A5090452535- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Systemic Sclerosis and Related Diseases
- Cancer-related gene regulation
- Parathyroid Disorders and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Advancements in Transdermal Drug Delivery
- Systemic Lupus Erythematosus Research
- Advanced Drug Delivery Systems
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Dermatologic Treatments and Research
- Hormonal and reproductive studies
- Peptidase Inhibition and Analysis
- Salivary Gland Disorders and Functions
- Toxoplasma gondii Research Studies
Nanjing Drum Tower Hospital
2018-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing University of Chinese Medicine
2023
Southeast University
2023
Nanjing University
2015-2020
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Northwest Minzu University
2014
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2014
N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities lung cancer cells vitro vivo. Depletion suppresses epithelial-to-mesenchymal transition (EMT) by directly repressing expression transcription factor Slug, a key regulator EMT. We found Nt-acetylation antagonizes serine 1 phosphorylation (H4S1ph), downregulation facilitates CK2α binding...
Aurora kinase B (AURKB) triggers the phosphorylation of serine 10 on histone H3 (H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis in mammals.However, how exactly AURKB controls cell cycle contributes to tumorigenesis as an oncoprotein under pathological conditions remains largely unknown.Here, we report that promotes gastric cancer proliferation vitro vivo.Silencing expression inhibits arrests G2/M phase.We demonstrate cyclin D1 (CCND1) a direct...
Microparticles (MPs)-based delivery systems have a demonstrated value in gastrointestinal administration. Research this area is focusing on the development of multifunctional MPs to improve effects. Herein, learning from natural morphology peony pollens, novel multilobe for target surface adhesion and durable drug release are pesented. Ascribing flexibility microfluidic technology combination selective hydrogel degradation methods, with series structures can be obtained using alginate...
Abstract Mesenchymal stem cell (MSC) therapy is a promising candidate for inflammatory bowel disease (IBD) treatment, while overcoming the limitations of naive seeding cells function and realizing efficient intestinal targeting remains challenge. Here, bioadhesive microparticle carrying interleukin‐27 (IL‐27) MSC‐derived extracellular vesicles (MSC IL‐27 EVs) developed to treat IBD. The MSC EVs prepared through lentivirus‐mediated gene transfection technology show ideal anti‐inflammatory...
Colorectal cancer pathogenesis remains incompletely understood. Here, we report that the heterochromatin protein HP1γ is upregulated commonly in human colorectal cancer, where it promotes cell proliferation vitro and vivo. Gene-expression promoter-binding experiments demonstrated directly regulated CDKN1A (p21(Waf1/Cip1)) a manner associated with methylation of histone H3K9 on its promoter. We identified miR-30a as tumor-suppressive microRNA targets vivo to specifically suppress growth mouse...
Intelligent responsive microcarriers have emerged as a promising class of biomaterials for therapeutic delivery and tissue regeneration, since they can respond to external stimuli release the loaded drugs in an active manner. Among various available stimuli, near-infrared (NIR) light is particularly attractive because it penetrate biotic tissues with sufficient intensity minimal damage. In this work, kind photoresponsive (PDMs) developed using microfluidics. The consist NIR-absorbing...
Abstract Microneedle (MN) patches are promising stratagems for transdermal drug delivery owing to its minimal invasiveness and portability. Particularly, separable MN attract more attention durable long‐term delivery. Here, a new strategy designing controllably by integrating photothermal responsive phase‐changing microspheres (MPs) into conical hydrogel MNs, is presented. Such MPs consist of near‐infrared (NIR)‐responsive black‐phosphorus (BP) gelatin (GT), fabricated using simple capillary...
Mesenchymal stem cells (MSCs), which exert regulatory effects on various immune cells, have been a promising therapy for inflammatory bowel disease treatment. However, their therapeutic are limited by lack of nutritional supply, system attack, and low accumulation the target site. Here, inspired natural incubation mechanism roe, we present immune-isolating, wet-adhesive, nutrient-rich microcapsules MSCs encapsulation. The adhesive shells were fabricated ionic cross-linking alginate visible...
Mesenchymal stem cells (MSCs) therapy is a promising treatment for Systemic lupus erythematosus (SLE) patients. However, this method encumbered by suboptimal phenotype of MSCs used in clinical settings, and short vivo persistence time. Herein, inspired the natural microstructure sand tower worm nest, we proposed novel adhesive porous particles with human encapsulation via microfluidic electrospray technology SLE treatment. The microparticles were formed immediate gelation reaction between...
Abstract Oral drug administration has an important role in medical treatment. Attempts to develop microcarriers with desired features for extended duration and improved absorption is highly sought. Herein, inspired by the physical phenomenon of Cheerios effect, a novel microfluidic electrospray microbubble carrier presented that can suspend actively adhere stomach durable oral delivery. Compared conventional fabrication methods, present strategy shows stability controllability product....
As a novel cellular therapy, the anti-inflammatory and immunomodulatory virtues of mesenchymal stem cells (MSCs) make them promising candidates for systemic sclerosis (SSc) treatment. However, clinical efficacy this stratagem is limited because short persistence time, poor survival, engraftment MSCs after injection in vivo. Herein, we develop MSCs-laden injectable self-healing hydrogel SSc The prepared using N, O-carboxymethyl chitosan (CS-CM) 4-armed benzaldehyde-terminated polyethylene...
Traditional Chinese medicine, such as Tripterygium wilfordii and Paeonia lactiflora , has potential values in treating systemic sclerosis (SSc) other autoimmune diseases, while their toxic side effect elimination precise tropical drug delivery are still challenges. Here, we present multiple traditional medicine integrated photoresponsive black phosphorus (BP) microneedles (MNs) with the desired features for SSc treatment. By employing a template-assisted layer-by-layer curing method, MNs...
The clinical significance of CXCR4 expression in colorectal cancer remains unclear. aim this study was to investigate the and regulatory effects association between protein prognosis. mRNA levels were determined using reverse-transcriptase polymerase chain reaction immunohistochemistry staining, respectively, relationship level clinicopathological parameters analyzed 720 cases cancer. elevated tissues compared pericancerous (P = 0.001). Of enrolled cases, 208 (28.89%) expressed CXCR4. In...
// Yupeng Wu 1, 2, * , Ming Liu Zhuchen Li 1 Xiao-Bin 3 Ying Wang Yadong Min Nie Feifei Huang Junyi Ju Chi Ma Renxiang Tan Ke Zen Chen-Yu Zhang Keqin Fu 2 Yu-Gen Chen Ming-Rong 4 Quan Zhao The State Key Laboratory of Pharmaceutical Biotechnology, School Life Sciences, Nanjing University, Nanjing, 210046, China Anhui Research Institute for Family Planning, Center Population and Birth Control, Hefei, 230031, Affiliated Hospital University Chinese Medicine, 210029, Molecular Oncology, Cancer...
Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer. However, the functions methyltransferases that trigger H4K20 methylation in cancers, including suppressor variegation 4-20 homolog 1 (Suv4-20h1), remain elusive. In present study, it was demonstrated knockdown methyltransferase Suv4-20h1 resulted growth inhibition chronic myeloid leukemia K562 cells. Disruption expression induced G1 arrest cell cycle and increased levels cyclin dependent kinase inhibitor 1A...