A5100325695- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Skin and Cellular Biology Research
- Pharmacological Effects of Natural Compounds
- Probabilistic and Robust Engineering Design
- Numerical methods in inverse problems
- Acute Lymphoblastic Leukemia research
- Genetic and rare skin diseases.
- Cell Adhesion Molecules Research
- Structural Health Monitoring Techniques
- Dermatologic Treatments and Research
- Autoimmune and Inflammatory Disorders Research
- Robotics and Sensor-Based Localization
- Cellular transport and secretion
- Psoriasis: Treatment and Pathogenesis
- Esophageal Cancer Research and Treatment
- Dermatological and Skeletal Disorders
- ECG Monitoring and Analysis
- Wireless Body Area Networks
- Chronic Kidney Disease and Diabetes
- Wnt/β-catenin signaling in development and cancer
- Advanced Numerical Methods in Computational Mathematics
- Robotic Locomotion and Control
China XD Group (China)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2023
Children's Hospital of Zhejiang University
2023
Ruijin Hospital
2022
Shanghai Jiao Tong University
2022
Shanghai Institute of Hematology
2022
Chinese Academy of Medical Sciences Dermatology Hospital
2016-2022
Huashan Hospital
2022
Fudan University
2022
Southern University of Science and Technology
2020
<b><i>Background/Aims:</i></b> In view of the latest findings that matrix metalloproteinase-7 (MMP-7) acted as a vital marker and pathogenic mediator renal fibrosis in murine model, we hypothesized serum MMP-7 level might serve noninvasive prognostic biomarker IgA nephropathy (IgAN) patients. <b><i>Methods:</i></b> We conducted retrospective follow-up study 244 IgAN patients for median 81.9 months. Serum was detected at time diagnosis,...
Recurrent MEF2D fusions with poor prognosis have been identified in B-cell precursor ALL (BCP-ALL). The molecular mechanisms underlying the pathogenic function of are poorly understood. Here, we show that MEF2D-HNRNPUL1 (MH) knock-in mice developed a progressive disease from impaired development at pre-pro-B stage to pre-leukemia over 10 12 months. When cooperating NRASG12D, MH drove an outbreak BCP-ALL, more aggressive phenotype than NRASG12D-induced leukemia. RNA-sequencing key networks...
Reports on antimicrobial resistance (AMR) of Mycobacterium leprae, relationship with bacteriological index (BI), and transmission in China are limited. We investigated the emergence AMR mutations, between BI complete, moderate lack decline cases, molecular epidemiological features cases by enrolling 290 leprosy from four endemic provinces. Seven (2.41%), one (0.34%), five (1.72%), (0.34%) strains had single mutations folP1, rpoC, gyrA, gyrB, 23S rRNA, respectively. Double folP1 rpoB gyrA...
The common human coronaviruses (HCoVs) HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 which are members of the coronavirus family long co-existed with humans widely distributed globally. Common HCoVs usually cause mild, self-limited upper respiratory tract infections (URTI), also associated lower (LRTI), especially in children. However, there little multicentre studies have been conducted children several different areas China, epidemic potential remains unclear. Understanding is valuable...
Psoriasis (Ps) and leprosy are chronic inflammatory skin disorders, characterised by enhanced innate adaptive immunity. Ps rarely coexist. The molecular immune mechanism of the coexistence is unclear.RNA-sequencing (RNA-seq) was performed on 20 patients with Ps, 5 adults lepromatous (L-lep), tuberculoid (T-lep) to analyse differentially expressed genes (DEGs) between them. Moreover, biological explored Kyoto Encyclopedia Genes Genomes (KEGG) analysis, Gene Ontology (GO) Set Enrichment...
In this work, we investigate the regularized solutions and their finite element to inverse source problems governed by partial differential equations, establish stochastic convergence optimal rates of these under pointwise measurement data with random noise. The regularization error estimates are derived explicit dependence on noise level, parameter, mesh size, time step which can guide practical choices among key parameters in real applications. also suggest an iterative algorithm for...
Abstract Mycobacterium gordonae is often regarded as a weak pathogen that only occasionally causes overt disease. We report case of M. infection in the facial skin, nasal mucosa, and paranasal sinus an immunocompetent patient review previous cases. The T-SPOT.TB test might be useful diagnosing such
Purpose:The presence of Langhans giant cell (LGC) is a hallmark mycobacterium-induced granuloma.The molecular characteristics and functions LGC remain unclear to date.The study aimed systematically characterize the reveal potential functions.Methods: Human LGCs were purified through laser capture microdissection (LCM) in vitro.RNA sequencing in-depth transcriptome analysis performed for macrophages same system.Skin samples from mycobacterial infection patients used confirm some...
