A5013441823- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Ion Channels and Receptors
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Wnt/β-catenin signaling in development and cancer
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Silk-based biomaterials and applications
- Bladder and Urothelial Cancer Treatments
- Genetic and rare skin diseases.
- Skin Protection and Aging
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Urinary and Genital Oncology Studies
- COVID-19 and healthcare impacts
- Dermatological and Skeletal Disorders
- Contact Dermatitis and Allergies
- High Altitude and Hypoxia
- Metabolism and Genetic Disorders
- Exercise and Physiological Responses
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Urinary Tract Infections Management
- Aldose Reductase and Taurine
Chinese Academy of Medical Sciences & Peking Union Medical College
1995-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2022-2024
Institute of Hematology & Blood Diseases Hospital
2022-2023
Peking University
2019-2022
National Clinical Research Center for Digestive Diseases
2021-2022
SKiN Health
2022
Peking Union Medical College Hospital
1995-2022
Institute of Dermatology
2022
Peking University First Hospital
2019-2022
Stony Brook University
2019-2021
In this report, we made use of sorbitol dehydrogenase (SDH)-deficient mutant mice (C57BL/LiA) to test whether there is a close correlation between the level polyol accumulation and degree reduction in motor nerve conduction velocity (MNCV) associated with diabetes. The C57BL/LiA mouse has SDH deficiency due G-to-A mutation at +1 position intron 8, thus producing only aberrant transcripts. These should have higher levels peripheral because inability further metabolize fructose. Here, confirm...
Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying cell-fate reprogramming remain unclear. Here, a transcriptome-based screen of biologically active compounds uncovered that CDK8 inhibition was essential enable from fibroblasts XEN-like cells, then CiPSCs. RNA-sequencing analysis showed downregulated proinflammatory...
Nagashima-type palmoplantar keratoderma (NPPK) is the most prevalent hereditary (PPK) in China, but there a paucity of epidemiological data on Chinese population. To explore clinical and genetic characteristics, evaluate demographic distribution, estimate burden disease NPPK. A total 234 patients with NPPK were enrolled from two medical centers an online PPK support group. Next-generation sequencing Sanger performed to screen out confirm pathogenic mutations SERPINB7. Clinical features...
High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research. However, simultaneous detection activated core factors responsible fate determination accurate assessment directional transition are difficult using conventional methods that focus on changes in only few biomarkers. The PHDs-seq (Probe Hybridization based Drug by sequencing) platform was developed to evaluate compound function their transcriptional effects wide...
Laryngeal closure following hypoxic gasps has been documented, but its efficacy in improving autoresuscitation capacity is unknown. We studied SWR/J mice who normally cannot autoresuscitate and the C57/BLJ strain can. evaluated effects of elevated end-inspiratory lung volume immediately a gasp. compared upper airway-intact with tracheostomized which vocal cords are bypassed. used techniques repeated trials to test capability. Both could maintain after gasp (breath holding). Such breath...
Objective: To describe the gene mutation profile of newly diagnosed pediatric B-acute lymphoblastic leukemia (B-ALL) and analyze its effect on minimal residual disease (MRD). Methods: A total 506 B-ALL children treated in Institute Hematology & Blood Diseases Hospital, Chinese Academy Medical Sciences from September 2018 to July 2021 were enrolled this retrospective cohort study. The divided into MRD ≥1.00% group <1.00% according results 19th day since chemotherapy, ≥0.01% <0.01% 46th day....
Abstract Keratosis follicularis spinulosa decalvans (KFSD) is a rare X‐linked hereditary disorder characterized by the triad of follicular hyperkeratosis‐photophobia‐alopecia. The clinical heterogeneity makes diagnosis difficult. To investigate clinicopathologic and trichoscopic features KFSD to further clarify essential requisites for diagnosis, we conducted retrospective study patients with KFSD. information, histologic features, findings were evaluated. Eight from seven separate families....
To investigate the clinical features of coronavirus disease 2019 (COVID-19) in patients with aplastic anemia (AA) undergoing immunosuppressive therapy (IST) .