A5028425029- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Estrogen and related hormone effects
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cervical Cancer and HPV Research
- Glioma Diagnosis and Treatment
- Muscle Physiology and Disorders
- Hepatitis B Virus Studies
- Prostate Cancer Treatment and Research
- Histone Deacetylase Inhibitors Research
- Leprosy Research and Treatment
- Leptospirosis research and findings
- S100 Proteins and Annexins
- Inflammatory Myopathies and Dermatomyositis
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
Sapporo Kosei General Hospital
2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2010-2023
Universidade de São Paulo
2011-2022
Universidade Brasil
2022
The University of Tokyo
2008-2009
Instituto Adolfo Lutz
1990-2008
Japan Biological Informatics Consortium
2008
Hitachi (Japan)
2008
Research Organization of Information and Systems
2008
National Institute of Advanced Industrial Science and Technology
2008
Glioblastoma ( GBM ), the most frequent and aggressive brain tumor, is characterized by marked angiogenesis directly related to invasiveness poor prognosis. Hypoxia considered be an important stimulus for inducing hypoxia‐inducible factor 1‐alpha HIF ‐1α) overexpression that activates platelet‐derived growth PDGF ) VEGF . The aim of this study analyze expression ‐ C , in endothelial tumor cells their relation ‐1α expression. Two hundred eight cases were studied tissue microarray...
Steroidogenic factor 1 (SF-1) is a key determinant of endocrine development and function adrenal cortex. SF-1 overexpression gene amplification were previously demonstrated in small group pediatric adrenocortical tumors.Our objective was to determine the frequency protein expression large cohort adult tumors.SF-1 assessed 103 tumors from 36 children 67 adults, whereas studied 38 (17 children).Tissue microarray, multiplex ligation-dependent probe amplification, quantitative real-time PCR...
Background/Aim: Several studies have reported the association between lenvatinib (LEN) treatment and nutritional indices. However, no study has used multiple indices or their changes during treatment. This aimed to clarify LEN status. Patients Methods: with hepatocellular carcinoma (n=103) treated were divided into two groups, namely normal poor using Controlling Nutritional Status (CONUT) score, Onodera-Prognostic Index (O-PNI), modified Glasgow Prognostic Score (mGPS), Geriatric Risk...
Paracoccidioidomycosis (PCM) is a severe disease caused by the dimorphic fungus Paracoccidioides brasiliensis, which characterized granulomatous pulmonary and systemic lesions, affecting mainly men between 20 60 years of age. Reports PCM in animals are rare, but has been described armadillos. On other hand, infection domestic wild detected serological or cutaneous tests absence apparent frequently reported. We present here case female adult Doberman that developed cervical lymphadenomegaly....
Abstract: Dry eye is a multifactorial disease comprising wide spectrum of ocular surface alterations and symptoms discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control prevent damage. However, in severe conditions caused by cicatricial disorders, such as Stevens–Johnson syndrome mucous membrane pemphigoid, noninvasive treatments insufficient, at risk developing complications that can lead blindness. The use salivary glands source...
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high prevalent, incurable, and routinely fatal. possess abnormal DNA methylation frequent β-catenin-activating mutations. Here, we demonstrated that maintained by balance between nuclear, β-catenin-containing complexes, the epigenome. On chromatin, β-catenin bound master adrenal transcription factor SF1 hijacked...
This study was designed to analyze the cross-sectional comparison of p16 and Ki-67 immunocytochemical expression in negative equivocal (atypical squamous cells undetermined significance (ASC-US)) liquid-based cytology (LBC) samples testing positive for high-risk human papillomavirus (HPV) types with HC2 assay or polymerase-chain reaction (PCR). A series 199 consecutive LBC specimens derived from same number women participating ongoing Latin American Screening Study at Leonor Mendes de Barros...
We previously identified dermicidin (DCD), which encodes a growth and survival factor, as gene amplified overexpressed in subset of breast tumors. Patients with DCD-positive cancer have worse prognostic features. therefore searched for specific molecular signatures carcinomas from patients representative cell lines.DCD expression was evaluated by qRT-PCR, immunohistochemical immunoblot assays normal neoplastic tissues lines. To investigate the role DCD tumorigenesis, we analyzed consequences...
