A5100712373- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- High Temperature Alloys and Creep
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Additive Manufacturing Materials and Processes
- Chinese history and philosophy
- High-Temperature Coating Behaviors
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal Regulation and Hypertension
- Hemoglobinopathies and Related Disorders
- Blood Pressure and Hypertension Studies
- Translation Studies and Practices
- Water Treatment and Disinfection
- RNA Research and Splicing
- Plant Stress Responses and Tolerance
- Metallurgical Processes and Thermodynamics
- Neuroscience and Neural Engineering
- Prenatal Screening and Diagnostics
- Pharmaceutical Economics and Policy
- Methemoglobinemia and Tumor Lysis Syndrome
- TGF-β signaling in diseases
- Plant responses to elevated CO2
- Genetic Neurodegenerative Diseases
Fudan University
2015-2025
Sichuan Agricultural University
2012-2025
Huashan Hospital
2015-2025
Weatherford College
2025
Eye & ENT Hospital of Fudan University
2024
State Key Laboratory of Medical Neurobiology
2010-2024
Lanzhou Jiaotong University
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Zhongshan Hospital
2007-2023
Tianjin Hospital
2022
Abstract The physiological interactions between the peripheral and central auditory systems are crucial for information transmission perception, while reliable models neural circuits currently lacking. To address this issue, mouse human pathways generated by utilizing a carbon nanotube nanofiber system. super‐aligned pattern of scaffold renders axons bipolar multipolar neurons extending in parallel direction. In addition, electrical conductivity maintains electrophysiological activity...
The present study used comparative proteomic analysis of cerebrospinal fluid (CSF) in amyotrophic lateral sclerosis (ALS) patients order to identify proteins that may act as diagnostic biomarkers and indicators the pathogenesis ALS. This was performed using isobaric tags for relative absolute quantitation (iTRAQ) technology, coupled with 2-dimensional liquid chromatography/mass spectrometry. Database Annotation, Visualization Integrated Discovery software utilized bioinformatic data....
Abstract Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease, with most sporadic cases lacking clear genetic causes. Abnormal pre-mRNA splicing fundamental mechanism in neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) loss-of-function (LOF) causes widespread RNA mis-splicing events ALS. Additionally, mutations are major contributors to neurological disorders. However, the role of intronic variants driving ALS remains poorly understood. To address...
Sodium nitrite, often mistaken for common table salt or sugar due to its similar appearance, has resulted in poisoning incidents. This report details a cluster of sodium nitrite stemming from dinner gathering on maintenance ship. The epidemiological investigation aims uncover the incident’s cause, provide clinical insights, and offer preventive recommendations events future. Individual interviews were conducted with all suspected cases, capturing basic information, symptoms onset times,...
As one of the most salt-sensitive crops, strawberry production is severely limited by salt stress. γ--aminobutyric acid (GABA) has been reported to play an important role in immune response plants. In this study, physiological and transcriptomic changes seedlings treated with GABA under stress were investigated explore effect on tolerance. The results showed that exogenous maintained high osmolyte levels, increased antioxidant capacity, decreased ROS levels leaves stress; MDA was reduced...
AIM:To identify the proportion, causes and nature of drug-induced liver injury (DILI) in patients with notably elevated alanine aminotransferase (ALT). METHODS:All inpatients ALT levels above 10 times upper limit normal range (ULN) were retrospectively identified from a computerized clinical laboratory database at our hospital covering 12-mo period.Relevant information was obtained medical records.Alternative elevations examined for each patient, including biliary abnormality, viral...
Abstract Background TARDBP mutations have been reported in patients with amyotrophic lateral sclerosis (ALS) different populations except Chinese. The present aim is to investigate the association between and Chinese ALS. Methods 71 SALS 5 FALS families non- SOD1 were screened for via direct sequencing. Results A novel heterozygous variation, Ser292Asn (875G>A), was identified proband 4 asymptomatic relatives including children of dead patient from a family. Thus patient, proband's...
Abstract Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with uncertain genetic predisposition in most sporadic cases. The spatial architecture of cell types and gene expression are the basis cell–cell interactions, biological function pathology, but not well investigated human cortex, key ALS-relevant brain region. Recent studies indicated single nucleus transcriptomic features vulnerability ALS cortex. However, regional ALS-associated genes link between region-specific...
Superoxide dismutases (SODs), as the first line of defense against reactive oxygen species (ROS), play an essential role in protecting plants from adverse elicitors during plant growth and development. However, little is known about SOD gene family their response to salinity stress fruit development cultivated strawberries (Fragaria × ananassa). In this study, 32 genes consisting 16 Cu/ZnSODs, 11 FeSODs, 5 MnSOD were identified, which presented three well-resolved clades phylogenetic tree....
We discuss when a sequence of positive integers can be the multidegree some tame automorphism in dimension three, and we also relate these investigations to problem whether there exists admitting reduction type II or III.
The phase precipitation behavior of a new type nickel based superalloy cast with low cobalt was studied by using JMatPro and differential scanning calorimetry, the microstructure composition ingot were compared actual ingot. results show that structure alloy mainly includes γ(mateix),γ´,σ,μ,carbides(MC,M6C,M23C6) γ+γ′ eutectic structure(volume fraction about 13.9%).Positive segregation occurs in Ta Hf during solidification. initial melting point, final point γ-phase remelting temperature are...