A5116568578- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
- Machine Learning in Bioinformatics
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Infectious Diseases and Tuberculosis
- Infectious Diseases and Mycology
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Hematological disorders and diagnostics
- Neuroblastoma Research and Treatments
- Turtle Biology and Conservation
- Amphibian and Reptile Biology
- Composting and Vermicomposting Techniques
- Mechanical Failure Analysis and Simulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Essential Oils and Antimicrobial Activity
- Skin Protection and Aging
- Growth Hormone and Insulin-like Growth Factors
- Biochemical and biochemical processes
Universiti Putra Malaysia
2025
Sichuan University
2022-2025
Zhejiang Industry Polytechnic College
2025
West China Second University Hospital of Sichuan University
2025
University of Hong Kong - Shenzhen Hospital
2022-2024
Shenzhen University
2022-2024
Shanghai Jiao Tong University
2022-2024
Nanjing University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Chinese Academy of Medical Sciences Dermatology Hospital
2020-2023
Protein family design emerges as a promising alternative by combining the advantages of de novo protein and mutation-based directed evolution.In this paper, we propose ProfileBFN, Profile Bayesian Flow Networks, for specifically generative modeling families. ProfileBFN extends discrete Network from an MSA profile perspective, which can be trained on single sequences regarding it degenerate profile, thereby achieving efficient avoiding large-scale data construction training. Empirical results...
Transforming growth factor-β-activated kinase 1 binding protein 2 (TAB2) plays a vital role in inflammatory pathways. It has also been considered potential target for the enhancement of antiestrogen effects. Previous evidence indicated that TAB2 gene variants are associated with several diseases, whereas their correlation endometrial cancer (EC) is unclear. This study aims to initially explore association between polymorphisms (rs237028 /AG, rs521845 T/G, and rs652921 T/C) EC. Polymerase...
Abstract Protein language models have demonstrated significant potential in the field of protein engineering. However, current primarily operate at residue scale, which limits their ability to provide information atom level. This limitation prevents us from fully exploiting capabilities for applications involving both proteins and small molecules. In this paper, we propose ESM-AA (ESM All-Atom), a novel approach that enables atom-scale residue-scale unified molecular modeling. achieves by...
Obesity and insulin resistance (IR) are positively associated with chronic kidney disease (CKD). Previous studies have identified triglyceride-glucose index (TyG) as a valuable surrogate of resistance. Recently, new indicators combining TyG simple anthropometric indices emerged, The objective this study was to assess the diagnostic accuracy newly related in detecting CKD explore which were superior associating Chinese population.
Cutaneous tuberculosis with various manifestations can be divided into several clinical types according to the host's immune status and infective route. However, etiological factors of this disease remain unclear. The objective study is investigate pathogens associated occurrence different cutaneous tuberculosis. 58 Mycobacterium strains isolated from over last 20 years were sequenced analyzed for genomic characteristics including lineage distribution, drug-resistance mutations, mutations...
Background Leprosy, caused by Mycobacterium leprae infection, mainly affects skin and peripheral nerves may further lead to disability deformity if not treated timely. The new case detection rate of leprosy in children reflects the active transmission infection. This study aims present epidemiology clinical characteristics cases China from 2011 2020. Methodology/Principal findings All data patients younger than 15 years old were extracted Leprosy Management Information System (LEPMIS)....
The diagnosis of paucibacillary (PB) leprosy often possesses a diagnostic challenge, especially for pure neuritic and lesser skin lesions with the zero bacillary load, requiring sensitive accurate tool. We have included 300 clinically diagnosed new cases (comprising 98 PB cases) analyzed sensitivity specificity by nested PCR folP , gyrA rpoB RLEP 16SrRNA Enzyme-linked Immunospot Assay test (ELISPOT) MMPII, NDO-BSA, LID-1 antigens detecting interferon gamma (IFN-γ) release. overall positivity...
The COVID-19 pandemic has driven public health intervention strategies, including keeping social distance, wearing masks in crowded places, and having good habits, to prevent the transmission of novel coronavirus (SARS-CoV-2). However, it is unknown whether use these strategies influences morbidity other human infectious diseases, such as tuberculosis.In this study, three prediction models were constructed compare variations PTB incidences after January 2020 without or with includes strict...
