitroso‐N‐acetyl‐ dl ‐penicillamine (SNAP), 8‐bromo‐guanosine‐3′:5′‐cyclic monophosphate (8‐bromo‐cyclic GMP) on endothelin‐1 (ET‐1)‐activated Ca 2+ ‐permeable nonselective cation channel by use whole‐cell recordings patch‐clamp technique monitoring intracellular free concentration ([Ca ] i ) with fura‐2 real‐time...

We have recently shown that endothelin‐1 (ET‐1) activates two types of Ca 2+ ‐permeable nonselective cation channels (designated NSCC‐1 and NSCC‐2) store‐operated channel (SOCC). These can be pharmacologically discriminated using blockers such as SK&F 96365 LOE 908. Here we characterized entry involved in ET‐1‐induced contractions rat thoracic aortic rings increases the intracellular free concentration ([Ca ] i ) single smooth muscle cells these blockers. 908 or a blocker...

Recombinant human ET A receptors were expressed in a mouse fibroblast cell line ( Ltk − cell) and functional coupling of the with Ca 2+ permeable channels at low concentrations endothelin‐l (ET‐1) was investigated using whole‐cell recordings monitoring changes intracellular free ([Ca ] i ) indicator, fluo‐3. similar type freshly dispersed vascular smooth muscle cells (VSMCs) rabbit thoracic aorta by use recordings. In L tk expressing recombinant receptors, ET‐1 (10 −8 M , 10 −9 evoked an...

Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, underlying pathophysiology relation to aging process remains unclear. To investigate effect of removal cerebrospinal fluid by lumbar "tap test" on cerebral circulation iNPH patients, 14 "probable" patients were studied using novel blood tracking technique based oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By propagation low-frequency component BOLD...

Background and Purpose — We studied in monkeys why vasospasm resolves after subarachnoid hemorrhage (SAH). Methods Monkeys underwent angiography right (n=17) or bilateral (n=8) SAH. Animals with SAH 1, 3, 5, 7 days later. The clot was then not removed (n=5), replaced fresh (n=7), (n=5). At the same time on day 7, (n=12) (n=5) placed left side. Angiography repeated every 2 until 14. Results caused significant that resolved by Removal of resulted more rapid resolution vasospasm. Placement onto...

We previously showed a role for nonselective cation channel (NSCC) in the ETA-dependent action of endothelin-1 mouse fibroblast and rabbit aortic smooth-muscle cell. To clarify physiological significance NSCCs (ET-1)-induced vasocontraction, we examined effects NSCC blockers such as mefenamic acid SK&F 96365 on contractions deendothelialized rings induced by low (10−10M) or high (10−8M) concentration ET-1. Mefenamic (≤10−3M) had little effect contraction 45 × 10−3M K+ 1 10−6M Bay K-8644...

Carbon monoxide (CO) is known to increase cerebral blood flow, but the effect of CO on vascular tone large arteries uncertain. We tested whether affects artery by measuring tension generated ex vivo segments dog basilar upon exposure CO. In contracted with either KCl or prostaglandin F(2alpha), caused a concentration-related relaxation beginning concentration 57 microM. Relaxation did not occur if was administered in presence bubbling carboxygen (95% O(2):5% CO(2)), which reduces greater...

Walking ability is important in stroke patients to maintain daily life. Nevertheless, its improvement limited with conventional physical therapy chronic stage. We report the case of a patient showing remarkable gait function after new neurorehabilitation protocol using transcranial direct current stimulation (tDCS) and neuromuscular electrical (NMES).A 62-year-old male left putaminal hemorrhage suffered from severe right hemiparesis. He could move by himself wheelchair 1 year ictus. Anodal...

The vasocontracting effect of a serine protease trypsin and its mechanisms were investigated by monitoring the isometric tension in endothelium‐denuded rings rabbit thoracic aortae effects on intracellular free Ca 2+ concentrations ([Ca ] i ) dispersed vascular smooth muscle cells with indicator fura‐2. actions compared those thrombin. Both thrombin reversibly contracted aortic without endothelium concentration‐dependent manner. vasocontraction induced was well correlated activity actually...