LIN28 control cells reprogramming and pluripotency mainly through miRNA regulation has been overexpressed in many advanced cancers. In this study, we evaluated the prognostic role of its regulatory miRNAs a large cohort adrenocortical tumours (ACTs).LIN28 protein expression was assessed 266 adults ACTs (78 adenomas 188 carcinomas) from Brazil Germany. LIN28A LIN28B gene analysed 59 (31 28 copy number variation 39 ACTs. addition, determined let-7 family, mir-9, mir-30 mir-125...
OBJECTIVES:We investigated four components of the Wnt signaling pathway in medulloblastomas.Medulloblastoma is most common type malignant pediatric brain tumor, and has been shown to be activated this tumor.METHODS: Sixty-one medulloblastoma cases were analyzed for b-catenin gene (CTNNB1) mutations, protein expression via immunostaining pathway-related expression.All data correlated with histological subtypes patient clinical information.RESULTS: CTNNB1 sequencing analysis revealed that 11...
Medulloblastomas (MBs) and glioblastomas (GBMs) are high-incidence central nervous system tumors. Different origin sites changes in the tissue microenvironment have been associated with onset progression. Here, we describe differences between extracellular matrix (ECM) signatures of these We compared proteomic profiles MB GBM decellularized tumor samples each other their normal brain site counterparts. Our analysis revealed that 19, 28, 11 ECM proteins were differentially expressed MBs,...
Completion of human genome sequencing has greatly accelerated functional genomic research. Full-length cDNA clones are essential experimental tools for analysis genes. In one the projects New Energy and Industrial Technology Development Organization (NEDO) in Japan, full-length project (FLJ project), nucleotide sequences approximately 30 000 have been analyzed. The Gateway system is a versatile framework to construct variety expression various experiments. We constructed 33 275 entry from...
// Gabriela Resende Vieira de Sousa 1 , Tamaya C. Ribeiro Andre M. Faria Beatriz M.P. Mariani Antonio Lerario 1, 2 Maria Claudia N. Zerbini 3 Iberê Soares Alda Wakamatsu Venancio A.F. Alves 2, Berenice B. Mendonca Candida B.V. Fragoso Ana Latronico Madson Q. Almeida Unidade Suprarrenal, Endocrinologia do Desenvolvimento, Laboratório Hormônios e Genética Molecular LIM42, Divisão Metabologia, Hospital das Clínicas, Faculdade Medicina da Universidade São Paulo, SP, Brazil Instituto Câncer...
Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of gastrointestinal tract, most often stomach. Although it generally believed to represent reactive, nonneoplastic condition, its histogenesis remains controversial.To study inflammatory by immunohistochemistry an attempt further clarify their histogenesis.Nine cases were studied using panel antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56).There was strong...
Research Articles| February 23 2011 Hybrid Capture II and Polymerase Chain Reaction for Identifying HPV Infections in Samples Collected a New Collection Medium: A Comparison Topic Article Package: Cytology Subject Area: Pathology Cell Biology Suely Nonogaki; Nonogaki From the Division, Adolfo Lutz Institute Leonor Mendes de Barros Hospital, São Paulo, Brazil, Istituto Superiore di Sanità, Rome, Italy. Search other works by this author on: This Site PubMed Google Scholar Alda Wakamatsu;...
Non-alcoholic fatty liver disease (NAFLD) encompasses the whole spectrum of steatosis, non-alcoholic steatohepatitis (NASH), and NASH-related cirrhosis (NASH/Cir). Although molecular advances have been made in this field, pathogenesis NAFLD is not completely understood. The gene expression profiling associated to NASH/Cir was assessed, an attempt better characterize pathways involved its etiopathogenesis.In first step, we used cDNA microarray evaluate profiles normal (n=3) samples by...
Limb-girdle muscular dystrophy presents with heterogeneous clinical and molecular features. The primary characteristic of this disorder is proximal weakness variable age onset, speed progression, intensity symptoms. Sarcoglycanopathies, which are a subgroup the limb-girdle dystrophies, caused by mutations in sarcoglycan genes. Mutations these genes cause secondary deficiencies other proteins, due to instability dystrophin-glycoprotein complex. Therefore, determining etiology given...