A5115604615- Concrete and Cement Materials Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Biochemical Analysis and Sensing Techniques
- Adrenal Hormones and Disorders
- Extracellular vesicles in disease
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Traumatic Brain Injury Research
- Plant nutrient uptake and metabolism
- Smart Materials for Construction
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Concrete Properties and Behavior
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Barrier Structure and Function Studies
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Intracranial Aneurysms: Treatment and Complications
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Thyroid and Parathyroid Surgery
- Optical Imaging and Spectroscopy Techniques
- Electrolyte and hormonal disorders
Fudan University
2023-2024
Chinese Academy of Sciences
2023-2024
Shenzhen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Sun Yat-sen University
2023-2024
Zhejiang University
2021-2024
Xuzhou Medical College
2024
University of Science and Technology of China
2023-2024
Shanghai East Hospital
2024
Abstract An expansion of AAGGG pentanucleotide repeats in the replication factor C subunit 1 (RFC1) gene is genetic cause cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS), it also links to several other neurodegenerative diseases including Parkinson's disease. However, pathogenic mechanism RFC1 repeat remains enigmatic. Here, we report that form DNA RNA parallel G-quadruplex (G4) structures play a role impairing biological processes. We determine first...
The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal accumulation phosphorylated α-synuclein (αSyn), as well a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike αSyn aggregates, relationship between NM and PD pathogenesis is not understood. In this study, we engineered an E. coli MG1655 strain to produce exosomes containing melanin (E.melanin), investigated its potential neuroprotective effects on DaNs context PD. By...
When it comes to long-acting injections, lyotropic liquid crystals (LLCs) are considered as an effective and powerful drug delivery technology due their low manufacturing injection difficulty, consistent releasing behaviors with burst, well broadly applicable loading capacity. However, monoolein phytantriol, two widely used LLC-forming materials, may give rise tissue cytotoxicity undesired immunological responses, which hinder the wide application of this technology. In study, we opted for...
Abstract Backgroud The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injury induced by ICH, which is crucial for a poor prognosis. Polymorphonuclear leukocyte (PMN) strongly modulate the disruption BBB in central nervous system (CNS). lysophosphatidic acid receptor 1 (LPA1) mediated thrombospondin-1 (TSP1) regulation astrocytes, induce...
Here we presented an electrophysiological dataset collected from layer V of the primary motor cortex (M1) and corresponding behavior normal hemi-parkinson rats over 5 consecutive weeks. The was constituted by raw wideband signal, neuronal spikes, local field potential (LFP) signal. open-field test done recorded to evaluate variation among entire experimental cycle. We conducted technical validation this through sorting spike data form action waveforms analyzing spectral power LFP data, then...
Traumatic brain injury (TBI) causes neuronal cell damage and dysfunction. According to previous studies, daphnetin (Dap) has a protective effect in neurological injury. However, the
ABSTRACT Phosphorus (P) is an essential macronutrient for plant growth and development. Vacuoles play a crucial role in inorganic phosphate (Pi) storage remobilization plants. However, the physiological function of vacuolar efflux transporters Pi remains obscure. Here, we identified three ZmVPE genes ( ZmVPE1 , ZmVPE2a ZmVPE2b ) by combining them with transcriptome quantitative real‐time polymerase chain reaction (PCR) analyses, showing relatively higher expression older leaves than younger...
Extracellular vesicles (EVs) facilitate cell-cell interactions in the tumour microenvironment. However, standard and efficient methods to isolate tissue-derived EVs are lacking, their biological functions remain elusive.
This study aimed to investigate the risk factors and metastatic patterns in papillary thyroid cancer (PTC) patients undergoing lymph node dissection, offering guidance for clinical practice.
To study the non-uniform corrosion of steel rebar induced by chloride ions invasion under marine environment, three-dimensional characteristic distribution aggregates and pores in concrete was numerically extracted reconstructed through X-ray CT technique. Based on 3D in-situ meso-structure model concrete, random characteristics transport investigated numerical simulation. Through a fitting hypothesis test concentration histogram ions, reliable probability density function proposed. And...