Objective To analyze the epidemiological features of leprosy in China from 2011 to 2015, and provide scientific evidences for prevention treatment strategies. Methods An analysis a trend were conducted based on national surveillance data 2015. Results The detection rate decreased 0.085 per 100 000 0.049 with an average annual decline being 12.9%. A total 4 775 cases newly detected during 2011—2015, including 106 (2.2%) children, 1 499 (31.4%) females, 518 (10.8%) floating...
There is a high incidence of leprosy among house-contacts compared with the general population. We aimed to establish predictive model using these genetic factors along epidemiological predict risk household contacts (HHCs).Weighted score (wGRS) encompassing genome wide association studies (GWAS) variants and five non-genetic were examined in case-control design associated including 589 cases 647 controls from HHCs. constructed prediction nomogram evaluated its performance by concordance...
This study aimed to determine the incidence of falls and risk factors associated with falling in discharged older adults. A prospective was conducted on adults who had been issued a discharge order Class tertiary hospital Chongqing, China, from May 2019 August 2020. The falling, depression, frailty, daily activities were evaluated at using mandarin version fall self-assessment scale, Patient Health Questionnaire-9 (PHQ-9), FRAIL Barthel Index, respectively. cumulative function estimated...
Background: Glycolysis plays significant roles in tumor progression and immune response. However, the exact role of glycolysis prognosis regulation has not been explored all cancer types. This study first calculated a novel score screened out 12 glycolytic hub genes, comprehensively analyzed molecular expression, clinical implications, features among pan-cancer. Methods: The was derived by single sample gene set enrichment analysis (ssGSEA) algorithm. correlations with parameters were using...
Genome-wide association studies (GWASs) have identified some immune-related single-nucleotide polymorphisms (SNPs) to be associated with leprosy.This study investigated the of 17 SNPs based on previously published GWAS susceptibility leprosy, different polar forms and immune states leprosy in a case-control from southwestern China, including 1344 patients 2732 household contacts (HHCs) (1908 relatives 824 genetically unrelated contact individuals). The differences allele distributions were...
Given their similar appearance and histology, halo nevi (HN) were considered as a type of vitiligo. However, whether HN have stronger immune response than stable vitiligo (VL) remains unclear. In addition, the molecular alterations in compared with normal nevocytic (NN) primary cutaneous melanoma (MM) must be determined. This study aimed to systematically characterize immunological features HN.Skin samples from patients HN, VL, NN, MM obtained informed consent. Each four groups underwent...
Protein language models have demonstrated significant potential in the field of protein engineering. However, current primarily operate at residue scale, which limits their ability to provide information atom level. This limitation prevents us from fully exploiting capabilities for applications involving both proteins and small molecules. In this paper, we propose ms-ESM (multi-scale ESM), a novel approach that enables multi-scale unified molecular modeling. achieves by pre-training on...
Retinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney disease (CKD). However, there is lack of sufficient studies explore the relationship between RBP4 CKD, no reports have described predictive value CKD. This study was designed clarify CKD its potential value.
ABSTRACT Lugs serve as crucial linkages in aircraft structures to connect components and transmit loads motions. Because of their mechanical functions, failure would lead severe consequences. To ensure structural safety, factors that could affect the fatigue performance should be well considered quantified. In this paper, effects inevitable friction clearance between lug load pin are The lives straight oblique lugs predicted by using classical local stress approach a modified theory critical...
Objective To evaluate the value of correlation coefficient between ICP wave amplitude and mean level (RAP) resistance to CSF outflow (Rout) in predicting outcome patients with post-traumatic hydrocephalus (PTH) selected for shunting. Materials Methods As a training set, total 191 PTH treated VP shunting were retrospectively analyzed potential predictive Rout, collected from pre-therapeutic infusion test, desirable recovery (dRL), standing modified rankin scale (mRS) 0–2. Eventually, there 70...
Abstract This report describes an outbreak and treatment of pneumonia enteritis in a snake farm with more than 3000 snakes containing Elaphe carinata (one-year-old) Ptyas mucosus (three-month-old) seedlings Huanggang, Hubei, China. Gentamicin was used once the early stage as treatment, administered orally water or feed by owners, but mortality increased. Lobar confirmed dissection histopathology infected snakes. Four main pathogenic bacteria were isolated identified culture 16S rRNA...