A5100699264- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Ovarian function and disorders
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Medicinal Plant Pharmacodynamics Research
- Birth, Development, and Health
- Hernia repair and management
- Ferroptosis and cancer prognosis
- Hormonal and reproductive studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Injury Epidemiology and Prevention
- Maternal and Neonatal Healthcare
- Anorectal Disease Treatments and Outcomes
- Child and Adolescent Health
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
- FOXO transcription factor regulation
- Cancer, Lipids, and Metabolism
- Pregnancy-related medical research
- Urinary Bladder and Prostate Research
Nanjing Maternity and Child Health Care Hospital
2016-2024
Nanjing Medical University
2016-2024
Women's Hospital
2024
Southeast University
2013
Abstract Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation lncRNAs is involved in progression many types cancer, including epithelial ovarian cancer (EOC). To explore potential roles EOC, we performed lncRNA mRNA microarray profiling malignant benign cyst healthy control tissues. In this study, 663 transcripts were found to be differentially expressed EOC compared with normal We also selected 18 altered confirm validity analysis using...
Ovarian cancer (OC) is the most fatal gynaecological malignancy and has a poor prognosis. Glycosylation, biosynthetic process that depends on specific glycosyltransferases (GTs), recently attracted increasing importance due to vital role it plays in cancer. In this study, we aimed determine whether OC patients could be stratified by glycosyltransferase gene profiles better predict prognosis efficiency of immune checkpoint blockade therapies (ICBs).We retrieved transcriptome data across 420...
Childhood obesity is worsening at dramatic rates and has become a public health crisis. This study investigated these trends in childhood examined parental factors that may contribute to overweight obesity. Body mass index (BMI) was calculated from height weight measurements taken annually 2004 2007 subsample of 136 children (2-4 years old), the Jintan Child Health Project China. Parental were assessed through self-administered questionnaire. Prevalence rose 6.6% 2.2% 15.4% ( p < .05)....
The objective of the study was to explore clinical significance steroid hormones in diagnosis PCOS and PCOS-related insulin resistance through liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) chemiluminescent immunoassay (CLIA).The included 114 patients with 100 controls. Steroid hormone levels serum were measured using LC-MS/MS CLIA. Bland-Altman method used check consistency between two methods. diagnostic value for female hyperandrogenemia evaluated.Women younger than...
Polycystic ovarian syndrome (PCOS) is a common endocrinopathy associated with increased risk of metabolic disorders. Prevalence adiposity and obesity greater in women suffering from PCOS. Moreover, adipose tissue dysfunction has been demonstrated PCOS patients, particularly abdominal tissue. This likely aggravates the reproductive abnormalities. We used liquid chromatography‐mass spectrometry to compare peptides secreted non‐PCOS detected 298 upregulated 31 downregulated (absolute fold...
We aimed to determine the prevalence of urinary incontinence (UI) during peri- and postpartum period in women from Nanjing, China, estimate its risk factors.From January December 2018, a total 6500 were enrolled asked complete questionnaires. Of these, 6370 (98%) returned questionnaires with valid responses. Additional data collected, including age, height, weight, gestation time parity, neonatal weight. The International Consultation on Incontinence Questionnaire-Urinary Short Form was...
Recent studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in many types of human malignant cancers. However, the function lncRNAs benign tumors remains poorly understood. In present study, to explored potential epithelial ovarian cysts (BEOCs) which commonly occur young women and possess potential, we described expression profile between BEOC normal tissues using lncRNA microarray techniques. The results showed 1,325 transcripts (1,014 upregulated 311 downregulated) were...
Abstract Background Epithelial-mesenchymal transition (EMT) plays critical roles in cancer progression and metastasis. Thus, the exploration of molecular mechanism regulating EMT would provide potential opportunities for therapy metastatic ovarian (OC). Herein, we investigated putative role KMT2A modulating metastasis OC. Methods The expression OC was detected by western blot immunohistochemistry its relationship with clinicopathological factors analyzed. effect on biological behavior cells...