Complementary deoxyribonucleic acid array analysis was used to determine whether vasospasm after subarachnoid hemorrhage (SAH) is associated with changes in gene expression.Right SAHs were created three monkeys, and the right left middle cerebral arteries collected 3, 7, or 14 days SAH. Vasospasm assessed by angiography performed on Day 0 at tissue harvest. A complementary containing 5184 genes screen for expression comparing arteries.There significant (greater than fivefold of messenger...

<b><i>Introduction:</i></b> Astasia is a rare presenting symptom of stroke, usually known as ‘thalamic astasia', induced by lesion in the ventrolateral thalamus. We report case caudal cingulate infarction manifesting astasia. <b><i>Case Presentation:</i></b> A 58-year-old male presented with inability to sit, stand and walk (astasia). No apparent motor weakness was noticed extremities. MRI revealed cerebral gyrus, which located between vertical...

An 83-year-old man suffered from cerebral infarction of the right middle artery territory. In association with severe left hemiparesis and hemispatial neglect on side, he showed pusher phenomenon (PP), which made rehabilitation difficult. Transcranial direct current stimulation (tDCS) was applied to parietal area (2 mA × 20 min/day; anode cathode left) for 8 days, resulted in remarkable improvement PP caused prolongation static sitting time. tDCS could be a novel treatment option following stroke.

【目的】Covered stentを用いて治療した巨大頚部仮性動脈瘤の２例を報告する．【症例1】72歳男性の末期癌患者．主訴は右頚部腫脹と嗄声であった．総頚動脈の蛇行が著しいため外科的に血管を露出して直接穿刺し，covered stentとbare stentを２重に留置して動脈瘤を閉塞させた．【症例2】71歳女性の進行癌患者．主訴は右頚部腫脹，嗄声及び呼吸困難であった．大腿動脈ルートでcovered stentを留置したが滑脱したため，bare stentで滑脱を修正した後，もう１本のcovered stentを用いて３重にステントを留置して動脈瘤を閉塞させた．【結論】Covered stent留置術は巨大頚部仮性動脈瘤に対して有効な治療法と考えられる．

Endothelin-1 (ET-1) induces persistent vasoconstriction via a sustained increase in intracellular free Ca2+ concentrations ([Ca2+]i). The mechanisms of the elevation [Ca2+]i operating at physiologically low ET-1 are controversial. Here we report that both native ETA receptors vascular smooth-muscle cells and recombinant ET(A) expressed mouse fibroblasts (Ltk cells) functionally coupled with non-selective cation channel, which is permeable to blocked by mefenamic acid. channel persistently...

A 48-year-old female presented with a rare case of adult T-cell leukemia/lymphoma (ATL) occurring as only intracerebral mass lesion manifesting progressively worsening headaches, transient mild weakness the left lower extremity, bilateral papilledema, and homonymous hemianopsia. Laboratory examination showed leukocytosis (15900/μl) without febrile episode or elevation C-reactive protein. Neuroimaging revealed solitary enhanced in right occipital lobe adjacent to choroid plexus prominent...

Dialysis membranes are generally considered to be impermeable for bacterial endotoxin (lipopolysaccharide, LPS) contaminated in dialysates used hemodialysis therapy, since LPS molecular size aqueous media has been reported more than 10(6). However, there few reports concerning its dialysates. We have already presented a newly developed polyacrylamide gel electrophoresis with sodium deoxycholate (DOC-PAGE) which proves the size. Using this method, therefore, we attempted clarify of...

It is known that vasospastic arteries have reduced compliance and contractility exhibit changes in expression of various proteins [, ]. possible they may be altered a manner reduces their reactivity to blood clot thereby contributes the reversal vasospasm. These experiments determined if subarachnoid induces positive adaptive response cerebral renders them less responsive subsequent challenge with blood.

Stroke survivors who remain dependent require multiple healthcare resources, including rehabilitation and nursing care. The effect of premorbid instrumental ADL (IADL) on the discharge destination, which has not been studied previously in detail, is analyzed.Between April September 2015, 40 stroke patients admitted to hospital were enrolled prospectively present study. (Barthel index) IADL (Frenchay activities index: FAI) scores their status recorded. Baseline demographic data, severity...