A5000436172- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Chromatin Remodeling and Cancer
- Data Mining Algorithms and Applications
- Recommender Systems and Techniques
- Semantic Web and Ontologies
- Peptidase Inhibition and Analysis
- Biomarkers in Disease Mechanisms
- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Menopause: Health Impacts and Treatments
- Genomics and Chromatin Dynamics
- Hemoglobinopathies and Related Disorders
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Sexual function and dysfunction studies
- Cancer Mechanisms and Therapy
Nanjing University of Chinese Medicine
2013-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2013-2024
Nanjing University
2017-2022
Nanjing Drum Tower Hospital
2018-2021
Stamatopoulos and Associates (Greece)
2018
China Academy of Chinese Medical Sciences
2013
Jiangsu University
2006
First People's Hospital of Kunshan
2006
Aberrant changes in epigenetic mechanisms such as histone modifications play an important role cancer progression. PRMT1 which triggers asymmetric dimethylation of H4 on arginine 3 (H4R3me2a) is upregulated human colorectal (CRC) and essential for cell proliferation. However, how this dysregulated modification might contribute to malignant transitions CRC remains poorly understood.In study, we integrated biochemical assays including protein interaction studies chromatin immunoprecipitation...
The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying c-Myc-mediated repression in context of cancer remain less clear. This study aimed to clarify role PRMT5 transcriptional target genes gastric cancer. Methods: Immunohistochemistry was used evaluate expression PRMT5, and patients. interaction assessed by immunofluorescence, co-immunoprecipitation GST pull-down assays. Bioinformatics...
N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities lung cancer cells vitro vivo. Depletion suppresses epithelial-to-mesenchymal transition (EMT) by directly repressing expression transcription factor Slug, a key regulator EMT. We found Nt-acetylation antagonizes serine 1 phosphorylation (H4S1ph), downregulation facilitates CK2α binding...
Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, molecular mechanisms underlying EC progression are still largely unknown, and chemotherapeutic options for patients currently very limited. In this study, we found that histone methyltransferase EZH2 DNA DNMT3B were upregulated in samples from patients, promoted cell proliferation as evidenced by assays of viability, cycle, colony formation. Mechanistically, epigenetically repressing TCF3, a direct...
This study aimed to identify differentially expressed genes (DEGs) and molecular pathways in eutopic endometrial stromal cells (EuESCs) from adenomyosis (AM) patients provide a new insight into the disease mechanisms. The gene expression profiles adenomyotic EuESCs (A-EuESCs) normal ESCs (N-ESCs) were analyzed by RNA-sequencing (RNA-Seq) validated quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) enrichment...
To evaluate the effect of Wenshen Xiaozhng Tang (WXT) on ectopic endometrial growth and angiogenesis in implants a rat model.Sprague-Dawley rats with endometriotic were randomly treated low-dose WXT, high-dose or vehicle (negative control) for 28 days. Cell proliferation vascular density lesions assessed by immunohistochemistry. The levels VEGF peritoneal fluid determined ELISA. mRNA expression HIF-1α Flk-1 was evaluated real-time PCR.WXT treatment significantly decreased lesion size...
Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer. However, the functions methyltransferases that trigger H4K20 methylation in cancers, including suppressor variegation 4-20 homolog 1 (Suv4-20h1), remain elusive. In present study, it was demonstrated knockdown methyltransferase Suv4-20h1 resulted growth inhibition chronic myeloid leukemia K562 cells. Disruption expression induced G1 arrest cell cycle and increased levels cyclin dependent kinase inhibitor 1A...
Retrieval-Augmented Generation (RAG) significantly improved the ability of Large Language Models (LLMs) to solve knowledge-intensive tasks. While existing research seeks enhance RAG performance by retrieving higher-quality documents or designing RAG-specific LLMs, internal mechanisms within LLMs that contribute effectiveness systems remain underexplored. In this paper, we aim investigate these popular Mixture-of-Expert (MoE)-based and demonstrate how improve examining expert activations in...
Female sexual arousal disorder (FSAD) is a common issue causing physical and psychological pain, but it has no standard diagnostic criteria or treatment. So its pathogenesis desiderates to be explored. To investigate the specific function of miR-122-5p in FSAD. 18 subjects were grouped into FSAD normal control groups according Chinese version Sexual Function Index, expression levels vasoactive intestinal peptide receptor 1 (VIPR1) protein their tissue verified through real-time quantitative...