Abstract Bart's syndrome (BS), characterized by aplasia cutis congenita (ACC, also called congenital localized absence of skin) and epidermolysis bullosa (EB), is diagnosed clinically based on the disorder's unique signs symptoms. We report case a family, three members which presented with ACC at birth one had blisters mucous membranes. The patient was treated conservatively topical antibacterial ointment wet gauze dressing. Periodic follow up showed complete healing minimal scarring....
This paper studies dynamic obstacle avoidance strategies of quadruped robots in an unknown and dynamically changing environment. Different from classical navigation problems with static environment, number moving obstacles dynamics are present the scenario considered this paper. rapidly environment prevents us directly applying existing approaches for robots. To address additional challenges introduced by obstacles, improved window approach (DWA) is proposed which both evaluation function...
A systems approach was used to explore the genome and transcriptome of Mycobacterium shigaense, a new opportunistic pathogen isolated from patient with skin infection, host response assessed using macrophage infection model. The M. shigaense comprises 5,207,883 bp, 67.2% G+C content 5098 predicted coding genes. Evolutionarily, bacterium belongs cluster in phylogenetic tree along three target pathogenic strains, namely, avium, triplex simiae. Potential virulence genes are indeed expressed by...
Abstract: Lucio’s phenomenon (LP) is a special reactional state associated with diffuse multibacillary leprosy; both exhibit limitative global distribution mainly in Mexico and Central America. We report case of 28-year-old female leprosy patient the People’s Republic China, together LP positive anticardiolipin antibody, characterized by vascular thrombosis invasion blood vessel walls bacilli, causing extensive skin ulcers followed large number atrophic scars. Keywords: Leprosy, phenomenon, antibody
In this paper we propose a finite element method for solving elliptic equations with the observational Dirichlet boundary data which may subject to random noises. The is based on weak formulation of Lagrangian multiplier. We show convergence error in expectation and, when noise sub-Gaussian, Orlicz 2- norm implies probability that estimates are violated decays exponentially. Numerical examples included.
Esophageal squamous cell carcinoma (ESCC) has limited effective treatment strategies. DNA damage response (DDR) genes are of therapeutic interest in multiple cancer types. This study aimed to depict the landscape DDR mutations ESCC and evaluate association between known immunotherapy biomarkers. We recruited 250 Chinese patients with performed next-generation sequencing. A total 107 underwent a PD-L1 examination. Among patients, 73 (29.2%) harbored at least one gene mutation were defined as...
In this work, we investigate the regularized solutions and their finite element to inverse source problems governed by partial differential equations, establish stochastic convergence optimal rates of these solutions, under pointwise measurement data with random noise. Unlike most existing regularization theories, error estimates are derived without any conditions, while show explicit dependence on noise level, parameter, mesh size, time step which can guide practical choices among key...
Common laboratory assays for the diagnosis of tuberculosis include acid-fast smear, tissue culture, histopathological study, PCR, and so on. T-SPOT.TB assay, a new auxiliary method diagnosis, belongs to interferon-gamma release assays, has been more widely applied in clinical practice. This review summarizes principles characteristics as well its application values diagnosing cutaneous tuberculosis, exploring pathogenesis tuberculous infection-related skin diseases, evaluating risk latent...
A 7-year-old girl presented with a plaque on the left side of face for 4 years. Skin examination revealed well-marginated circular firm measuring 6 cm × 5 in size purulent crusts surface, which was nontender to palpation. Histopathologic study showed ulceration and necrosis some areas epidermis, diffuse dermal infiltration lymphocytes, histiocytes epithelioid cells presence many neutrophilic granulocytes regions. Both periodic acid-Schiff (PAS) staining acid-fast were negative. After 25 days...
Human pathogenic mycobacteria, including Mycobacterium tuberculosis, leprae and non-tuberculosis greatly threaten human health. infections are closely related to the host genetic background. Studies have indicated that genes play important roles in infections. Recently, a variety of been identified be associated with susceptibility by genome-wide association studies, large-scale population-based case/control studies on candidate genes, family-based linkage investigations rare individuals...